Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Nicholas C. O. Tomkinson"'
Autor:
Dawn R. Chaffey, Carla Alamillo-Ferrer, Thomas E. Davies, Stuart H. Taylor, Nicholas C. O. Tomkinson, Andrew E. Graham
Publikováno v:
ACS Omega, Vol 4, Iss 14, Pp 15985-15991 (2019)
Externí odkaz:
https://doaj.org/article/34d5e0fa79c842929b22bae4910c465d
Autor:
Cinta Diez-Ardanuy, Jennifer Greaves, Kevin R. Munro, Nicholas C. O. Tomkinson, Luke H. Chamberlain
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Autosomal-dominant adult-onset neuronal ceroid lipofuscinosis (ANCL) is caused by mutation of the DNAJC5 gene encoding cysteine string protein alpha (CSPα). The disease-causing mutations, which result in substitution of leucine-115 with an
Externí odkaz:
https://doaj.org/article/2a20638872464157949edca61f2db773
Autor:
Henry J. Braddick, William J. Tipping, Liam T. Wilson, Harry S. Jaconelli, Emma K. Grant, Karen Faulds, Duncan Graham, Nicholas C. O. Tomkinson
Publikováno v:
Analytical Chemistry. 95:5369-5376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8202396ee9f5f8d8ca29ab4db97bcba2
https://doi.org/10.1021/acs.analchem.2c05708
https://doi.org/10.1021/acs.analchem.2c05708
Autor:
Ross P. Thomas, Emma K. Grant, Eleanor R. Dickinson, Francesca Zappacosta, Lee J. Edwards, Michael M. Hann, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Publikováno v:
RSC Medicinal Chemistry. 14:671-679
We present a carboxylate-targeting reactive fragment screening platform using 2-aryl-5-carboxytetrazole (ACT) as the photoreactive functionality. This work will provide a simple accessible method to rapidly discover tool molecules to interrogate impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3b68948d6bbe3fe003bc8768957b21
https://doi.org/10.1039/d2md00453d
https://doi.org/10.1039/d2md00453d
Autor:
Sergej Maciuk, Susanna H. Wood, Vipulkumar K. Patel, Peter D. P. Shapland, Nicholas C. O. Tomkinson
Publikováno v:
Chemistry – A European Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a36416e44ad5a5e96c7b9d0c81d4e7
https://doi.org/10.1002/chem.202204007
https://doi.org/10.1002/chem.202204007
Autor:
Arron Aatkar, Aini Vuorinen, Oliver E. Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D. Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-wa Chung, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Publikováno v:
ACS Chemical Biology.
Sulfur(VI) fluorides (SFs) have emerged as valuable electrophiles for the design of 'beyond cysteine' covalent inhibitors, and offer potential for expansion of the liganded proteome. Since SFs target a broad range of nucleophilic amino acids, they de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549ee29bfb50bf0d4a55e881a9deeae
https://doi.org/10.1021/acschembio.3c00034
https://doi.org/10.1021/acschembio.3c00034
Autor:
William J. Tipping, Liam T. Wilson, Connie An, Aristea A. Leventi, Alastair W. Wark, Corinna Wetherill, Nicholas C. O. Tomkinson, Karen Faulds, Duncan Graham
Publikováno v:
Chemical Science. 13:3468-3476
Statins have displayed significant, although heterogeneous, anti-tumour activity in breast cancer disease progression and recurrence. They offer promise as a class of drugs, normally used for cardiovascular disease control, that could have a signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484f1c5b5f979053594391bbcdf225d1
https://doi.org/10.1039/d1sc06976d
https://doi.org/10.1039/d1sc06976d
Autor:
Marcus Bantscheff, Christian Eberl, Chun-wa Chung, Nicholas C. O. Tomkinson, Stephanie Lehmann, Ken G. M. Fantom, Jacob T. Bush, Alex Phillipou, Christopher J. Schofield, Francesca Zappacosta, David J. Fallon, Vipulkumar Kantibhai Patel
Publikováno v:
Chemistry – A European Journal. 27:17880-17888
We present a one-step Ugi reaction protocol for the expedient synthesis of photoaffinity probes for live-cell MS-based proteomics. The reaction couples an amine affinity function with commonly used photoreactive groups, and a variety of handle functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79025963083ff808e540ac30b35fa0
https://doi.org/10.1002/chem.202102036
https://doi.org/10.1002/chem.202102036
Autor:
Emma K. Grant, Francesca Zappacosta, Peter Pogány, Michael M. Hann, Nicholas C. O. Tomkinson, David House, Ross P. Thomas, Jacob T. Bush, David J. Fallon, Rachel E. Heap, Stephen Besley
Publikováno v:
Chemical Science
Methods for rapid identification of chemical tools are essential for the validation of emerging targets and to provide medicinal chemistry starting points for the development of new medicines. Here, we report a screening platform that combines ‘dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c329d190f9f1199ac07fac7c57d5ee73
http://europepmc.org/articles/PMC8457371
http://europepmc.org/articles/PMC8457371
Autor:
William J. Tipping, Andrew S. Merchant, Rebecca Fearon, Nicholas C. O. Tomkinson, Karen Faulds, Duncan Graham
Publikováno v:
RSC chemical biology. 3(9)
Stimulated Raman scattering (SRS) microscopy is a powerful technique for visualising the cellular uptake and distribution of drugs and small molecules in live cells under biocompatible imaging conditions. The use of bio-orthogonal groups within the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1c74d9ea8b5c3ae1c969539aa06085
https://pubmed.ncbi.nlm.nih.gov/36128503
https://pubmed.ncbi.nlm.nih.gov/36128503