Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Nicholas A. Wallace"'
Autor:
Sebastian Wendel, Nicholas A. Wallace
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTThis review focuses on the impact of human papillomavirus (HPV) oncogenes on DNA repair pathways with a particular focus on how these relationships change as productive HPV infections transition to malignant lesions. We made specific efforts
Externí odkaz:
https://doaj.org/article/1f91727ea4364f5da9794ca4de8f87ae
Autor:
Dalton Dacus, Nicholas A. Wallace
Publikováno v:
Viruses, Vol 13, Iss 8, p 1662 (2021)
The beta genus of human papillomaviruses infects cutaneous keratinocytes. Their replication depends on actively proliferating cells and, thus, they conflict with the cellular response to the DNA damage frequently encountered by these cells. This revi
Externí odkaz:
https://doaj.org/article/b3c8f5d7adac4a7dbca2a6a8924022ca
Autor:
Nicholas A. Wallace
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Nicholas Wallace studies how human papillomaviruses cause cancer throughout the genital and oropharyngeal tracts as well as in the skin. These viruses inhibit host DNA repair to promote their life style and in doing increase the risk of onco
Externí odkaz:
https://doaj.org/article/c347e1d52e484eecb9bc2393a30df554
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
While the role of genus alpha human papillomaviruses in the tumorigenesis and tumor maintenance of anogenital and oropharyngeal cancers is well-established, the role of genus beta human papilloviruses (β-HPVs) in non-melanoma skin cancers (NMSCs) is
Externí odkaz:
https://doaj.org/article/acf8aa6b73204f7a8faf00c4a0c357ad
Autor:
Dalton Dacus, Steven Stancic, Sarah R. Pollina, Elizabeth Rifrogiate, Rachel Palinski, Nicholas A. Wallace
Publikováno v:
J Virol
Cutaneous beta genus human papillomaviruses (β-HPVs) are suspected to promote the development of nonmelanoma skin cancer (NMSC) by destabilizing the host genome. Multiple studies have established the genome destabilizing capacities of β-HPV protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3d4f04511ead89d836b544b8572139
https://doi.org/10.1128/jvi.01015-22
https://doi.org/10.1128/jvi.01015-22
Publikováno v:
International journal of molecular sciences. 23(15)
Translesion synthesis (TLS) is a cell signaling pathway that facilitates the tolerance of replication stress. Increased TLS activity, the particularly elevated expression of TLS polymerases, has been linked to resistance to cancer chemotherapeutics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3356da9411382f2545ab7addd47d838
https://pubmed.ncbi.nlm.nih.gov/35955705
https://pubmed.ncbi.nlm.nih.gov/35955705
Publikováno v:
Virology. 549:32-38
Human papillomavirus (HPV) is a family of viruses divided into five genera: alpha, beta, gamma, mu, and nu. There is an ongoing discussion about whether beta genus HPVs (β-HPVs) contribute to cutaneous squamous cell carcinoma (cSCC). The data presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cee5a3c3498a6b4ffe9f99938e54c0
https://doi.org/10.1016/j.virol.2020.07.016
https://doi.org/10.1016/j.virol.2020.07.016
Autor:
Andrew J. Holcomb, Rashna Madan, Yelizaveta Shnayder, Sufi M. Thomas, Laura E Brown, Ossama Tawfik, Nicholas A. Wallace
Publikováno v:
Virology
The incidence of head and neck squamous cell carcinomas (HNSCCs) is rising in developed countries. This is driven by an increase in HNSCCs caused by high-risk human papillomavirus (HPV) infections or HPV + HNSCCs. Compared to HNSCCs not caused by HPV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b538cc61f0f1e8b893074119dd17bdac
https://doi.org/10.1016/j.virol.2020.07.004
https://doi.org/10.1016/j.virol.2020.07.004
Autor:
Nicholas A. Wallace
Publikováno v:
Trends in Microbiology. 28:191-201
To replicate, the human papillomaviruses (HPVs) that cause anogenital and oropharyngeal malignancies must simultaneously activate DNA repair pathways and avoid the cell cycle arrest that normally accompanies DNA repair. For years it seemed that HPV o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f0858e4849ed4c9470ebc587f5cc19
https://doi.org/10.1016/j.tim.2019.10.008
https://doi.org/10.1016/j.tim.2019.10.008
Publikováno v:
Journal of Visualized Experiments.
Double strand breaks (DSBs) in DNA are the most cytotoxic type of DNA damage. Because a myriad of insults can result in these lesions (e.g., replication stress, ionizing radiation, unrepaired UV damage), DSBs occur in most cells each day. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801e71eb5694fa5a96b335fe98cb708
https://doi.org/10.3791/62583
https://doi.org/10.3791/62583