Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Nicholas C. Sturgess"'
Autor:
Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botham
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164094 (2016)
The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was ad
Externí odkaz:
https://doaj.org/article/f994ce1641f14c128b4b02f13f570ad2
Autor:
Philip A. Botham, Merrill O. Tisdel, James M. Mathews, Andrew R. Cook, Kim Z. Travis, Jeffrey C. Wolf, Dan Zadory, Charles B. Breckenridge, Daniel J. Minnema, Mark T. Butt, Melissa J. Beck, Smith Ll, Nicholas C. Sturgess
Publikováno v:
NeuroToxicology. 37:1-14
The pharmacokinetics and neurotoxicity of paraquat dichloride (PQ) were assessed following once weekly administration to C57BL/6J male mice by intraperitoneal injection for 1, 2 or 3 weeks at doses of 10, 15 or 25 mg/kg/week. Approximately 0.3% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566f4157863460a61190dea54d046f5d
Autor:
Nicholas C. Sturgess, Mark T. Butt, Philip A. Botham, Kim Z. Travis, Charles B. Breckenridge, Lewis L. Smith, Yun Jiao, Dan Zadory, Richard J. Smeyne, Jeffrey C. Wolf, Andrew R. Cook, Melissa J. Beck, Daniel J. Minnema
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164094 (2016)
PLoS ONE
PLoS ONE
The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b54ed58547ce3c04963d90df9abb021
http://europepmc.org/articles/PMC5082881?pdf=render
http://europepmc.org/articles/PMC5082881?pdf=render
Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides
Autor:
Steve Symington, Larry R. Holden, J. Marshall Clark, Larry P. Sheets, Nicholas C. Sturgess, Charles B. Breckenridge, Jin-Sung Choi, David M. Soderlund, Myra L. Weiner, Steve Burr, Dana Sargent, David E. Ray
Publikováno v:
NeuroToxicology. 30:S17-S31
Neurotoxicity and mechanistic data were collected for six alpha-cyano pyrethroids (beta-cyfluthrin, cypermethrin, deltamethrin, esfenvalerate, fenpropathrin and lambda-cyhalothrin) and up to six non-cyano containing pyrethroids (bifenthrin, S-bioalle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfa24d99ed3f7022da14fb351c05aef
https://doi.org/10.1016/j.neuro.2009.09.002
https://doi.org/10.1016/j.neuro.2009.09.002
Autor:
Nicholas C. Sturgess, Charles B. Breckenridge, Philip A. Botham, Kim Z. Travis, Andrew R. Cook, Daniel J. Minnema
Publikováno v:
Laboratory Investigation. 96:1028-1029
Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b45caaf4b6af76058337cc93edef8a3
https://doi.org/10.1038/labinvest.2016.80
https://doi.org/10.1038/labinvest.2016.80
Publikováno v:
Toxicology. 139:27-37
The monohalomethane methyl iodide (MeI) is toxic to a number of organ systems including the central nervous system. Clinical symptoms of neurotoxicity suggest that the cerebellum is the target within the brain, and we have now modelled the toxicity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b78082ca474a540de68b1c37ceb8c0d
https://doi.org/10.1016/s0300-483x(99)00099-2
https://doi.org/10.1016/s0300-483x(99)00099-2
Autor:
Melissa J. Beck, Dan Zadory, Kim Z. Travis, Mark Butt, Daniel J. Minnema, Nicholas C. Sturgess, Lewis L. Smith, Merrill O. Tisdel, Charles B. Breckenridge, Andrew R. Cook, Philip A. Botham, James M. Mathews, Jeffrey C. Wolf
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 68(2)
Several investigations have reported that mice administered paraquat dichloride (PQ·Cl2) by intraperitoneal injection exhibit a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In this study, male and female C57BL/6J mice w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68b2d4a34f2eabaa69810c9d0967887
https://pubmed.ncbi.nlm.nih.gov/24389362
https://pubmed.ncbi.nlm.nih.gov/24389362
Publikováno v:
Ciba Foundation Symposium 153-Steroids and Neuronal Activity
The effect of some endogenous and synthetic steroids on the operation of inhibitory and excitatory amino acid neurotransmitter receptors was examined. Anaesthetic pregnane steroids (e.g. alphaxalone, 5 alpha-pregnan-3 alpha-ol-20-one, 5 alpha-pregnan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b0cbc99db88d13c419eb1d948362fab
https://doi.org/10.1002/9780470513989.ch4
https://doi.org/10.1002/9780470513989.ch4
Publikováno v:
Neurotoxicology. 22(3)
Daily oral administration of 2.3 mmol/kg l -2-chloropropionic acid ( l -2-CPA), dl -2-bromopropionic acid (2-BPA) or dl -2-iodopropionic acid (2-IPA) but not dl -2-fluoropropionic acid (2-FPA) produced cerebellar granule cell necrosis in the rat. Twe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18ff346e6d5ef1f80fb7c7633b41ac2
https://pubmed.ncbi.nlm.nih.gov/11456337
https://pubmed.ncbi.nlm.nih.gov/11456337
Publikováno v:
Archives of toxicology. 74(3)
L-2-Chloropropionic acid (L-CPA), when administered orally to rats, produces selective necrosis to the granule cell layer of the rat cerebellum which is delayed in onset, not appearing until 36-48 h after exposure. The present study was conducted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2aa2b23bb304672096a18dadbec6369
https://pubmed.ncbi.nlm.nih.gov/10877001
https://pubmed.ncbi.nlm.nih.gov/10877001