Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas D DeBouver"'
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the s
Externí odkaz:
https://doaj.org/article/117f01418524456e8457bbd3d23cdecf
Autor:
Nicholas D. DeBouver, Madison J. Bolejack, Taiwo E. Esan, Damian J. Krysan, Timothy J. Hagen, Jan Abendroth
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 79:137-143
The compound ethyl-adenosyl monophosphate ester (ethyl-AMP) has been shown to effectively inhibit acetyl-CoA synthetase (ACS) enzymes and to facilitate the crystallization of fungal ACS enzymes in various contexts. In this study, the addition of ethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddaf2bcf56d804e8430cfa56c5c44959
https://doi.org/10.1107/s2053230x23003801
https://doi.org/10.1107/s2053230x23003801
Autor:
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M. Jude, Iva Marković, Rameshwar U. Kadam, Koen H. G. Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D. DeBouver, Allison Pires, Asim K. Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A. Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N. Savvides, K. Christopher Garcia, David Baker
Publikováno v:
NATURE
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab523f5e18cc78b7c277b545d214fda8
https://doi.org/10.1038/s41586-022-04654-9
https://doi.org/10.1038/s41586-022-04654-9
Autor:
Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Publikováno v:
mBio. 13
Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essential and con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d5e3691f424b12df939e277bf0aabc
https://doi.org/10.1128/mbio.01049-22
https://doi.org/10.1128/mbio.01049-22
Autor:
Jan Abendroth, Katy M Alden, Jameson Bullen, Taiwo E Esan, Timothy J. Hagen, Damian J. Krysan, Nicholas D DeBouver, Daniel M Murante, Andrew J. Jezewski, Brandy Calhoun, David A. Fox, Kristy T Potts
Publikováno v:
ACS Chemical Biology
Acetyl CoA synthetases (ACSs) are Acyl-CoA/NRPS/Luciferase (ANL) superfamily enzymes that couple acetate with CoA to generate acetyl CoA, a key component of central carbon metabolism in eukaryotes and prokaryotes. Normal mammalian cells are not depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b112a328679570b35d241bb455583c3
https://pubmed.ncbi.nlm.nih.gov/34369755
https://pubmed.ncbi.nlm.nih.gov/34369755