Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Nicholas C, Brecha"'
Autor:
Ashley M. Chen, Shaghauyegh S. Azar, Alexander Harris, Nicholas C. Brecha, Luis Pérez de Sevilla Müller
Publikováno v:
Frontiers in Neuroanatomy, Vol 15 (2021)
Manipulation of the phosphatase and tensin homolog (PTEN) pathway has been suggested as a therapeutic approach to treat or prevent vision loss due to retinal disease. In this study, we investigated the effects of deleting one copy of Pten in a well-c
Externí odkaz:
https://doaj.org/article/1e07bca4f9354e93b9aff2d999dc91cd
Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors
Autor:
Arlene A. Hirano, Helen E. Vuong, Helen L. Kornmann, Cataldo Schietroma, Salvatore L. Stella, Steven Barnes, Nicholas C. Brecha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Feedback inhibition by horizontal cells regulates rod and cone photoreceptor calcium channels that control their release of the neurotransmitter glutamate. This inhibition contributes to synaptic gain control and the formation of the center-surround
Externí odkaz:
https://doaj.org/article/a0c33ade00e54b5ebfac423249325d12
Publikováno v:
The Journal of Neuroscience. 43:2291-2304
Increasing spike rates drive greater neuronal energy demand. In turn, mitochondrial ATP production leads to the generation of reactive oxygen species (ROS) that can modulate ion channel gating. Does ROS production autoregulate the excitability of a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::affbea33be9c3429beccf9f4e5fd8694
https://doi.org/10.1523/jneurosci.1723-22.2023
https://doi.org/10.1523/jneurosci.1723-22.2023
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
How neurons in the eye feed signals back to photoreceptors to optimize sensitivity to patterns of light appears to be mediated by one or more unconventional mechanisms. Via these mechanisms, horizontal cells control photoreceptor synaptic gain and en
Externí odkaz:
https://doaj.org/article/5f08890d589444b9a45db5e5ffc07915
Autor:
Courtney A Burger, Jonathan Alevy, Anna K Casasent, Danye Jiang, Nicholas E Albrecht, Justine H Liang, Arlene A Hirano, Nicholas C Brecha, Melanie A Samuel
Publikováno v:
eLife, Vol 9 (2020)
Structural changes in pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap. Thus, it has been difficult to resolve which processes drive patterned connectivity. To overcome this, we use the laminated ou
Externí odkaz:
https://doaj.org/article/28945f0d1256418a9198f66526f7224a
Autor:
James C R Grove, Arlene A Hirano, Janira de Los Santos, Cyrus F McHugh, Shashvat Purohit, Greg D Field, Nicholas C Brecha, Steven Barnes
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000200 (2019)
The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal transmission. The mechanisms unde
Externí odkaz:
https://doaj.org/article/c9cd97c2e562426ba6a192bef22ae41e
Publikováno v:
Frontiers in Neuroanatomy, Vol 11 (2017)
The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina. Prox1 immunostaining was evaluated in
Externí odkaz:
https://doaj.org/article/f7f1e2bc8c2c43ae9dd80528eff3b0b7
Protective Effect of ALA in Crushed Optic Nerve Cat Retinal Ganglion Cells Using a New Marker RBPMS.
Autor:
Yanling Wang, Wenyao Wang, Jessica Liu, Xin Huang, Ruixing Liu, Huika Xia, Nicholas C Brecha, Mingliang Pu, Jie Gao
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160309 (2016)
In this study we first sought to determine whether RNA-binding protein with multiple splicing (RBPMS) can serve as a specific marker for cat retina ganglion cells (RGCs) using retrograde labeling and immunohistochemistry staining. RBPM was then used
Externí odkaz:
https://doaj.org/article/78f3758d5d9f4b5e843e6d088097eeec
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84507 (2014)
Aberrant calcium regulation has been implicated as a causative factor in the degeneration of retinal ganglion cells (RGCs) in numerous injury models of optic neuropathy. Since calcium has dual roles in maintaining homeostasis and triggering apoptotic
Externí odkaz:
https://doaj.org/article/2f91abbf7c414745ad0be34846f03a2c
Autor:
Ariel M Wilson, Vince A Chiodo, Sanford L Boye, Nicholas C Brecha, William W Hauswirth, Adriana Di Polo
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94175 (2014)
The transcription factor p53 mediates the apoptosis of post-mitotic neurons exposed to a wide range of stress stimuli. The apoptotic activity of p53 is tightly regulated by the apoptosis-stimulating proteins of p53 (ASPP) family members: ASPP1, ASPP2
Externí odkaz:
https://doaj.org/article/4ac4e6e017994c79b7f1f88d2f83bba0