Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nicholas Barlow"'
Autor:
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J. Gunzburg, Catherine F. Latham, Nicholas Barlow, George W. Mbogo, Paula Ellenberg, Stephen J. Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D. Bauman, Francesc X. Ruiz, Eddy Arnold, David K. Chalmers, Gilda Tachedjian
Publikováno v:
Molecules, Vol 28, Iss 7, p 3103 (2023)
Human immunodeficiency virus type I (HIV-1) is a retrovirus that infects cells of the host’s immune system leading to acquired immunodeficiency syndrome and potentially death. Although treatments are available to prevent its progression, HIV-1 rema
Externí odkaz:
https://doaj.org/article/c7cd4c19945d4662b4ccbad1fae4b33e
Autor:
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270584 (2022)
Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies have indicated that GzmK activates protease-activated receptor 1 (PAR1) enhancing activation o
Externí odkaz:
https://doaj.org/article/2543c7da6a754a3fa2d4be5da6c98eab
Autor:
Vladimir Kuklin, Nurlan Akhatov, Timofei Kondratiev, Aidos Konkayev, Abai Baigenzhin, Maiya Konkayeva, Temirlan Karibekov, Nicholas Barlow, Torkjel Tveita, Vegard Dahl
Publikováno v:
BMC Anesthesiology, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background In different models of hypoxia, blockade of opioid or N-methyl-D-aspartate (NMDA) receptors shows cardio- and neuroprotective effects with a consequent increase in animal survival. The aim of the study was to investigate effects o
Externí odkaz:
https://doaj.org/article/810ea3120689498db997f360376822dc
Autor:
Nicholas Barlow, Philip E. Thompson
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders. To date, a number of IRAP inhibitor designs have been investigated but the total nu
Externí odkaz:
https://doaj.org/article/497995a1ce054905a6c3e4352637f11d
Autor:
Sandeep Chhabra, Nicholas Barlow, Olan Dolezal, Meghan K Hattarki, Janet Newman, Thomas S Peat, Bim Graham, James D Swarbrick
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59535 (2013)
As the second essential enzyme of the folate biosynthetic pathway, the potential antimicrobial target, HPPK (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase), catalyzes the Mg(2+-)dependant transfer of pyrophosphate from the cofactor (ATP) to the
Externí odkaz:
https://doaj.org/article/5a6586f22089478595d16b4c92edf595
Autor:
Rebecca Ward, Ruchi Choudary, Melanie Jans Singh, Flora Roumpani, Tomas Lazauskas, May Yong, Nicholas Barlow, Markus Hauru
Publikováno v:
Journal of Building Performance Simulation. :1-22
Autor:
Wenxiao K. Yue, Tianxia Zhang, Rekha Shandre Mugan, Nicholas Barlow, David K. Chalmers, Colin W. Pouton, Philip E. Thompson
Publikováno v:
Journal of Medicinal Chemistry. 66:3273-3283
Publikováno v:
Radiography. 29:119-123
Patient positioning may impact diagnostic quality when obtaining radiographs of the musculoskeletal (MSK) system. Hence, knowledge on patient positioning, as seen in the radiograph, followed by informed adjusted retake if appropriate, is key when und
Autor:
Billy J. Williams-Noonan, Melissa N. Speer, Tu C. Le, Maiada M. Sadek, Philip E. Thompson, Raymond S. Norton, Elizabeth Yuriev, Nicholas Barlow, David K. Chalmers, Irene Yarovsky
Publikováno v:
Journal of Chemical Information and Modeling. 62:4605-4619
The ability to predict cell-permeable candidate molecules has great potential to assist drug discovery projects. Large molecules that lie beyond the Rule of Five (bRo5) are increasingly important as drug candidates and tool molecules for chemical bio
Autor:
Arfatur Rahman, Macgregor A. Matthews, Cameron J. Nowell, David K. Chalmers, Philip E. Thompson, Sandra E. Nicholson, Nicholas Barlow, Raymond S. Norton
Publikováno v:
Bioorganic chemistry. 123
The SPRY domain-containing SOCS box protein-2 (SPSB2) plays a critical role in the degradation of inducible nitric oxide synthase (iNOS) in macrophages. In this study, we have conjugated a peptide inhibitor of the iNOS-SPSB2 interaction with a cell-p