Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Nicholas AK"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Background: Drug discovery and development is the extremely costly and time-consuming process of identifying new molecules that can interact with a biomarker target to interrupt the disease pathway of interest. In addition to binding the tar
Externí odkaz:
https://doaj.org/article/13404294b3e3481a9863b450b88f3463
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Background Drug design is a challenging and important task that requires the generation of novel and effective molecules that can bind to specific protein targets. Artificial intelligence algorithms have recently showed promising potential t
Externí odkaz:
https://doaj.org/article/4e2ed60152f34aa3a9665f9dc8c02b1b
Autor:
Nicholas, AK, Jaleel, S, Lyons, G, Schoenmakers, E, Dattani, MT, Crowne, E, Bernhard, B, Kirk, J, Roche, EF, Chatterjee, VK, Schoenmakers, N
Publikováno v:
Clinical Endocrinology
Summary Objective Homozygous mutations in the TSH beta subunit gene (TSHB) result in severe, isolated, central congenital hypothyroidism (CCH). This entity evades diagnosis in TSH‐based congenital hypothyroidism (CH) screening programmes in the UK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5a9b7b8eb9a438c7e86cd79d8979c267
http://europepmc.org/articles/PMC5324561
http://europepmc.org/articles/PMC5324561
Autor:
Koulouri, O, Nicholas, AK, Schoenmakers, E, Mokrosinski, J, Lane, F, Cole, T, Kirk, J, Farooqi, IS, Chatterjee, VK, Gurnell, M, Schoenmakers, N
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
CONTEXT: Isolated central congenital hypothyroidism (CCH) is rare and evades diagnosis on TSH-based congenital hypothyroidism (CH) screening programs in the United Kingdom. Accordingly, genetic ascertainment facilitates diagnosis and treatment of fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::51cede82989427a9e511fa12f3afe455
http://europepmc.org/articles/PMC4803180
http://europepmc.org/articles/PMC4803180
Autor:
Benjamin Levens, M.D., Brian Sangwook Kim, B.S., Nicholas Aksu, B.S., C. Scott Dorris, M.L.I.S., Steven Svoboda, M.D., Col. (Ret.), Wiemi Douoguih, M.D., James Dreese, M.D.
Publikováno v:
Arthroscopy, Sports Medicine, and Rehabilitation, Vol 5, Iss 6, Pp 100817- (2023)
Purpose: To investigate orthopaedic patient compliance with patient-reported outcome measures (PROMs) and identify factors that improve response rates. Methods: Our search strategy comprised a combination of key words and database-specific subject he
Externí odkaz:
https://doaj.org/article/d007d1a9debe4cfb99a1b72cb36c309f
Publikováno v:
International Journal of Plant Based Pharmaceuticals, Vol 2, Iss 2, Pp 228-238 (2022)
Moringa oleifera is a medicinally important plant of the family Moringaceae, which is highly valued because of its enormous nutritional and therapeutic potential. Each part of M. oleifera is said to contain medicinal properties, which contributes to
Externí odkaz:
https://doaj.org/article/609a3eeab3c54cd180a48759d301202b
Autor:
Enoch Odame Anto, David Antony Coall, Emmanuel Akomanin Asiamah, Osei-Owusu Afriyie, Otchere Addai-Mensah, Yaw Amo Wiafe, Wkba Owiredu, Christian Obirikorang, Max Efui Annani-Akollor, Nicholas Akinwale Titiloye, Eric Adua, Emmanuel Acheampong, Evans Asamoah Adu, Stephen Opoku, Agartha Odame Anto, Augustine Tawiah, Youxin Wang, Wei Wang
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265717 (2022)
BackgroundAngiogenic growth mediators (AGMs) and oxidative stress (OS) both play essential roles in normal placental vascular development and as such, placental alterations in these factors contribute to pre-eclampsia (PE). Suboptimal health status (
Externí odkaz:
https://doaj.org/article/f8db8c041c8a49feb23bdaee5091927b
Autor:
Nicholas Akomeng, Stephen Adusei
Publikováno v:
Heliyon, Vol 7, Iss 11, Pp e08388- (2021)
Phenolic compounds are regarded as the most abundant plant metabolites that are known to decompose progressively into soils, likened to other soil organic materials. Once assimilated into soils, they can control soil processes, including organic matt
Externí odkaz:
https://doaj.org/article/19805daecfec4d5b9089faac93ecf6ff
Autor:
Bojan Losic, Amanda J. Craig, Carlos Villacorta-Martin, Sebastiao N. Martins-Filho, Nicholas Akers, Xintong Chen, Mehmet E. Ahsen, Johann von Felden, Ismail Labgaa, Delia DʹAvola, Kimaada Allette, Sergio A. Lira, Glaucia C. Furtado, Teresa Garcia-Lezana, Paula Restrepo, Ashley Stueck, Stephen C. Ward, Maria I. Fiel, Spiros P. Hiotis, Ganesh Gunasekaran, Daniela Sia, Eric E. Schadt, Robert Sebra, Myron Schwartz, Josep M. Llovet, Swan Thung, Gustavo Stolovitzky, Augusto Villanueva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterog
Externí odkaz:
https://doaj.org/article/b7e9387e6d0443a18b41f98ca9cd0d20
Autor:
Francis Opoku, Kweku Bedu-Addo, Nicholas Akinwale Titiloye, Elijah Atta Manu, Charity Ameh-Mensah, Babatunde Moses Duduyemi
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
Background Inactivation or mutation of the tumour suppressor gene p53 or its regulator mouse double minute 2 (MDM2) is the commonest event in breast cancer. These altered genes usually express abnormally high levels of their proteins in many carcinom
Externí odkaz:
https://doaj.org/article/0fcaee6959dd42d68317127498477eae