Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Nicholas Charles Ray"'
Autor:
Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini
Publikováno v:
Journal of medicinal chemistry. 64(16)
Breast cancer remains a leading cause of cancer death in women, representing a significant unmet medical need. Here, we disclose our discovery efforts culminating in a clinical candidate, 35 (GDC-9545 or giredestrant). 35 is an efficient and potent s
Autor:
John Liu, Stephanie Addo, Gauri Deshmukh, Wyne P. Lee, Mark Zak, Ivan Peng, Hart S. Dengler, Julia Lloyd, Simon Charles Goodacre, Nicholas Charles Ray, Eric Suto, Pawan Bir Kohli, Savita Ubhayakar, Cristine M. Quiason-Huynh, Xiumin Wu, Cornelia H. Rinderknecht, Sheerin K. Shahidi-Latham, Youngsu Kwon, Marya Liimatta, Janet Jackman, Gary Cain, Jane R. Kenny, Gary Salmon, Brent S. McKenzie, Mike Briggs, Adam R. Johnson, Kathy Barrett, Nico Ghilardi
Publikováno v:
Science translational medicine. 10(468)
Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because