Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nicholas A. Pease"'
Autor:
Nicholas A. Pease, Phuc H.B. Nguyen, Marcus A. Woodworth, Kenneth K.H. Ng, Blythe Irwin, Joshua C. Vaughan, Hao Yuan Kueh
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108888- (2021)
Summary: During development, progenitors often differentiate many cell generations after receiving signals. These delays must be robust yet tunable for precise population size control. Polycomb repressive mechanisms, involving histone H3 lysine-27 tr
Externí odkaz:
https://doaj.org/article/7373c09769d246d48eff135d9a67e496
Publikováno v:
Immunol Rev
Proper timing of gene expression is central to lymphocyte development and differentiation. Lymphocytes often delay gene activation for hours to days after the onset of signaling components, which act on the order of seconds to minutes. Such delays pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3067e3b0a384449cc590155ff0d1ff
https://doi.org/10.1111/imr.12946
https://doi.org/10.1111/imr.12946
Autor:
Nicholas A Pease, Melissa L Baker, Holly R. Steach, Jim Boonyaratanakornkit, Marti R. Tooley, Allison Schwartz, Justin J. Taylor, Blair L DeBuysscher
Publikováno v:
J Immunol
Upon antigen exposure, naïve B cells expressing B cell receptors (BCR) able to bind antigen can undergo robust proliferation and differentiation that can result in the production of antibody-secreting and memory B cells. The factors determining whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d3724096102c33d7d03a210b9acfc4
https://doi.org/10.4049/jimmunol.1900799
https://doi.org/10.4049/jimmunol.1900799
Autor:
Hao Yuan Kueh, Phuc H.B. Nguyen, Nicholas A. Pease, Kenneth K.H. Ng, Marcus A. Woodworth, Aaron R. Halpern, Joshua C. Vaughan
Publikováno v:
Nucleic Acids Research
Proper regulation of genome architecture and activity is essential for the development and function of multicellular organisms. Histone modifications, acting in combination, specify these activity states at individual genomic loci. However, the metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf71e7b89e01e9da6c34f28a27bd54f
https://pubmed.ncbi.nlm.nih.gov/34048564
https://pubmed.ncbi.nlm.nih.gov/34048564
Publikováno v:
Curr Opin Syst Biol
To protect against diverse challenges, the immune system must continuously generate an arsenal of specialized cell types, each of which can mount a myriad of effector responses upon detection of potential threats. To do so, it must generate multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bde3b1890bbf989d21ef543338cbe3
https://pubmed.ncbi.nlm.nih.gov/33791444
https://pubmed.ncbi.nlm.nih.gov/33791444
Autor:
Miranda S. Shephard, Lisa M. Privette Vinnedge, Nicholas A. Pease, Mathieu Sertorio, Susan E. Waltz
Publikováno v:
Cancers
Volume 12
Issue 7
Cancers, Vol 12, Iss 1936, p 1936 (2020)
Volume 12
Issue 7
Cancers, Vol 12, Iss 1936, p 1936 (2020)
Breast cancer (BC) is the second leading cause of cancer deaths among women. DEK is a known oncoprotein that is highly expressed in over 60% of breast cancers and is an independent marker of poor prognosis. However, the molecular mechanisms by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6add16369afea919b5e211c07aaaab42
http://europepmc.org/articles/PMC7409092
http://europepmc.org/articles/PMC7409092
Autor:
Yash Patil, Lisa M. Privette Vinnedge, Trisha Wise-Draper, Julianne Qualtieri, Randall Butler, Adam Lane, Nicholas A. Pease, Jonathan Mark, Keith A. Casper, Sarah Palackdharry, Arun Sendilnathan, John C. Morris, Keith M. Wilson, Nooshin Hashemi Sadraei, Vinita Takiar
Publikováno v:
Translational Oncology, Vol 11, Iss 1, Pp 168-174 (2018)
Head and neck cancer (HNC) remains the sixth most common malignancy worldwide and survival upon recurrence and/or metastasis remains poor. HNSCC has traditionally been associated with alcohol and nicotine use, but more recently the Human Papilloma Vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91606785c53c8a75fa09455ec71a6677
http://www.sciencedirect.com/science/article/pii/S1936523317303856
http://www.sciencedirect.com/science/article/pii/S1936523317303856
Autor:
Christina M. Estrada, Matia B. Solomon, Valentina Ghisays, Joshua Streicher, Ana Franco-Villanueva, Nicholas A. Pease, Elizabeth T. Nguyen, Lisa M. Privette Vinnedge, Maureen Fitzgerald
Publikováno v:
Neuroscience. 371:254-267
DEK, a chromatin-remodeling gene expressed in most human tissues, is known for its role in cancer biology and autoimmune diseases. DEK depletion in vitro reduces cellular proliferation, induces DNA damage subsequently leading to apoptosis, and down-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee07c7986460ba754feba0546a29056
https://doi.org/10.1016/j.neuroscience.2017.11.025
https://doi.org/10.1016/j.neuroscience.2017.11.025
Publikováno v:
J R Soc Interface
During development, progenitor cells follow timetables for differentiation that span many cell generations. These developmental timetables are robustly encoded by the embryo, yet scalably adjustable by evolution, facilitating variation in organism si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46456e561e67c6fa28d05a0d031730a7
https://doi.org/10.1098/rsif.2021.0109
https://doi.org/10.1098/rsif.2021.0109
SummaryDuring development, progenitors follow defined temporal schedules for differentiation, to form organs and body plans with precise sizes and proportions. Across diverse contexts, these developmental schedules are encoded by autonomous timekeepi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea8a73c2d7ec561fa051c87ef3cffdf
