Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicholas D LeBlond"'
Autor:
Corina M Stewart, Alexandra Phan, Yuxia Bo, Nicholas D LeBlond, Tyler K T Smith, Geneviève Laroche, Patrick M Giguère, Morgan D Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pat
Externí odkaz:
https://doaj.org/article/c6998978276948f2b5a5a62d2e027cdc
Autor:
Conor O’Dwyer, Rebecca Yaworski, Sakie Katsumura, Peyman Ghorbani, Kaelan Gobeil Odai, Julia R.C. Nunes, Nicholas D. LeBlond, Sabrin Sanjana, Tyler T.K. Smith, Shauna Han, Kaitlyn D. Margison, Tommy Alain, Masahiro Morita, Morgan D. Fullerton
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 876-889 (2020)
Choline is an essential nutrient and a critical component of the membrane phospholipid phosphatidylcholine (PC), the neurotransmitter acetylcholine, while also contributing to the methylation pathway. In the liver specifically, PC is the major membra
Externí odkaz:
https://doaj.org/article/6f21bd4cf0e644f38c1cf1dba71d17bc
Autor:
Truc T. Losier, Mercy Akuma, Olivia C. McKee-Muir, Nicholas D. LeBlond, Yujin Suk, Reham M. Alsaadi, Zhihao Guo, Ryan Reshke, Subash Sad, François-Xavier Campbell-Valois, Derrick J. Gibbings, Morgan D. Fullerton, Ryan C. Russell
Publikováno v:
Cell Reports, Vol 26, Iss 8, Pp 2150-2165.e5 (2019)
Summary: The autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria. However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear. H
Externí odkaz:
https://doaj.org/article/216c61e2ffd6423494b6506f679e28bd
Autor:
Tyler K. T. Smith, Zaina Kahiel, Nicholas D. LeBlond, Peyman Ghorbani, Eliya Farah, Refel Al-Awosi, Marceline Cote, Suresh Gadde, Morgan D. Fullerton
Publikováno v:
Molecules, Vol 24, Iss 20, p 3751 (2019)
Activation of the transcription factor liver X receptor (LXR) has beneficial effects on macrophage lipid metabolism and inflammation, making it a potential candidate for therapeutic targeting in cardiometabolic disease. While small molecule delivery
Externí odkaz:
https://doaj.org/article/cb304655a93c425f8213673b1820152c
Autor:
Corina M. Stewart, Stephanie S. Dorion, Marie A. F. Ottenbrite, Nicholas D. LeBlond, Tyler K. T. Smith, Shirley Qiu, Morgan D. Fullerton, Darwyn Kobasa, Marceline Côté
Publikováno v:
Viruses, Vol 11, Iss 3, p 206 (2019)
Filoviruses, such as Ebola virus (EBOV) and Marburg virus, are causative agents of unpredictable outbreaks of severe hemorrhagic fevers in humans and non-human primates. For infection, filoviral particles need to be internalized and delivered to intr
Externí odkaz:
https://doaj.org/article/9f7aa63f144a4b4e8dd6064ba8b9653c
Autor:
Masahiro Morita, Morgan D. Fullerton, Kaelan Gobeil Odai, Nicholas D. LeBlond, Rebecca A. Yaworski, Sabrin Sanjana, Shauna Han, Conor O’Dwyer, Kaitlyn D. Margison, Tyler T.K. Smith, Tommy Alain, Peyman Ghorbani, Julia R. C. Nunes, Sakie Katsumura
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 876-889 (2020)
Hepatology Communications
Hepatology Communications
Choline is an essential nutrient and a critical component of the membrane phospholipid phosphatidylcholine (PC), the neurotransmitter acetylcholine, while also contributing to the methylation pathway. In the liver specifically, PC is the major membra
Autor:
Yuan Y. Zhao, René L. Jacobs, Danny Galleguillos, Nicholas McCloskey, Susanne Lingrell, Jelske N. van der Veen, Jonathan M. Curtis, Morgan D. Fullerton, Simonetta Sipione, Nicholas D. LeBlond, Dennis E. Vance
Publikováno v:
The FASEB Journal. 33:5045-5057
Phosphatidylethanolamine N-methyltransferase (PEMT) is an important enzyme in hepatic phosphatidylcholine (PC) biosynthesis. Pemt-/- mice fed a high-fat diet are protected from obesity and whole-body insulin resistance. However, Pemt-/- mice develop
Autor:
Erin E. Mulvihill, Conor O’Dwyer, Nicholas D. LeBlond, Marc Foretz, Natasha Trzaskalski, Julia R. C. Nunes, Peyman Ghorbani, Nia Ambursley, Tyler K. T. Smith, Morgan D. Fullerton, Benoit Viollet
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, pp.jlr.RA120001040. ⟨10.1194/jlr.RA120001040⟩
Journal of Lipid Research, Vol 61, Iss 12, Pp 1697-1706 (2020)
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, pp.jlr.RA120001040. ⟨10.1194/jlr.RA120001040⟩
Journal of Lipid Research, Vol 61, Iss 12, Pp 1697-1706 (2020)
International audience; The dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b419446bdc7b8412b748e73cae73cfb1
https://hal.archives-ouvertes.fr/hal-03025479/document
https://hal.archives-ouvertes.fr/hal-03025479/document
Autor:
Tyler K. T. Smith, Conor O’Dwyer, Natasha Trzaskalski, Peyman Ghorbani, Viollet Benoit, Marc Foretz, Erin E. Mulvihill, Morgan D. Fullerton, Julia R. C. Nunes, Nicholas D. LeBlond, Nia Ambursley
ObjectiveThe dysregulation of myeloid-derived cell metabolism can drive atherosclerosis. AMP-activated protein kinase (AMPK) controls various aspects of macrophage dynamics and lipid homeostasis, which are important during atherogenesis.Approach and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49146a6616b40f93ca3ff6b3c655138e
https://doi.org/10.1101/2020.07.15.204487
https://doi.org/10.1101/2020.07.15.204487
Autor:
Tyler K. T. Smith, Martin Pelchat, Darwyn Kobasa, Patrick M. Giguère, Geneviève Laroche, Morgan D. Fullerton, Alexandra Phan, Yuxia Bo, Nicholas D. LeBlond, Corina M Stewart, Marceline Côté
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
PLoS Pathogens, Vol 17, Iss 1, p e1009275 (2021)
Filoviruses, such as the Ebola virus (EBOV) and Marburg virus (MARV), are causative agents of sporadic outbreaks of hemorrhagic fevers in humans. To infect cells, filoviruses are internalized via macropinocytosis and traffic through the endosomal pat