DNA-bridging by an archaeal histone variant via a unique tetramerisation interface

Autor: Sapir Ofer, Fabian Blombach, Amanda M. Erkelens, Declan Barker, Zoja Soloviev, Samuel Schwab, Katherine Smollett, Dorota Matelska, Thomas Fouqueau, Nico van der Vis, Nicholas A. Kent, Konstantinos Thalassinos, Remus T. Dame, Finn Werner

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-16 (2023)

Abstract In eukaryotes, histone paralogues form obligate heterodimers such as H3/H4 and H2A/H2B that assemble into octameric nucleosome particles. Archaeal histones are dimeric and assemble on DNA into ‘hypernucleosome’ particles of varying sizes

Externí odkaz: https://doaj.org/article/bc8d288a4e11401aafac8f1923d0ab56

Genome-wide chromatin mapping with size resolution reveals a dynamic sub-nucleosomal landscape in Arabidopsis.

Autor: Daniel Antony Pass, Emily Sornay, Angela Marchbank, Margaret R Crawford, Konrad Paszkiewicz, Nicholas A Kent, James A H Murray

Publikováno v: PLoS Genetics, Vol 13, Iss 9, p e1006988 (2017)

All eukaryotic genomes are packaged as chromatin, with DNA interlaced with both regularly patterned nucleosomes and sub-nucleosomal-sized protein structures such as mobile and labile transcription factors (TF) and initiation complexes, together formi

Externí odkaz: https://doaj.org/article/dcbcbbaa145e486a9fb801a2a37ca4f9

The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses.

Autor: Anna L Chambers, Peter M Brownlee, Samuel C Durley, Tracey Beacham, Nicholas A Kent, Jessica A Downs

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32016 (2012)

The RSC chromatin remodeling complex has been implicated in contributing to DNA double-strand break (DSB) repair in a number of studies. Both survival and levels of H2A phosphorylation in response to damage are reduced in the absence of RSC. Importan

Externí odkaz: https://doaj.org/article/96ff8c4d486d4d4fad19b6bc79ca0ac6

Functions of Archaeal Nucleoid Proteins: Archaeal Silencers are Still Missing

Autor: Taku Oshima, Hiromi Nishida, Hugo Maruyama, Nicholas A. Kent

Publikováno v: DNA Traffic in the Environment ISBN: 9789811334108

It is well known that horizontally transferred genes (HTGs) contribute to the adaptation of archaea to their living environment. Archaea have acquired HTGs not only from other archaea but also from bacteria. HTGs should be integrated into the host ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4a7a374ae50bddcccdbcf6cb6d3de2f
https://doi.org/10.1007/978-981-13-3411-5_2

Abo1, a conserved bromodomain AAA ‐ ATP ase, maintains global nucleosome occupancy and organisation

Autor: Csenge Gal, Lakxmi Subramanian, Robin C. Allshire, Karen M Moore, Alex J Whale, Konrad Paszkiewicz, Heather E. Murton, Kevin M. Creamer, Simon K. Whitehall, Sandra Codlin, Jürg Bähler, Nicholas A. Kent, Janet F. Partridge

Publikováno v: EMBO Reports
Gal, C, Murton, H E, Subramanian, L, Whale, A J, Moore, K M, Paszkiewicz, K, Codlin, S, Bähler, J, Creamer, K M, Partridge, J F, Allshire, R C, Kent, N A & Whitehall, S K 2016, ' Abo1, a conserved bromodomain AAA-ATPase, maintains global nucleosome occupancy and organisation ', EMBO Reports, vol. 17, no. 1, pp. 79-93 . https://doi.org/10.15252/embr.201540476

Maintenance of the correct level and organisation of nucleosomes is crucial for genome function. Here, we uncover a role for a conserved bromodomain AAA-ATPase, Abo1, in the maintenance of nucleosome architecture in fission yeast. Cells lacking abo1+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff026580cc269f457127eff006bfddac
https://doi.org/10.15252/embr.201540476