Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nicholas C. Sennett"'
Autor:
Nicholas C. Sennett, Nicholas D. Keul, Gregory S. Custer, Richard M. Walsh, Zachary A. Wood, Andrew M. Sidlo, Renuka Kadirvelraj
Publikováno v:
Biochemistry. 53:8043-8051
Human UDP-α-d-glucose-6-dehydrogenase (hUGDH) displays hysteresis because of a slow isomerization from an inactive state (E*) to an active state (E). Here we show that the structure of E* constrains hUGDH in a conformation that favors feedback inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2671532d1ff3211607e3b4a7a3a8c5e
https://doi.org/10.1021/bi500594x
https://doi.org/10.1021/bi500594x
Autor:
Robert S. Phillips, Gregory S. Custer, Renuka Kadirvelraj, Zachary A. Wood, Nicholas C. Sennett
Publikováno v:
Biochemistry. 52:1456-1465
Human UDP-α-d-glucose 6-dehydrogenase (hUGDH) forms a hexamer that catalyzes the NAD(+)-dependent oxidation of UDP-α-d-glucose (UDG) to produce UDP-α-d-glucuronic acid. Mammalian UGDH displays hysteresis (observed as a lag in progress curves), ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108d4e65d081bb3b48db190f13a208a3
https://doi.org/10.1021/bi301593c
https://doi.org/10.1021/bi301593c
Publikováno v:
Biochemistry. 50:9651-9663
UDP-α-D-xylose (UDX) acts as a feedback inhibitor of human UDP-α-D-glucose 6-dehydrogenase (hUGDH) by activating an unusual allosteric switch, the Thr131 loop. UDX binding induces the Thr131 loop to translate ~5 Å through the protein core, changin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b083caacf8c2b7b1f7120f6c2525be80
https://doi.org/10.1021/bi201381e
https://doi.org/10.1021/bi201381e
Publikováno v:
Biochemistry. 51(46)
Human UDP-α-D-glucose dehydrogenase (hUGDH) catalyzes the NAD(+)-dependent oxidation of UDP-α-D-glucose (UDG) to produce UDP-α-D-glucuronic acid. The oligomeric structure of hUGDH is dynamic and can form two distinct hexameric complexes in solutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d86456ad42dbd8333ed3068fe63eca
https://pubmed.ncbi.nlm.nih.gov/23106432
https://pubmed.ncbi.nlm.nih.gov/23106432
Autor:
Stephen E. Weitzel, Samuel J. Polizzi, Renuka Kadirvelraj, Nicholas C. Sennett, Zachary A. Wood
Publikováno v:
Biochemistry. 50(25)
Allosteric feedback inhibition is the mechanism by which metabolic end products regulate their own biosynthesis by binding to an upstream enzyme. Despite its importance in controlling metabolism, there are relatively few allosteric mechanisms underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6107068d30b0a80e753f4fd6d0bc7b
https://pubmed.ncbi.nlm.nih.gov/21595445
https://pubmed.ncbi.nlm.nih.gov/21595445
Autor:
Nicholas C. Sennett, Renuka Kadirvelraj, Zachary A. Wood, Gregory S. Custer, Robert S. Phillips
Publikováno v:
Biochemistry. 54:629-629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf7cd97e912c20ff0c038a80e5c78c3c
https://doi.org/10.1021/bi501527p
https://doi.org/10.1021/bi501527p