Zobrazeno 1 - 10
of 37 713
pro vyhledávání: '"Nicholas C"'
Autor:
Jiaxi Zhao, Nicholas C. Lammers, Simon Alamos, Yang Joon Kim, Gabriella Martini, Hernan G. Garcia
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Transcriptional control is fundamental to cellular function. However, despite knowing that transcription factors can repress or activate specific genes, how these functions are implemented at the molecular level has remained elusive, particu
Externí odkaz:
https://doaj.org/article/b3d19fd36d704ae2969e0a285f177189
Autor:
Iris van ’t Erve, Bahar Alipanahi, Keith Lumbard, Zachary L. Skidmore, Lorenzo Rinaldi, Laurel K. Millberg, Jacob Carey, Bryan Chesnick, Stephen Cristiano, Carter Portwood, Tony Wu, Erica Peters, Karen Bolhuis, Cornelis J. A. Punt, Jennifer Tom, Peter B. Bach, Nicholas C. Dracopoli, Gerrit A. Meijer, Robert B. Scharpf, Victor E. Velculescu, Remond J. A. Fijneman, Alessandro Leal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Circulating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction,
Externí odkaz:
https://doaj.org/article/8005c4ee68144cd383ff212f1b67d00a
Autor:
Brian A. Derstine, Sven A. Holcombe, Nicholas C. Wang, Brian E. Ross, June A. Sullivan, Stewart C. Wang, Grace L. Su
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sarcopenia is the age-related loss of skeletal muscle mass and function. Computed tomography (CT) assessments of sarcopenia utilize measurements of skeletal muscle cross-sectional area (SMA), radiation attenuation (SMRA), and intramuscular a
Externí odkaz:
https://doaj.org/article/cf27e28dd0ac4301a07675765b959f21
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract New molecular technologies have helped unveil previously unexplored facets of the genome beyond the canonical proteome, including microproteins and short ORFs, products of alternative splicing, regulatory non-coding RNAs, as well as transpos
Externí odkaz:
https://doaj.org/article/7e789120f0cc458cb4e981523d048593
Autor:
Michael V. Heinz, Damien Lekkas, Veronica Abreu, Camilla Lee, Lisa A. Marsch, Nicholas C. Jacobson
Publikováno v:
npj Mental Health Research, Vol 3, Iss 1, Pp 1-14 (2024)
Abstract Depression and anxiety frequently co-occur with opioid use disorder (OUD) yet are often overlooked in standard OUD treatments. This study evaluated the feasibility, acceptability, and preliminary effectiveness of a mobile application designe
Externí odkaz:
https://doaj.org/article/2ad98788ca1c48c39cfc6b2054eb45a6
Autor:
Marta Pratelli, Anna M. Hakimi, Arth Thaker, Hyeonseok Jang, Hui-quan Li, Swetha K. Godavarthi, Byung Kook Lim, Nicholas C. Spitzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cognitive deficits are long-lasting consequences of drug use, yet the convergent mechanism by which classes of drugs with different pharmacological properties cause similar deficits is unclear. We find that both phencyclidine and methampheta
Externí odkaz:
https://doaj.org/article/ae571b8360e04b54843811fe5c4dadab
Autor:
Renee L. Hajnik, Jessica A. Plante, Srinivasa Reddy Bonam, Grace H. Rafael, Yuejin Liang, Nicholas C. Hazell, Jordyn Walker, Rachel A. Reyna, David H. Walker, Mohamad-Gabriel Alameh, Drew Weissman, Scott C. Weaver, Kenneth S. Plante, Haitao Hu
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract While first-generation, spike (S)-based COVID-19 vaccines were effective against early SARS-CoV-2 strains, the rapid evolution of novel Omicron subvariants have substantially reduced vaccine efficacy. As such, broadly protective vaccines aga
Externí odkaz:
https://doaj.org/article/e156f7e99f7a4151bd2453735a5ab1ac
Publikováno v:
Digital Biomarkers, Vol 8, Iss 1, Pp 181-193 (2024)
Introduction: Existing theories and empirical works link phone use with anxiety; however, most leverage subjective self-reports of phone use (e.g., validated questionnaires) that may not correspond well with true behavior. Moreover, most works linkin
Externí odkaz:
https://doaj.org/article/d53585d99d134088a5efc0343e818989
Autor:
Damien Lekkas, Nicholas C. Jacobson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Suicidal thought and behavior (STB) is highly stigmatized and taboo. Prone to censorship, yet pervasive online, STB risk detection may be improved through development of uniquely insightful digital markers. Focusing on Sanctioned Suicide, an
Externí odkaz:
https://doaj.org/article/8eab5ef2522a4d5c8da3c72cd042693c
Autor:
Anika L. Hurst, Allison L. O′Brien, Nicole D. Miller, Allysen M. Welty Peachey, James M. Yoder, Stefano G. De Faveri, Jodie Cheesman, Nicholas C. Manoukis, Matthew S. Siderhurst
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Determining movement parameters for pest insects such as tephritid fruit flies is critical to developing models which can be used to increase the effectiveness of surveillance and control strategies. In this study, harmonic radar was used to
Externí odkaz:
https://doaj.org/article/647c3ba12f8647c3a192c88582343228