Výsledky vyhledávání - "Nicholas Chester"

Akademický článek

Development and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

Autor: Sho Yoshimoto, Nicholas Chester, Ailian Xiong, Enrico Radaelli, Hong Wang, Marc Brillantes, Gayathri Gulendran, Patrick Glassman, Don L. Siegel, Nicola J. Mason

Publikováno v: mAbs, Vol 15, Iss 1 (2023)

ABSTRACTPD-1 checkpoint inhibitors have revolutionized the treatment of patients with different cancer histologies including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients show a dramatic clinica

Externí odkaz: https://doaj.org/article/e2cc3ba3c4cc456f979a67ebfed7ed7f

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Akademický článek

Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

Autor: Nicola J. Mason, Nicholas Chester, Ailian Xiong, Antonia Rotolo, Ying Wu, Sho Yoshimoto, Patrick Glassman, Gayathri Gulendran, Don L. Siegel

Publikováno v: mAbs, Vol 13, Iss 1 (2021)

The immune checkpoint inhibitor (ICI) ipilimumab has revolutionized the treatment of patients with different cancer histologies, including melanoma, renal cell carcinoma, and non-small cell lung carcinoma. However, only a subset of patients shows dra

Externí odkaz: https://doaj.org/article/3d1a06698fe447c889e66b51ed9b5518

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Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors

Autor: Ailian Xiong, Patrick M. Glassman, Nicholas Chester, Don L. Siegel, Sho Yoshimoto, Ying Wu, Antonia Rotolo, Nicola J. Mason, Gayathri Gulendran

Publikováno v: mAbs
article-version (VoR) Version of Record

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76245777eb331b5533fad4d0b591a4f8
https://doi.org/10.1080/19420862.2021.2004638

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The Bloom's Syndrome Helicase Is Critical for Development and Function of the αβ T-Cell Lineage

Autor: Philip Leder, Boris Reizis, Nicholas Chester, Holger Babbe

Publikováno v: Molecular and Cellular Biology. 27:1947-1959

Bloom's syndrome is a genetic disorder characterized by increased incidence of cancer and an immunodeficiency of unknown origin. The BLM gene mutated in Bloom's syndrome encodes a DNA helicase involved in the maintenance of genomic integrity. To expl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b75a600883a11b24ed4024a8cde77a
https://doi.org/10.1128/mcb.01402-06

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Chromosome instability and tumor predisposition inversely correlate with BLM protein levels

Autor: Mark J. Watson, Roger A. Schultz, Alexander D. Borowsky, Lisa D. McDaniel, Philip Leder, Nicholas Chester

Publikováno v: DNA Repair. 2:1387-1404

Independent mouse models for Bloom syndrome (BS) exist, each thought to disrupt Blm gene function. However, animals bearing these alleles exhibit distinct phenotypes. Blm tm1Ches and Blm tm1Grdn homozygous mutant animals exhibit embryonic lethality w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979d0850c92487efa70529f1388023e8
https://doi.org/10.1016/j.dnarep.2003.08.006

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Identification and Characterization of Protein Kinase CKII Isoforms in HeLa Cells

Autor: Nicholas Chester, Daniel R. Marshak, Il Je Yu

Publikováno v: Journal of Biological Chemistry. 270:7501-7514

Protein kinase CKII (formerly casein kinase II) can be isolated as a heterotetramer, containing two catalytic (alpha or alpha') and two regulatory (beta) subunits. We have characterized the forms of CKII in HeLa cells using antibodies specific for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::071f911d1643b385843f2ae3ef452f47
https://doi.org/10.1074/jbc.270.13.7501

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Mutation of the murine Bloom's syndrome gene produces global genome destabilization

Autor: Philip Leder, Nicholas Chester, Holger Babbe, Charlene Manning, Jan Pinkas

Publikováno v: Molecular and cellular biology. 26(17)

Bloom's syndrome (BS) is a genetic disorder characterized cellularly by increases in sister chromatid exchanges (SCEs) and numbers of micronuclei. BS is caused by mutation in the BLM DNA helicase gene and involves a greatly enhanced risk of developin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bf2e0d846de66401d18dc59cba94e0
https://pubmed.ncbi.nlm.nih.gov/16914751

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Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom’s syndrome gene

Autor: Nicholas Chester, Christine A. Kozak, Philip Leder, Cathie D. O’Hara, Frank C. Kuo

Bloom’s syndrome is a human autosomal genetic disorder characterized at the cellular level by genome instability and increased sister chomatid exchanges (SCEs). Clinical features of the disease include proportional dwarfism and a predisposition to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7fc9fdc674cd817dadd9415d5d1386
https://europepmc.org/articles/PMC317228/

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