Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nicholas Bbosa"'
Autor:
Maria Nannyonjo, Jonah Omooja, Daniel Lule Bugembe, Nicholas Bbosa, Sandra Lunkuse, Stella Esther Nabirye, Faridah Nassolo, Hamidah Namagembe, Andrew Abaasa, Anne Kazibwe, Pontiano Kaleebu, Deogratius Ssemwanga
Publikováno v:
Viruses, Vol 16, Iss 9, p 1454 (2024)
We assessed the performance and clinical relevance of Illumina MiSeq next-generation sequencing (NGS) for HIV-1 genotyping compared with Sanger sequencing (SS). We analyzed 167 participants, 45 with virologic failure (VL ≥ 1000 copies/mL), i.e., ca
Externí odkaz:
https://doaj.org/article/b792f59b6c27452286465c7b91a1fdb0
Autor:
Nicholas Bbosa, Deogratius Ssemwanga, Hamidah Namagembe, Ronald Kiiza, Jocelyn Kiconco, John Kayiwa, Tom Lutalo, Julius Lutwama, Alfred Ssekagiri, Isaac Ssewanyana, Susan Nabadda, Henry Kyobe-Bbosa, Jennifer Giandhari, Sureshnee Pillay, Upasana Ramphal, Yajna Ramphal, Yeshnee Naidoo, Derek Tshiabuila, Houriiyah Tegally, Emmanuel J. San, Eduan Wilkinson, Tulio de Oliveira, Pontiano Kaleebu
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1021-1025 (2022)
Genomic surveillance in Uganda showed rapid replacement of severe acute respiratory syndrome coronavirus 2 over time by variants, dominated by Delta. However, detection of the more transmissible Omicron variant among travelers and increasing communit
Externí odkaz:
https://doaj.org/article/c722de1348544f1c9e7a5461c191f850
Autor:
Jonah Omooja, Nicholas Bbosa, Dan Bugembe Lule, Maria Nannyonjo, Sandra Lunkuse, Faridah Nassolo, Stella Esther Nabirye, Hamidah Namagembe Suubi, Pontiano Kaleebu, Deogratius Ssemwanga
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background HIV-1 drug resistance genotyping is critical to the monitoring of antiretroviral treatment. Data on HIV-1 genotyping success rates of different laboratory specimen types from multiple sources is still scarce. Methods In this cross
Externí odkaz:
https://doaj.org/article/57bd1d1319e241339db0c1b70caf5522
Autor:
Hassan W. Kayondo, Alfred Ssekagiri, Grace Nabakooza, Nicholas Bbosa, Deogratius Ssemwanga, Pontiano Kaleebu, Samuel Mwalili, John M. Mango, Andrew J. Leigh Brown, Roberto A. Saenz, Ronald Galiwango, John M. Kitayimbwa
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful tools to reveal the population structure underlying an epidemic. Determining whether a
Externí odkaz:
https://doaj.org/article/f921303b4ec8402c97778b1b59c8ee53
Autor:
Nicholas Bbosa, Deogratius Ssemwanga, Rebecca N. Nsubuga, Noah Kiwanuka, Bernard S. Bagaya, John M. Kitayimbwa, Alfred Ssekagiri, Gonzalo Yebra, Pontiano Kaleebu, Andrew Leigh-Brown
Publikováno v:
Viruses, Vol 13, Iss 6, p 970 (2021)
Phylogenetic inference is useful in characterising HIV transmission networks and assessing where prevention is likely to have the greatest impact. However, estimating parameters that influence the network structure is still scarce, but important in e
Externí odkaz:
https://doaj.org/article/fc3705248a3c450ba145d3a28aa79a71
Autor:
Deogratius Ssemwanga, Nicholas Bbosa, Rebecca N. Nsubuga, Alfred Ssekagiri, Anne Kapaata, Maria Nannyonjo, Faridah Nassolo, Alex Karabarinde, Joseph Mugisha, Janet Seeley, Gonzalo Yebra, Andrew Leigh Brown, Pontiano Kaleebu
Publikováno v:
Viruses, Vol 12, Iss 11, p 1283 (2020)
