Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicholas B. Woodall"'
Autor:
Meaghan A. Valliere, Tyler P. Korman, Nicholas B. Woodall, Gregory A. Khitrov, Robert E. Taylor, David Baker, James U. Bowie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Producing individual cannabinoids by metabolically engineered microbes has proven challenging. Here, the authors develop a cell-free enzymatic prenylating system to generate isoprenyl pyrophosphate substrates directly from glucose and produce both co
Externí odkaz:
https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
Autor:
Meaghan A. Valliere, Tyler P. Korman, Nicholas B. Woodall, Gregory A. Khitrov, Robert E. Taylor, David Baker, James U. Bowie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
In the original version of this Article, the genotype of the M30 mutant presented in Fig. 3b was given incorrectly as Y288V/A232S, and the M31 mutant was given incorrectly as M1/A232S. The correct genotype of the M30 mutant is Y288A/A232S and for M31
Externí odkaz:
https://doaj.org/article/6f029ec8655a4654b94ece5ae0d798c1
Engineered proteins with precisely defined shapes can scaffold functional protein domains in 3D space to fine-tune their functions, such as the regulation of cellular signaling by ligand positioning or the design of self-assembling protein materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bde6724851e0f8c405874ea8beb683e
https://doi.org/10.1101/2023.05.24.542095
https://doi.org/10.1101/2023.05.24.542095
Autor:
David Baker, Robert E. Taylor, Tyler P. Korman, Meaghan Valliere, James U. Bowie, Gregory A. Khitrov, Nicholas B. Woodall
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have a low natural abundance, alternative production methods are needed. Metabolic engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010f6a2f2729b9c13fa61288b26d4879
https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
https://doaj.org/article/91846144fed24fbd93ae5a96ab7c927a
Autor:
Carl P. Goodrich, Nicholas B. Woodall, Alexis Courbet, Ofer Kimchi, David Baker, Agnese Curatolo, Michael Brenner
Publikováno v:
Science Advances
Mathematical models for two experimentally realizable posttranslational protein oscillators are constructed.
Recent advances in synthetic posttranslational protein circuits are substantially impacting the landscape of cellular engineering and of
Recent advances in synthetic posttranslational protein circuits are substantially impacting the landscape of cellular engineering and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a053ebb64e26311ac94ed99f342dd1a0
https://doi.org/10.1126/sciadv.abc1939
https://doi.org/10.1126/sciadv.abc1939
Autor:
Issa Yousif, Vicki H. Wysocki, Nicholas B. Woodall, David Baker, Richard S. Johnson, Michael E. P. Murphy, Florian Busch, Jesslyn E Park, Zara Y. Weinberg, Maggie Ahlrichs, Hana El-Samad, Michael J. MacCoss, Mikayla J Feldbauer
Publikováno v:
Nat Struct Mol Biol
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45df16d22a4b92fb0aeb29e3524629eb
https://pubmed.ncbi.nlm.nih.gov/34518698
https://pubmed.ncbi.nlm.nih.gov/34518698
Autor:
Alexis Courbet, Ofer Kimchi, David Baker, Agnese Curatolo, Michael Brenner, Carl P. Goodrich, Nicholas B. Woodall
Recent advances in synthetic post-translational protein circuits are significantly impacting the landscape of biomimicry engineering. However, designing sustained dynamic phenomena in these circuits remains an outstanding challenge. Inspired by the K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a4c50af6d8fd7ebbb4bbfab0ec010a
Publikováno v:
Protein Science. 26:824-833
The topology of helical membrane proteins is generally defined during insertion of the transmembrane helices, yet it is now clear that it is possible for topology to change under unusual circumstances. It remains unclear, however, if topology reorien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05bbe87a0ad9c615959d6b23a1ba14fb
https://doi.org/10.1002/pro.3131
https://doi.org/10.1002/pro.3131
Autor:
Tyler P. Korman, Robert E. Taylor, David Baker, Gregory A. Khitrov, James U. Bowie, Nicholas B. Woodall, Meaghan Valliere
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Prenylation of natural compounds adds structural diversity, alters biological activity, and enhances therapeutic potential. Because prenylated compounds often have a low natural abundance, alternative production methods are needed. Metabolic engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b78d1b77e691f8ac51370bc2edccc1a
http://link.springer.com/article/10.1038/s41467-019-10436-1
http://link.springer.com/article/10.1038/s41467-019-10436-1
Publikováno v:
Biophysical Journal. 110(3)
Some membrane transporters are dual topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear. For the dual-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f7df221c99fb25b944d2db90706428