Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nicholas B. Raffaele"'
Autor:
Brett C. Bookser, Nicholas B. Raffaele
Publikováno v:
Journal of Combinatorial Chemistry. 10:567-572
A high-throughput phosphoramidite method for HepDirect prodrug synthesis was optimized on seven representative nucleosides, adenosine, inosine, guanosine, uridine, cytidine, AICA-riboside, and thymidine, each on a 5 mg scale. The variables optimized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db5e340f1edead027b3eb773dcc0c59
https://doi.org/10.1021/cc8000212
https://doi.org/10.1021/cc8000212
Autor:
Brett C. Bookser, Nicholas B. Raffaele
Publikováno v:
The Journal of Organic Chemistry. 72:173-179
The Vorbrüggen glycosylation reaction was adapted into a one-step 5 min/130 degrees C microwave assisted reaction. Triethanolamine in acetontrile containing 2% water was determined to be optimal for the neutralization of trimethylsilyl triflate allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e938f89072e5d3e6029c139915c71290
https://doi.org/10.1021/jo061885l
https://doi.org/10.1021/jo061885l
Autor:
Fabrice Pierre, Adam Siddiqui-Jain, Jeffrey P. Whitten, Ryan Stansfield, Levan Darjania, Cosmin Borsan, Sean O'Brien, Tran Joe, Chris Proffitt, May Omori, William G. Rice, Mustapha Haddach, Kenna Anderes, Nicholas B. Raffaele, Michael K. Schwaebe, Joshua R. Bliesath, Nicole Streiner, Suchitra Ravula, Diwata Macalino, Denis Drygin, Jerome Michaux, David M. Ryckman
Publikováno v:
ACS medicinal chemistry letters. 3(2)
Structure–activity relationship analysis in a series of 3-(5-((2-oxoindolin-3-ylidene)methyl)furan-2-yl)amides identified compound 13, a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. Compound 13 exhibited in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df43fa65795ab6b23c07ba2ecc4b4594
https://pubmed.ncbi.nlm.nih.gov/24900437
https://pubmed.ncbi.nlm.nih.gov/24900437
Autor:
Brett C. Bookser, K. Raja Reddy, Mark D. Erion, Wenjian Huang, Nicholas B. Raffaele, Kevin Fan
Publikováno v:
ChemInform. 41
The synthesis of 3′-amino-3′-deoxyguanosine and 3′-amino-3′-deoxyxyloguanosine monophosphate HepDirect prodrugs from guanosine is reported. Initial incorporation of N,N-dibenzylformamidino protection of the C2-amino of guanosine masked the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4c0eea88d9cf366d46d6d09b8d4f8ef
https://doi.org/10.1002/chin.201015198
https://doi.org/10.1002/chin.201015198
Autor:
Kevin Fan, K. Raja Reddy, Mark D. Erion, Brett C. Bookser, Nicholas B. Raffaele, Wenjian Huang
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 28(10)
The synthesis of 3'-amino-3'-deoxyguanosine and 3'-amino-3'-deoxyxyloguanosine monophosphate HepDirect prodrugs from guanosine is reported. Initial incorporation of N,N-dibenzylformamidino protection of the C2-amino of guanosine masked the reactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f235fa8313dbd0edacd5e0af8e389d4
https://pubmed.ncbi.nlm.nih.gov/20183565
https://pubmed.ncbi.nlm.nih.gov/20183565