Zobrazeno 1 - 10 of 106 pro vyhledávání: '"Nicholas C Denko"'
1
Akademický článek
Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival
Autor: Rituraj Upadhyay, Aastha Dhakal, Caroline Wheeler, Rebecca Hoyd, Malvenderjit Jagjit Singh, Vidhya Karivedu, Priyanka Bhateja, Marcelo Bonomi, Sasha Valentin, Mauricio E. Gamez, David J. Konieczkowski, Sujith Baliga, John C. Grecula, Dukagjin M. Blakaj, Emile Gogineni, Darrion L. Mitchell, Nicholas C. Denko, Daniel Spakowicz, Sachin R. Jhawar
Publikováno v: Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTHead and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response and prognosis. The tumor microenvironment (TME), which includes microbiome and immune cells, can impact outcomes. Here, we soug
Externí odkaz: https://doaj.org/article/9cd2a6b3a01a4b8fbe8b5d225ed3cc93
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2
Akademický článek
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways.
Autor: Donald Courter, Hongbin Cao, Shirley Kwok, Christina Kong, Alice Banh, Peiwen Kuo, Donna M Bouley, Carmen Vice, Odd Terje Brustugun, Nicholas C Denko, Albert C Koong, Amato Giaccia, Quynh-Thu Le
Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9633 (2010)
BackgroundHuman osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function. Here, we use genetic approaches to systematic
Externí odkaz: https://doaj.org/article/971290d025b14a0fbf44e879f81b25c1
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3
Akademický článek
Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect.
Autor: Yijun Chen, Rob Cairns, Ioanna Papandreou, Albert Koong, Nicholas C Denko
Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7033 (2009)
The unique metabolism of tumors was described many years ago by Otto Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial activity. However, "aerobic glycolysis" generates fewer ATP per glucose molecule than mitoc
Externí odkaz: https://doaj.org/article/8c0c43a4553c4b0fa183ddb87d295334
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8
Data from A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation
Autor: Albert C. Koong, Quynh-Thu Le, Amato J. Giaccia, Nicholas C. Denko, Constantinos Koumenis, Diego A.S. Toesca, David E. Solow-Cordero, Purvesh Khatri, Dadi Jiang, Jing Zhang, Zhifen Yang
Activation of the unfolded protein response (UPR) signaling pathways is linked to multiple human diseases, including cancer. The inositol-requiring kinase 1α (IRE1α)–X-box binding protein 1 (XBP1) pathway is the most evolutionarily conserved of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7181cd5b02073ec52e5627bd54e1ac99
https://doi.org/10.1158/1541-7786.c.6540322.v1
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10
Data from Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104
Autor: Nicholas C. Denko, Daniel T. Chang, Amato J. Giaccia, Edward E. Graves, Kevin L. Bennewith, Rob A. Cairns
Purpose: Solid tumors contain microenvironmental regions of hypoxia that present a barrier to traditional radiotherapy and chemotherapy, and this work describes a novel approach to circumvent hypoxia. We propose to overcome hypoxia by augmenting the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af4cda8054ab7a4a2a2b5e493a82db4
https://doi.org/10.1158/1078-0432.c.6517668
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