Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Nicholas C Firth"'
Autor:
Alexandra L Young, Razvan V Marinescu, Neil P Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C Firth, David M Cash, David L Thomas, Katrina M Dick, Jorge Cardoso, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Jason D Warren, Sebastian Crutch, Nick C Fox, Sebastien Ourselin, Jonathan M Schott, Jonathan D Rohrer, Daniel C Alexander, The Genetic FTD Initiative (GENFI), The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal
Externí odkaz:
https://doaj.org/article/edb6d5c8fa064af8b4704e322938446c
Autor:
Paul M. Camic, Sebastian J. Crutch, Charlie Murphy, Nicholas C. Firth, Emma Harding, Charles R. Harrison, Susannah Howard, Sarah Strohmaier, Janneke Van Leewen, Julian West, Gill Windle, Selina Wray, Hannah Zeilig
Publikováno v:
Frontiers in Psychology, Vol 9 (2018)
Creativity research has a substantial history in psychology and related disciplines; one component of this research tradition has specifically examined artistic creativity. Creativity theories have tended to concentrate, however, on creativity as an
Externí odkaz:
https://doaj.org/article/1e3357e2e8234c06b84fa66ed4fc10a2
Autor:
Neil P. Oxtoby, Sara Garbarino, Nicholas C. Firth, Jason D. Warren, Jonathan M. Schott, Daniel C. Alexander, For the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative diseases relate the pattern of pathology severity to the brain’s connectivity matrix, which reveals information about how pathology propagates through the connect
Externí odkaz:
https://doaj.org/article/db4345dec8a84626ab793348f4c061f7
Autor:
Sara Garbarino, Ann Blandford, Annemie Ribbens, Daniel C. Alexander, Dominic Furniss, Nicholas C. Firth, Neil P. Oxtoby, Maura Bellio
Publikováno v:
ACM Transactions on Computing for Healthcare. 2:1-19
Clinical decision-support tools (DSTs) represent a valuable resource in healthcare. However, lack of Human Factors considerations and early design research has often limited their successful adoption. To complement previous technically focused work,
Autor:
Ivanna M. Pavisic, Nicholas C. Firth, Samuel Parsons, David Martinez Rego, Timothy J. Shakespeare, Keir X. X. Yong, Catherine F. Slattery, Ross W. Paterson, Alexander J. M. Foulkes, Kirsty Macpherson, Amelia M. Carton, Daniel C. Alexander, John Shawe-Taylor, Nick C. Fox, Jonathan M. Schott, Sebastian J. Crutch, Silvia Primativo
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
Young onset Alzheimer’s disease (YOAD) is defined as symptom onset before the age of 65 years and is particularly associated with phenotypic heterogeneity. Atypical presentations, such as the clinic-radiological visual syndrome posterior cortical a
Externí odkaz:
https://doaj.org/article/618d527a49ed420190f2106b6bf540c1
Autor:
Timothy J. Shakespeare, Nick C. Fox, Keir Yong, Alexandra L. Young, Ross W. Paterson, Jason D. Warren, Amelia Carton, Aida Suarez-Gonzalez, Eulogio Gil-Néciga, Basil H. Ridha, Razvan V. Marinescu, Alexander J.M. Foulkes, Ivanna M. Pavisic, Daniel C. Alexander, Sebastien Ourselin, Elizabeth K. Warrington, Neil P. Oxtoby, Natalie S. Ryan, Dilek Ocal, Manja Lehmann, Nicholas C. Firth, Catherine F. Slattery, Marc Modat, Martin N. Rossor, Gil D. Rabinovici, Silvia Primativo, Bruce L. Miller, M. Jorge Cardoso, Jonathan M. Schott, Sebastian J. Crutch
Publikováno v:
Firth, N C, Primativo, S, Marinescu, R V, Shakespeare, T J, Suarez-Gonzalez, A, Lehmann, M, Carton, A, Ocal, D, Pavisic, I, Paterson, R W, Slattery, C F, Foulkes, A J M, Ridha, B H, Gil-Néciga, E, Oxtoby, N P, Young, A L, Modat, M, Cardoso, M J, Ourselin, S, Ryan, N S, Miller, B L, Rabinovici, G D, Warrington, E K, Rossor, M N, Fox, N C, Warren, J D, Alexander, D C, Schott, J M, Yong, K X X & Crutch, S J 2019, ' Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy ', Brain, vol. 142, no. 7, pp. 2082-2095 . https://doi.org/10.1093/brain/awz136
