Výsledky vyhledávání - "Nicholas A. Floreani"

The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics

Autor: Scott M. Turner, Lindsay S. Roberts, Marc K. Hellerstein, Nicholas A. Floreani, John C. Price, William E. Holmes, Mahalakshmi Shankaran, Cyrus F. Khambatta, Kelvin W. Li, Matthew D. Bruss, Marcy Dalidd

Publikováno v: Molecular & Cellular Proteomics : MCP

Calorie restriction (CR) promotes longevity. A prevalent mechanistic hypothesis explaining this effect suggests that protein degradation, including mitochondrial autophagy, is increased with CR, removing damaged proteins and improving cellular fitnes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33877cd08291ff80c002dd0ca8466b3
http://europepmc.org/articles/PMC3518108

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Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: Novel protective approach

Autor: Bryan Knipe, James Haorah, Nicholas A. Floreani, Yuri Persidsky

Publikováno v: Free Radical Biology and Medicine. 51:1601-1609

Oxidative damage of the endothelium disrupts the integrity of the blood-brain barrier (BBB). We have shown before that alcohol exposure increases the levels of reactive oxygen species (ROS; superoxide and hydroxyl radical) and nitric oxide (NO) in br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb9ced797f8dab8efa76b78c2d03d51
https://doi.org/10.1016/j.freeradbiomed.2011.06.020

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Alcohol-Induced Interactive Phosphorylation of Src and Toll-like Receptor Regulates the Secretion of Inflammatory Mediators by Human Astrocytes

Autor: Nicholas A. Floreani, James Haorah, Yuri Persidsky, Travis J. Rump, P. M. Abdul Muneer, Michael R. Brodie, Brenda Morsey, Saleena Alikunju

Publikováno v: Journal of Neuroimmune Pharmacology. 5:533-545

Secretion of pro-inflammatory molecules by astrocytes after alcohol treatment was shown to be associated with neuroinflammation. We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a00f79adc31277c9bc8fcb10553c9b
https://doi.org/10.1007/s11481-010-9213-z

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Measurement of human plasma proteome dynamics with (2)H(2)O and liquid chromatography tandem mass spectrometry

Autor: Nicholas A. Floreani, William E. Holmes, John C. Price, Kelvin Li, Scott M. Turner, Marc K. Hellerstein, Richard A. Neese

Publikováno v: Analytical biochemistry. 420(1)

Dysfunction of protein turnover is a feature of many human diseases, and proteins are substrates in important biological processes. Currently, no method exists for the measurement of global protein turnover (i.e., proteome dynamics) that can be appli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4761f100c08f695c8487739ee111ba62
https://pubmed.ncbi.nlm.nih.gov/21964502

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Mechanism of alcohol-induced oxidative stress and neuronal injury

Autor: Brenda Morsey, James Haorah, Yuri Persidsky, Nicholas A. Floreani, Servio H. Ramirez, Santhi Gorantla

Publikováno v: Free radical biologymedicine. 45(11)

Neuro-cognitive deficits, neuronal injury, and neurodegeneration are well documented in alcoholics, yet the underlying mechanisms remain elusive. Oxidative damage of mitochondria and cellular proteins intertwines with the progression of neuroinflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a846069f20aae51b40ae3748ef331ecd
https://pubmed.ncbi.nlm.nih.gov/18845238

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