Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Nicholas Arpaia"'
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Autor:
Candice R. Gurbatri, Georgette A. Radford, Laura Vrbanac, Jongwon Im, Elaine M. Thomas, Courtney Coker, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin R. M. Lannagan, Tongtong Wang, Josephine A. Wright, Hiroki Kobayashi, Jia Q. Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Alexandra M. Stavropoulos, Dion A. Gouskos, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L. Worthley, Susan L. Woods, Tal Danino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli Niss
Externí odkaz:
https://doaj.org/article/16a3783ebc994816bc3440bb05df9c6f
Autor:
Mathieu Rouanne, Julien Adam, Camélia Radulescu, Diane Letourneur, Delphine Bredel, Séverine Mouraud, Anne-Gaëlle Goubet, Marion Leduc, Noah Chen, Tuan Zea Tan, Nicolas Signolle, Amélie Bigorgne, Michael Dussiot, Lambros Tselikas, Sandrine Susini, François-Xavier Danlos, Anna K. Schneider, Roman Chabanon, Sophie Vacher, Ivan Bièche, Thierry Lebret, Yves Allory, Jean-Charles Soria, Nicholas Arpaia, Guido Kroemer, Oliver Kepp, Jean Paul Thiery, Laurence Zitvogel, Aurélien Marabelle
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Patients with high-risk, nonmuscle-invasive bladder cancer (NMIBC) frequently relapse after standard intravesical bacillus Calmette-Guérin (BCG) therapy and may have a dismal outcome. The mechanisms of resistance to such immunotherapy remain poorly
Externí odkaz:
https://doaj.org/article/d3133523389b44ef89a70120d1393a04
Publikováno v:
European Journal of Cancer. 187:58-64
Autor:
Candice R. Gurbatri, Georgette Radford, Laura Vrbanac, Courtney Coker, Jong-won Im, Samuel R. Taylor, YoungUk Jang, Ayelet Sivan, Kyu Rhee, Anas A. Saleh, Tiffany Chien, Fereshteh Zandkarimi, Ioana Lia, Tamsin RM Lannagan, Tongtong Wang, Josephine A Wright, Elaine Thomas, Hiroki Kobayashi, Jia Q Ng, Matt Lawrence, Tarik Sammour, Michelle Thomas, Mark Lewis, Lito Papanicolas, Joanne Perry, Tracy Fitzsimmons, Patricia Kaazan, Amanda Lim, Julie Marker, Cheri Ostroff, Geraint Rogers, Nicholas Arpaia, Daniel L Worthley, Susan L Woods, Tal Danino
Publikováno v:
bioRxiv
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60062672f0b39d77dd9740b766a751
https://europepmc.org/articles/PMC10104002/
https://europepmc.org/articles/PMC10104002/
Autor:
Thomas M. Savage, Rosa L. Vincent, Sarah S. Rae, Lei Haley Huang, Alexander Ahn, Kelly Pu, Fangda Li, Kenia de los Santos-Alexis, Courtney Coker, Tal Danino, Nicholas Arpaia
Publikováno v:
Science Advances. 9
Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an inability to target therapeutics specifically to the tumor. Synthetic biology enab
Autor:
Tetsuhiro Harimoto, Jaeseung Hahn, Yu-Yu Chen, Jongwon Im, Joanna Zhang, Nicholas Hou, Fangda Li, Courtney Coker, Kelsey Gray, Nicole Harr, Sreyan Chowdhury, Kelly Pu, Clare Nimura, Nicholas Arpaia, Kam W. Leong, Tal Danino
Publikováno v:
Nature Biotechnology. 40:1259-1269
Living bacteria therapies have been proposed as an alternative approach to treating a broad array of cancers. In this study, we developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular pol
Publikováno v:
Science (New York, N.Y.). 378(6622)
With increasing evidence that microbes colonize tumors, synthetic biology tools are being leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered systems can modulate the tumor microenvironment using a combination of thei
Autor:
Katherine A. Kaiser, Lucas F. Loffredo, Kenia de los Santos-Alexis, Olivia R. Ringham, Nicholas Arpaia
Publikováno v:
The Journal of experimental medicine. 220(3)
Following respiratory viral infection, regeneration of the epithelial barrier is required to preserve lung function and prevent secondary infections. Lung regulatory T (Treg) cells are critical for maintaining blood oxygenation following influenza vi
Autor:
Thomas M. Savage, Rosa L. Vincent, Sarah S. Rae, Lei Haley Huang, Alexander Ahn, Kelly Pu, Fangda Li, Courtney Coker, Tal Danino, Nicholas Arpaia
Tumors employ multiple mechanisms to actively exclude or suppress adaptive immune cells involved in anti-tumor immunity. Strategies focused on overcoming these immunosuppressive or exclusion signals – through localized delivery of chemokines that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de064e15d0e5693cbe95cd7471fda696
https://doi.org/10.1101/2022.06.16.496462
https://doi.org/10.1101/2022.06.16.496462
Autor:
Candice R. Gurbatri, Georgette Radford, Jongwon Im, Courtney Coker, Nicholas Arpaia, Susan L. Woods, Daniel L. Worthley, Tal Danino
Publikováno v:
Cancer Research. 83:6525-6525
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate selective colonization of CRC tumors with the orally-delivered probiotic E. coli Nissle 1917 (Ec