Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Nicholas A. Fletcher"'
Autor:
Michael Agrez, Christopher Chandler, Kristofer J. Thurecht, Nicholas L. Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Benjamin Blyth, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew M. Hall, Hayley Gooding, Laura Gallagher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Cancers and autoimmune diseases commonly co-exist and immune checkpoint inhibitor therapy (ICI) exacerbates autoimmune pathologies. We recently described a lipidic peptide, designated IK14004, that promotes expansion of immunosuppressive T r
Externí odkaz:
https://doaj.org/article/e0f0af9605974d5ea5748b35c3c11dc8
Autor:
Xinying Jia, Yanni K.-Y. Chin, Alan H. Zhang, Theo Crawford, Yifei Zhu, Nicholas L. Fletcher, Zihan Zhou, Brett R. Hamilton, Martin Stroet, Kristofer J. Thurecht, Mehdi Mobli
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Head-to-tail macrocyclization of proteins and peptides can increase their structural stability, however, potential polymerization can lead to reduced yields. Here, the authors report the engineering of self-cyclizing ‘autocyclase’ proteins to gen
Externí odkaz:
https://doaj.org/article/e22b7329d2fa42c78900ee527f8a1241
Autor:
Mei-Chun Yeh, Brian W. C. Tse, Nicholas L. Fletcher, Zachary H. Houston, Maria Lund, Marianna Volpert, Chelsea Stewart, Kamil A. Sokolowski, Varinder Jeet, Kristofer J. Thurecht, Douglas H. Campbell, Bradley J. Walsh, Colleen C. Nelson, Pamela J. Russell
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Purpose Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth,
Externí odkaz:
https://doaj.org/article/2ef2c8e3d8664d7a8617ef5010ba309f
Autor:
Zachary H. Houston, Jens Bunt, Kok-Siong Chen, Simon Puttick, Christopher B. Howard, Nicholas L. Fletcher, Adrian V. Fuchs, Jiwei Cui, Yi Ju, Gary Cowin, Xin Song, Andrew W. Boyd, Stephen M. Mahler, Linda J. Richards, Frank Caruso, Kristofer J. Thurecht
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 727-738 (2020)
Externí odkaz:
https://doaj.org/article/3fb1a902064e45d0828820d915363b4e
Autor:
Nicholas K. Fletcher, Pelayo Acevedo, Jeremy S. Herman, Joana Paupério, Paulo C. Alves, Jeremy B. Searle
Publikováno v:
Ecology and Evolution, Vol 9, Iss 24, Pp 14101-14113 (2019)
Abstract Understanding the factors that contribute to the generation of reproductively isolated forms is a fundamental goal of evolutionary biology. Cryptic species are an especially interesting challenge to study in this context since they lack obvi
Externí odkaz:
https://doaj.org/article/b475c793783b41868316180b878818ba
Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma
Autor:
Taskeen Iqbal Janjua, Yuxue Cao, Aria Ahmed-Cox, Aun Raza, Md Moniruzzaman, Dewan Taslima Akhter, Nicholas L. Fletcher, Maria Kavallaris, Kristofer J. Thurecht, Amirali Popat
Publikováno v:
Journal of Controlled Release. 357:161-174
Autor:
Nora P. O’Neill, Andrew Z. Mo, Patricia E. Miller, Michael P. Glotzbecker, Ying Li, Nicholas D. Fletcher, Vidyadhar V. Upasani, Anthony I. Riccio, David Spence, Sumeet Garg, Walter Krengel, Craig Birch, Daniel J. Hedequist
Publikováno v:
Journal of Pediatric Orthopaedics. 43:273-277
Autor:
Saikat Ghosh, Nicholas L. Fletcher, Pie Huda, Zachary H. Houston, Christopher B. Howard, Maria E. Lund, Yanling Lu, Douglas H. Campbell, Bradley J. Walsh, Kristofer J. Thurecht
Publikováno v:
Molecular Pharmaceutics. 20:1549-1563
Autor:
Karishma T. Mody, Bing Zhang, Xun Li, Nicholas L. Fletcher, Dewan T. Akhter, Sandy Jarrett, Jun Zhang, Chengzhong Yu, Kristofer J. Thurecht, Timothy J. Mahony, Neena Mitter
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
Development of veterinary subunit vaccines comes with a spectrum of challenges, such as the choice of adjuvant, antigen delivery vehicle, and optimization of dosing strategy. Over the years, our laboratory has largely focused on investigating silica
Externí odkaz:
https://doaj.org/article/0272e8159f11403db17d9bcafb772e35
Autor:
K. Aaron Shaw, Hilary Harris, Numera Sachwani, Tracy Ruska, Joshua S. Murphy, Nicholas D. Fletcher
Publikováno v:
Spine Deformity. 11:671-676