Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nicholas A. Dawson"'
Autor:
Maya C. Poffenberger, Jennifer L. Bishop, Ryan J. Blackler, Kevin G. Haworth, Steven Booth, Shalla Hanson, Jeff R. Proctor, I-Ting Shao, Nichole K. Escalante, Dayananda Siddappa, Joel Smith, Gursev Anmole, Saki Konomura, Nicholas A. Dawson, Sifa Arrafi, Desmond Lau, Gerry Rowse, Rupert H. Davies, Thomas Spreter von Kreudenstein
Publikováno v:
Cancer Research. 83:2935-2935
IL-12 is a pleiotropic cytokine that potently stimulates anti-tumor cytotoxic T and NK cell mediated immunity. Recombinant IL-12 reduces tumor growth in multiple mouse models, but its therapeutic application has been limited by severe toxicities. Pro
Autor:
Jenna K. Currier, Nicholas J. Dawson, Luke Horsburgh, Carolyn E. A. Cooper, Adam D. Slater, Sarah A. Brokus, Randall D. Wade, Aaron A. Best, Michael J. Pikaart, Brent P. Krueger
Publikováno v:
The FASEB Journal. 36
Autor:
Nicholas W. Dawson, Joseph H. Hammer
Publikováno v:
Psychology of Men & Masculinities. 21:430-440
Publikováno v:
Bio Protoc
Regulatory T cells (Tregs) suppress immune responses via a variety of mechanisms and can be used as a cellular therapy to induce tolerance. The function of Tregs is commonly assessed in vitro using assays that measure suppression of effector T cell p
Autor:
Anne M. Pesenacker, Raewyn Broady, Megan K. Levings, Nicholas A.J. Dawson, Laura Cook, Avery J. Lam, Romy E. Hoeppli
Publikováno v:
European Journal of Immunology. 48:1415-1419
We optimized a method to detect FOXP3 by mass cytometry and compared the resulting data to conventional flow cytometry. We also demonstrated the utility of the protocol to profile antigen-specific Tregs from whole blood, or Tregs from tissues such as
Autor:
Megan K. Levings, Nicholas A.J. Dawson
Publikováno v:
Translational Research. 187:53-58
Cellular therapy with T-regulatory cells (Tregs) is a promising strategy to control immune responses and restore immune tolerance in a variety of immune-mediated diseases, such as transplant rejection and autoimmunity. Multiple clinical trials are cu
Autor:
Jana Gillies, Qing Huang, Isaac Rosado-Sánchez, Emma McIver, Paul C. Orban, Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Grace Sun, Vivian C.W. Fung, Majid Mojibian, German E. Novakovsky
Publikováno v:
Science translational medicine. 12(557)
Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors (CARs) are a potent immunosuppressive cellular therapy in multiple disease models and could overcome shortcomings of polyclonal Treg therapy. CAR therapy was initi
Autor:
Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Vivian C.W. Fung, German E. Novakovsky, Emma McIver, Majid Mojibian, Qing Huang, Grace Sun, Paul C. Orban, Jana Gillies, Isaac Rosado-Sánchez
SummaryAntigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptor (CARs) are a potent immunosuppressive cellular therapy in multiple disease models. To date the majority of CAR Treg studies employed second generation CARs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c0cd89dea68b3e90cc07b5f8030a8f
Autor:
Jonathan W. Bush, Jana Gillies, Madeleine Speck, Qing Huang, Megan K. Levings, Romy E. Hoeppli, Nicholas A.J. Dawson, Paul C. Orban, Caroline Lamarche, Emma McIver, Peter Bergqvist, Vivian C.W. Fung, Majid Mojibian
Publikováno v:
JCI Insight.
Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple disease models. As synthetic receptors, CARs carry the risk of
Publikováno v:
American Journal of Transplantation. 16:743-750
Obesity is often associated with the development of adipose tissue (AT) inflammation, resulting in metabolic dysfunction and an increased risk for developing type 2 diabetes. It is also associated with multiple chronic diseases, including cardiovascu