Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicholas A. Parejo"'
Autor:
John E. Palardy, Abdullah Chahin, Nicholas A. Parejo, David V. Jobes, David L. Horn, Steven M. Opal, Michelle Yamamoto, Yazan Migdady, Jorge Zorzopulos
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:1225-1229
IMT504 is a novel immunomodulatory oligonucleotide that has shown immunotherapeutic properties in early preclinical and clinical studies. IMT504 was tested in a neutropenic rat model of Pseudomonas aeruginosa bacteremia and sepsis. This animal system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cf03095d16f85f5a6326a7928e4974
https://doi.org/10.1128/aac.03923-14
https://doi.org/10.1128/aac.03923-14
Autor:
James L. Ellis, Abdulrahman Chahin, Johannes M. Freudenberg, Abdullah Chahin, Yong Li, Vipin Suri, John E. Palardy, Steven M. Opal, Michelle Yamamoto, George P. Vlasuk, Noubar Kessimian, Nicholas A. Parejo
Publikováno v:
Shock (Augusta, Ga.). 45(4)
The sirtuin family consists of seven NAD+-dependent enzymes affecting a broad array of regulatory protein networks by primarily catalyzing the deacetylation of key lysine residues in regulatory proteins. The enzymatic activity of SIRT1 can be enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbde4ee95e4c9915cabfdd8ff55baf75
https://pubmed.ncbi.nlm.nih.gov/26974318
https://pubmed.ncbi.nlm.nih.gov/26974318
Autor:
Nicholas A. Parejo, Wilbur H. Chen, Stephanie Mott, John E. Palardy, Christine A. Anderson, Alan S. Cross, Sara J. Heninger, Steven M. Opal, Andrew W. Artenstein, Stephen H. Gregory
Publikováno v:
Vaccine. 28:2908-2915
Francisella tularensis is a category A select agent. J5dLPS/OMP is a novel vaccine construct consisting of detoxified, O-polysaccharide side chain-deficient, lipopolysaccharide non-covalently complexed with the outer membrane protein of N. meningitid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc96928e0b1b05560755fcc90c942653
https://doi.org/10.1016/j.vaccine.2010.01.067
https://doi.org/10.1016/j.vaccine.2010.01.067
Autor:
Andrew W. Artenstein, Steven M. Opal, John E. Palardy, Yow-Pin Lim, Patricia Cristofaro, Nicholas A. Parejo, Jhung W. Jhung
Publikováno v:
Infection and Immunity. 73:5101-5105
Inter-alpha-inhibitor protein (IαIp) functions as an endogenous serine protease inhibitor in human plasma, and IαIp levels diminish rapidly during acute inflammatory states. One potential target for IαIp is furin, a cell-associated serine endopept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbb83d106e7d6ec9dfa2163b23427c9
https://doi.org/10.1128/iai.73.8.5101-5105.2005
https://doi.org/10.1128/iai.73.8.5101-5105.2005
Autor:
John E. Palardy, Jhung W. Jhung, Lynnette D. Young, Nicholas A. Parejo, Alan S. Cross, Steven M. Opal, Curtis Donsky
Publikováno v:
Journal of Infectious Diseases. 173:1415-1421
Using an actual infection model of Pseudomonas aeruginosa sepsis in neutropenic rats, the potential utility of a combination anticytokine approach for the treatment of sepsis was tested. A dimeric tumor necrosis factor binding protein (TNF-BP) consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4865d56a412e8db5cd7e4339e7df9276
https://doi.org/10.1093/infdis/173.6.1415
https://doi.org/10.1093/infdis/173.6.1415
Autor:
Kim Milarski, Nicholas A. Parejo, Brian M. Clancy, James C. Keith, Helen Palmer, Xiang-Yang Tan, Emily C Lutterloh, Steven M. Opal, John E. Palardy, Ying Ying Sun, Noubar Kessimian, Debra D. Pittman
Publikováno v:
Critical Care
Introduction The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis. Methods We studied the possible therapeutic role of R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890e4dbc00563c12d2092b9d30adc07c
https://pubmed.ncbi.nlm.nih.gov/18190725
https://pubmed.ncbi.nlm.nih.gov/18190725
Autor:
Steven M. Opal, Abdulrahman Chahin, Nicholas A. Parejo, Yazan Migdady, Michelle Yamamoto, Abdullah Chahin, John E. Palardy
Publikováno v:
Critical Care Medicine. 42:A1592
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a9d7e36387208e03fd32776f0c7b571
https://doi.org/10.1097/01.ccm.0000458462.31509.e4
https://doi.org/10.1097/01.ccm.0000458462.31509.e4
Publikováno v:
Critical Care Medicine. 42:A1605
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7584b08db6419529940cea6918de52ce
https://doi.org/10.1097/01.ccm.0000458515.15369.25
https://doi.org/10.1097/01.ccm.0000458515.15369.25