Digital.CSIC. Repositorio Institucional del CSIC
instname
Brain : a journal of neurology, vol 142, iss 7
Brain
Digital.CSIC. Repositorio Institucional del CSIC
instname
Brain : a journal of neurology, vol 142, iss 7
Brain
In the first multicentre, international longitudinal investigation of disease progression in posterior cortical atrophy, Firth et al. reveal distinct trajectories of cognitive decline and patterns of tissue loss compared to typical Alzheimer’s dise
Autor:
Amrita Mohan, Nicholas C. Firth, Sarah J. Tabrizi, Peter A. Wijeratne, Rachael I. Scahill, Razvan V. Marinescu, Daniel C. Alexander, Eileanoir B. Johnson, Cristina Sampaio, Neil P. Oxtoby, Alexandra L. Young
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Determining the sequence in which Huntington's disease biomarkers become abnormal can provide important insights into the disease progression and a quantitative tool for patient stratification. Here, we construct and present a uniquely fine
Autor:
Emilie V. Brotherhood, L.L. Daniel Lai, Rohan Takhar, Julian West, Nicholas C. Firth, Sebastian J. Crutch, Emma Harding, Paul M. Camic
Publikováno v:
Wellcome Open Research
Background: The current study sought to develop a valid, reliable and unobtrusive tablet computer-based observational measure to assess engagement of people with advanced dementia. The Video Analysis Scale of Engagement (VASE) was designed to enable
Autor:
Nicholas C. Firth, Alexandra L. Young, Emilie V. Brotherhood, Sebastian J. Crutch, Silvia Primativo, Neil P. Oxtoby, Keir X.X. Yong, Daniel C. Alexander
Publikováno v:
Alzheimer's & Dementia
Introduction This work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes. Methods Event-based modeling estimated fine-grained sequences of cognitive decline in clinically-diagnosed posterior cortical atrop
Autor:
Barbara Borroni, Neil P. Oxtoby, Maria Carmela Tartaglia, Sandro Sorbi, Martina Bocchetta, Jonathan M. Schott, Razvan V. Marinescu, Mario Masellis, Alexandre de Mendonça, Alexandra L. Young, Robert Laforce, Caroline Graff, Katrina M. Dick, Alzheimer’s Disease Neuroimaging Initiative, John C. van Swieten, Giovanni B. Frisoni, Sebastian J. Crutch, David M. Cash, Daniel C. Alexander, Jorge Cardoso, Jason D. Warren, Keir Yong, Daniela Galimberti, Fabrizio Tagliavini, Nick C. Fox, David L. Thomas, Jonathan D. Rohrer, Nicholas C. Firth, Sebastien Ourselin, Genetic Ftd Initiative Genfi, Elizabeth Finger, James B. Rowe
Publikováno v:
Medical Biophysics Publications
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Vol. 9, No 1 (2018) P. 4273
Nature Communications, 9:4273. Nature Publishing Group
Young, Alexandra L; Marinescu, Razvan V; Oxtoby, Neil P; Bocchetta, Martina; Yong, Keir; Firth, Nicholas C; et al.(2018). Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.. Nature communications, 9(1), 4273. doi: 10.1038/s41467-018-05892-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/87b1x37r
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, Vol. 9, No 1 (2018) P. 4273
Nature Communications, 9:4273. Nature Publishing Group
Young, Alexandra L; Marinescu, Razvan V; Oxtoby, Neil P; Bocchetta, Martina; Yong, Keir; Firth, Nicholas C; et al.(2018). Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.. Nature communications, 9(1), 4273. doi: 10.1038/s41467-018-05892-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/87b1x37r
The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning techni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172bdfce50541185157d28e1b5345699
https://ir.lib.uwo.ca/biophysicspub/617
https://ir.lib.uwo.ca/biophysicspub/617