Výsledky vyhledávání - "Nicholas A. Forward"

Outcomes of High Grade B- Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements: An Atlantic Canadian Centre Perspective

Autor: Mary-Margaret Keating, Nicholas A. Forward, Erica Kelly

Publikováno v: Blood. 138:4579-4579

Background: High Grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (also known as Double-hit lymphoma (DHL)) is an aggressive B cell Non-Hodgkin lymphoma which has recently been recognized by the WHO as a distinct clinical entity fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b91f408b2f188d4751bfe1539f1b16a7
https://doi.org/10.1182/blood-2021-153585

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Targeted Deep Sequencing As a Clinically Effective Approach to Profile the Mutational Landscape in Multiple Myeloma

Autor: Philipp Knopf, Manal O. Elnenaei, Marissa Goudie, Andrea Thoni, Darrell White, Daniel Gaston, Nicholas Allen Forward, Samuel D. Cutler, Julie Wagner

Publikováno v: Blood. 136:37-38

Introduction: Multiple Myeloma (MM) is the second most common hematological malignancy in North America. It is characterized by invasion of the bone marrow by malignant plasma cells. This malignancy presents with a broad range of primary genomic lesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dd088d3159067ce517bca431054cd72
https://doi.org/10.1182/blood-2020-137754

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Low-depth sequencing for copy number abnormalities in multiple myeloma supersedes fluorescent in situ hybridization in scope and resolution

Autor: Mohamed Abou El Hassan, Wenda L. Greer, Nicholas A. Forward, Clinton J. V. Campbell, Samuel D. Cutler, Philipp Knopf, Manal O. Elnenaei, Julie Wagner, Daniel Gaston, Darrell White, Keaton Sinclair, Stephen Couban, Marissa Goudie

Publikováno v: Clinical genetics. 96(2)

Multiple myeloma (MM) is an incurable hematological malignancy that relies on cytogenetic determination of copy number abnormalities (CNAs) for prognosis and management. Low-depth whole genome sequencing (LD-WGS) is a cost-effective alternative to ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd218a80f26316258bcbeedb1410975
https://pubmed.ncbi.nlm.nih.gov/31066036

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Clinical Effectiveness of Combination Immunotherapy DPX-Survivac, Low Dose Cyclophosphamide, and Pembrolizumab in Recurrent/Refractory DLBCL: The Spirel Study

Autor: Irina Amitai, Gail Klein, Yogesh Bramhecha, Isabelle Bence-Bruckler, Iran Rashedi, Douglas A. Stewart, Joy Mangel, Rebekah Conlon, Pierre Laneuville, Neil L. Berinstein, Nancy Pennell, Kim Roos, Nicholas Allen Forward

Publikováno v: Blood. 136:16-16

Background: Recurrent/refractory (r/r) DLBCL presents a major treatment challenge, especially in the setting of patients who are ineligible for, or relapsing after, potentially curative treatments such as autologous stem cell transplant (ASCT) and ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed2e39b686253f418fab02c58e08a53d
https://doi.org/10.1182/blood-2020-136751

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Combination of DPX-Survivac, Low Dose Cyclophosphamide, and Pembrolizumab in Recurrent/Refractory DLBCL: The Spirel Study

Autor: Liam Smyth, Nicholas Allen Forward, Gail Klein, Isabelle Bence-Bruckler, Nancy Pennell, Pierre Laneuville, Douglas A. Stewart, Kim Roos, Neil L. Berinstein

Publikováno v: Blood. 134:3236-3236

Introduction: Recurrent/refractory diffuse large B cell lymphoma (DLBCL) remains an area of unmet clinical need. Although autologous stem cell transplant (ASCT), and more recently chimeric antigen receptor (CAR) T cell therapy, have made a significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de192470a76be5390262591393248ba
https://doi.org/10.1182/blood-2019-125963

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Regulator of Calcineurin 1 (Rcan1) Is Required for the Development of Pulmonary Eosinophilia in Allergic Inflammation in Mice

Autor: Nicholas A. Forward, Adam J. MacNeil, Tong-Jun Lin, Svetlana O. Carrigan, David W. Hoskin, Robert D. Junkins, Jason N. Berman, Jin-Tian Tang, Yongjun Yang

Publikováno v: The American Journal of Pathology. 179:1199-1210

The presence of eosinophils in the lung is often regarded as a defining feature of asthma. On allergen stimulation, numbers of eosinophils and their progenitors are increased in both the bone marrow and lungs. Eosinophil progenitors provide an ongoin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9d7810b3bae4defd48e743a3df4b04
https://doi.org/10.1016/j.ajpath.2011.05.022

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Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling

Autor: Nicholas A. Forward, David W. Hoskin, David M. Conrad, Carolyn D. Doucette, Melanie R. Power Coombs, Suzanne J. Furlong, Tong-Jun Lin

Publikováno v: Biochemical and Biophysical Research Communications. 407:801-806

Curcumin (diferulomethane) is the principal curcuminoid in the spice tumeric and a potent inhibitor of activation-induced T-lymphocyte proliferation; however, the molecular basis of this immunosuppressive effect has not been well studied. Here we sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a653d388dc106d47d1c187d17b309ec3
https://doi.org/10.1016/j.bbrc.2011.03.103

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Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice

Autor: Yongjun Yang, Nicholas A. Forward, Svetlana O. Carrigan, Brent Johnston, Thomas B. Issekutz, David W. Hoskin, Tong-Jun Lin

Publikováno v: Immunobiology. 214:211-222

Pseudomonas aeruginosa is a common cause of lung infection in immune compromised individuals. Studies in humans and mice have demonstrated that P. aeruginosa lung infection is associated with a predominant Th2 immune response, whereas Th1 responses a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b97e067503ea3c581af60a94a4cab6
https://doi.org/10.1016/j.imbio.2008.07.027

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Induction of CD4(+)CD25(+)Foxp3(-) regulatory T cells by Thy-1 stimulation of CD4(+) T cells

Autor: Melanie R. Power Coombs, David M. Conrad, David W. Hoskin, Nicholas A. Forward, Suzanne J. Furlong

Publikováno v: Immunology and cell biology. 90(2)

Thy-1 (CD90) on mouse T cells has been reported to have both T-cell activating and regulatory roles. In this study, we show that monoclonal antibody (mAb)-mediated crosslinking of Thy-1 on CD4(+) mouse T-cells-induced regulatory T (T(reg)) cells that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a753e7c299ee475dde0d73ef28b92e
https://pubmed.ncbi.nlm.nih.gov/21519344

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