The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003–2015 were analysed using
Externí odkaz:
https://doaj.org/article/496d307ce75240cca7f09d961e3351e5
Autor:
Nicholas Bbosa, Deogratius Ssemwanga, Alfred Ssekagiri, Xiaoyue Xi, Yunia Mayanja, Ubaldo Bahemuka, Janet Seeley, Deenan Pillay, Lucie Abeler-Dörner, Tanya Golubchik, Christophe Fraser, Pontiano Kaleebu, Oliver Ratmann, on behalf of the MRC/UVRI & LSHTM Uganda Research Unit and The PANGEA Consortium
Publikováno v:
Viruses, Vol 12, Iss 3, p 331 (2020)
Across sub-Saharan Africa, key populations with elevated HIV-1 incidence and/or prevalence have been identified, but their contribution to disease spread remains unclear. We performed viral deep-sequence phylogenetic analyses to quantify transmission
Externí odkaz:
https://doaj.org/article/9a586a88d44e4e02934c6bc31ce2f23f
Autor:
Maria Nannyonjo, Jonah Omooja, Daniel Lule Bugembe, Nicholas Bbosa, Sandra Lunkuse, Stella Esther Nabirye, Faridah Nassolo, Hamidah Namagembe, Andrew Abaasa, Anne Kazibwe, Pontiano Kaleebu, Deogratius Ssemwanga
Introduction Because next-generation sequencing (NGS) can detect minority mutations that have been linked to treatment failure but are missed by population Sanger sequencing, it has the potential to enhance HIV treatment monitoring. Comparing NGS bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4837a18808efa788eb1850ef77f5a450
https://doi.org/10.21203/rs.3.rs-2741155/v1
https://doi.org/10.21203/rs.3.rs-2741155/v1
Autor:
Samuel Mwalili, Hassan W. Kayondo, Andrew J. Leigh Brown, Ronald Galiwango, John Magero Mango, Nicholas Bbosa, Roberto A. Saenz, Alfred Ssekagiri, Pontiano Kaleebu, John M Kitayimbwa, Grace Nabakooza, Deogratius Ssemwanga
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-20 (2021)
Kayondo, H W, Ssekagiri, A, Nabakooza, G, Bbosa, N, Ssemwanga, D, Kaleebu, P, Mwalili, S, Mango, J M, Leigh Brown, A J, Saenz, R A, Galiwango, R & Kitayimbwa, J M 2021, ' Employing phylogenetic tree shape statistics to resolve the underlying host population structure ', BMC Bioinformatics, vol. 22, no. 1, 546 . https://doi.org/10.1186/s12859-021-04465-1
BMC Bioinformatics
Kayondo, H W, Ssekagiri, A, Nabakooza, G, Bbosa, N, Ssemwanga, D, Kaleebu, P, Mwalili, S, Mango, J M, Leigh Brown, A J, Saenz, R A, Galiwango, R & Kitayimbwa, J M 2021, ' Employing phylogenetic tree shape statistics to resolve the underlying host population structure ', BMC Bioinformatics, vol. 22, no. 1, 546 . https://doi.org/10.1186/s12859-021-04465-1
BMC Bioinformatics
Background Host population structure is a key determinant of pathogen and infectious disease transmission patterns. Pathogen phylogenetic trees are useful tools to reveal the population structure underlying an epidemic. Determining whether a populati
Autor:
Stella E Nabirye, Pontiano Kaleebu, Faridah Nassolo, Daniel Lule Bugembe, Nicholas Bbosa, Farouk Segujja, Jonah Omooja, Janet Seeley, Deogratius Ssemwanga, Maria Nanyonjo, Rebecca N Nsubuga, William Ssenyonga, David P. Kateete, Yunia Mayanja, Sandra Lunkuse
Publikováno v:
AIDS Research and Human Retroviruses. 36:782-791
HIV drug resistance (HIVDR) is of increasing health concern, especially among key populations. We investigated the prevalence of virological suppression (VS), prevalence and correlates of HIVDR in HIV-infected women, enrolled in a high-risk cohort. W