Cardiac Effects of a Novel pH-Insensitive Sodium-Calcium Exchanger Mouse

Autor: Rui Zhang, Xiaokang Wu, Brian Kim, Catherine Xie, Devina Gonzalez, Raven Norris, Nicholas Chin, Liang Li, Scott John, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber

BACKGROUNDCardiac sodium-calcium exchange (NCX1) is the dominant calcium (Ca) efflux mechanism in cardiomyocytes and is strongly regulated by pH. However, the role of NCX1 pH sensitivity in normal cardiac function is unknown.METHODSWe used CRISPR/Cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::048b5688c811204fc4913975c7adf0bd
https://doi.org/10.1101/2023.05.11.540465

Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Autor: Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte

Publikováno v: Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-24 (2024)

Abstract Background The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (propensity of lumefant

Externí odkaz: https://doaj.org/article/b7101befa7854b3099085d7a62c0dc08

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

Autor: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N. Gopalakrishna Iyer, Eliza Li Shan Fong

Publikováno v: Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)

Abstract Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐associated fibroblasts (CAFs) beyond previously established single‐gene markers. Functional analyses of individual CAF subsets within the tumor microe

Externí odkaz: https://doaj.org/article/29d702fb4fab4690857b4ee587c042cf

Craniofacial features as assessed by lateral cephalometric measurements in children with Down syndrome

Autor: Veerasathpurush Allareddy, Nicholas Ching, Eric A. Macklin, Lauren Voelz, Gil Weintraub, Emily Davidson, Lisa Albers Prock, Dennis Rosen, Richard Brunn, Brian G. Skotko

Publikováno v: Progress in Orthodontics, Vol 17, Iss 1, Pp 1-12 (2016)

Abstract Objective The objective of the present study is to examine the craniofacial development of patients with Down syndrome (DS) and compare them with a neurotypical population. Methods This study is a cross-sectional analysis of lateral cephalom

Externí odkaz: https://doaj.org/article/5ee531b42eb04ff5974c40103c6a161a

Healthcare in the era of climate change and the need for environmental sustainability.

Autor: Tee NCH; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Yeo JA; Duke-NUS Medical School, Singapore.; Department of Anaesthesia and Surgical Intensive Care, Changi General Hospital, Singapore., Choolani M; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Obstetrics and Gynaecology, National University Hospital, Singapore., Poh KK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Cardiology, National University Hospital, Singapore., Ang TL; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.; Duke-NUS Medical School, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Publikováno v: Singapore medical journal [Singapore Med J] 2024 Apr 01; Vol. 65 (4), pp. 204-210. Date of Electronic Publication: 2024 Apr 23.