Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Nicholas A. May"'
Autor:
Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating
Externí odkaz:
https://doaj.org/article/dfff5e12899b43dd9c8db8e7247e88db
Autor:
David W. Hawman, Julie M. Fox, Alison W. Ashbrook, Nicholas A. May, Kristin M.S. Schroeder, Raul M. Torres, James E. Crowe Jr., Terence S. Dermody, Michael S. Diamond, Thomas E. Morrison
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1326-1338 (2016)
Chikungunya virus (CHIKV) and related alphaviruses cause epidemics of acute and chronic musculoskeletal disease. To investigate the mechanisms underlying the failure of immune clearance of CHIKV, we studied mice infected with an attenuated CHIKV stra
Externí odkaz:
https://doaj.org/article/a0c429574bbd4bd385c377b101b51d3c
Autor:
Alison W. Ashbrook, Anthony J. Lentscher, Paula F. Zamora, Laurie A. Silva, Nicholas A. May, Joshua A. Bauer, Thomas E. Morrison, Terence S. Dermody
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Chikungunya virus (CHIKV) is a reemerging alphavirus that has caused epidemics of fever, arthralgia, and rash worldwide. There are currently no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV disea
Externí odkaz:
https://doaj.org/article/14d88177dc7140fe8068a099bec59762
Publikováno v:
Viruses, Vol 8, Iss 10, p 287 (2016)
West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its
Externí odkaz:
https://doaj.org/article/109d36cc6e1c4c4e86eae15bd4b2a123
Autor:
Kathryn S Carpentier, Bennett J Davenport, Kelsey C Haist, Mary K McCarthy, Nicholas A May, Alexis Robison, Claudia Ruckert, Gregory D Ebel, Thomas E Morrison
Publikováno v:
eLife, Vol 8 (2019)
The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus transmission, geographic spread, and disease severity. We find that multiple alphaviruses, including chikungunya (CHIKV), Ross River (RRV), and o’nyong ‘nyong
Externí odkaz:
https://doaj.org/article/1bca733072e94419b0e3fbfbf08f37b9
Autor:
Hui Zhang, Evgenia Gerasimovskaya, Mary K. McCarthy, Nicholas A. May, Ram Raj Prasad, Suzette Riddle, B Alexandre McKeon, Sushil Kumar, Min Li, Cheng-Jun Hu, Maria G Frid, Thomas E. Morrison, Kurt R Stenmark
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology.
Autor:
Thomas E. Morrison, Stephanie A. Montgomery, Anthony J. Lentscher, Nicholas A May, Laurie A. Silva, Mary K. McCarthy, Bennett Davenport, Nicole McAllister, Terence S. Dermody, Krishnan Raghunathan
Publikováno v:
Journal of Clinical Investigation. 130:1466-1478
Chikungunya virus (CHIKV) is an arbovirus capable of causing a severe and often debilitating rheumatic syndrome in humans. CHIKV replicates in a wide variety of cell types in mammals, which has made attributing pathologic outcomes to replication at s
Autor:
Erin D. Lucas, Nicholas A May, Frances S. Li, Beth A. Jirón Tamburini, Cormac J. Lucas, Thomas E. Morrison, Mary K. McCarthy, Ryan M. Sheridan, Jay R. Hesselberth, Kathryn S. Carpentier, Glennys V. Reynoso, Bennett Davenport, Heather D. Hickman
Publikováno v:
The EMBO Journal. 40
Viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity. However, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for
Autor:
Kathryn S, Carpentier, Ryan M, Sheridan, Cormac J, Lucas, Bennett J, Davenport, Frances S, Li, Erin D, Lucas, Mary K, McCarthy, Glennys V, Reynoso, Nicholas A, May, Beth A J, Tamburini, Jay R, Hesselberth, Heather D, Hickman, Thomas E, Morrison
Publikováno v:
EMBO J
Viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity. However, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for
Autor:
Nathaniel J. Moorman, Nikhil Madadi, Daniel N. Streblow, Nicole N. Haese, Robert Bostwick, Mark T. Heise, Wes Sanders, Theresa H Nguyen, Corinne E. Augelli-Szafran, Nichole A Towers, Omar Moukha-Chafiq, Victor R. DeFilippis, Joseph A. Maddry, Sixue Zhang, Ashish K. Pathak, Mark J. Suto, Subramaniam Ananthan, Sharon Taft-Benz, Lynn Rasmussen, Shuklendu D Karyakarte, Michael Denton, Nicholas A May, Kevin J Rodzinak, Aaron D Streblow, Thomas E. Morrison
Publikováno v:
Antimicrob Agents Chemother
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that protected again