Výsledky vyhledávání - "Nicholas B. La Thangue"

Akademický článek

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Autor: Wojciech Barczak, Simon M. Carr, Geng Liu, Shonagh Munro, Annalisa Nicastri, Lian Ni Lee, Claire Hutchings, Nicola Ternette, Paul Klenerman, Alexander Kanapin, Anastasia Samsonova, Nicholas B. La Thangue

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses wh

Externí odkaz: https://doaj.org/article/23d754b5fcb74be2b6886c3854660ad7

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Akademický článek

The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

Autor: Geng Liu, Wojciech Barczak, Lian Ni Lee, Amit Shrestha, Nicholas M. Provine, Gulsah Albayrak, Hong Zhu, Claire Hutchings, Paul Klenerman, Nicholas B. La Thangue

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.

Externí odkaz: https://doaj.org/article/677c416326a64b9dac386ff4677a2afa

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Akademický článek

Immune modulation underpins the anti‐cancer activity of HDAC inhibitors

Autor: Wiktoria Blaszczak, Geng Liu, Hong Zhu, Wojciech Barczak, Amit Shrestha, Gulsah Albayrak, Shunsheng Zheng, David Kerr, Anastasia Samsonova, Nicholas B. La Thangue

Publikováno v: Molecular Oncology, Vol 15, Iss 12, Pp 3280-3298 (2021)

Aberrant protein acetylation is strongly linked to tumorigenesis, and modulating acetylation through targeting histone deacetylase (HDAC) with small‐molecule inhibitors has been the focus of clinical trials. However, clinical success on solid tumou

Externí odkaz: https://doaj.org/article/44339e57e4864182884b12445438ede8

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Akademický článek

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

Autor: Shonagh Munro, Edward S. Hookway, Melanie Floderer, Simon M. Carr, Rebecca Konietzny, Benedikt M. Kessler, Udo Oppermann, Nicholas B. La Thangue

Publikováno v: Cell Reports, Vol 19, Iss 11, Pp 2193-2201 (2017)

The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner

Externí odkaz: https://doaj.org/article/ee5d94d2d69c46e49403b4c9d84fd915

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Akademický článek

Linking H1 with chromatin and growth control

Autor: Shonagh Munro, Nicholas B. La Thangue

Publikováno v: Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)

The retinoblastoma protein (pRb) is considered to be one of the key regulators of cell proliferation. Here we describe our recent findings that linker histone H1.2 is an interaction partner for pRb and impacts upon the genome-wide chromatin binding p

Externí odkaz: https://doaj.org/article/f92b81b0574445058658e883f107808c

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Akademický článek

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

Autor: Sophia X. Pfister, Sara Ahrabi, Lykourgos-Panagiotis Zalmas, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday, Gaëlle Legube, Nicholas B. La Thangue, Andrew C.G. Porter, Timothy C. Humphrey

Publikováno v: Cell Reports, Vol 7, Iss 6, Pp 2006-2018 (2014)

Modulating chromatin through histone methylation orchestrates numerous cellular processes. SETD2-dependent trimethylation of histone H3K36 is associated with active transcription. Here, we define a role for H3K36 trimethylation in homologous recombin

Externí odkaz: https://doaj.org/article/8726864a3199418d93dcad631056782e

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