Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Nicholas A. Crump"'
Autor:
Pauline Schneider, Nicholas T. Crump, Susan T.C.J.M. Arentsen-Peters, Alastair L. Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Anja de Jong, Stefan Nierkens, Bianca Koopmans, Thomas A. Milne, Rob Pieters, Ronald W. Stam
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract In KMT2A-rearranged acute lymphoblastic leukemia (ALL), an aggressive malignancy, oncogenic KMT2A-fusion proteins inappropriately recruit DOT1L to promote leukemogenesis, highlighting DOT1L as an attractive therapeutic target. Unfortunately,
Externí odkaz:
https://doaj.org/article/66866a3dae3648df84fc292dc2646b8d
Autor:
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly und
Externí odkaz:
https://doaj.org/article/a2a886ce9d15408388b2e940336664d3
Autor:
Rebecca Ling, Thomas Jackson, Natalina Elliott, Joe Cross, Siobhan Rice, Rebecca Howitt, Alastair Smith, Joe Harman, Nicholas T Crump, Guanlin Wang, Deena Iskander, Supat Thongjuea, Philip Ancliff, Beth Psaila, Irene Roberts, Thomas Milne, Anindita Roy
Publikováno v:
HemaSphere, Vol 7, p e5649016 (2023)
Externí odkaz:
https://doaj.org/article/1a70baf48b1c4f12bacb34bdd6ceaaeb
Autor:
Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicat
Externí odkaz:
https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396
Autor:
Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O. J. Davies, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of BRD4 and Mediator in regulating enhancer-promoter interactions is poorly understood. Here the authors find that treatment with BET inhibitors or pharmacological degradation of BRD4 disrupts transcription while having very little effect on
Externí odkaz:
https://doaj.org/article/8fdcc190846d423ba9cdaa4d7f3a1b96
Autor:
Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in
Externí odkaz:
https://doaj.org/article/e4a9cce559524c16a138443251705752
Autor:
Pauline Schneider, Susan T.C.J.M. Arentsen-Peters, Nicholas T. Crump, Alastair Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Kirsten S. Vrenken, Dedeke rockx-Brouwer, Ziqin Tang, Wilbert P. Vermeij, Anja De Jong, Bianca Koopmans, M.Emmy M. Dolman, Thomas A. Milne, Rob Pieters, Ronald W. Stam
Publikováno v:
Blood. 140:8760-8761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::566ffbcd36b06fd75e813bba4b97afd6
https://doi.org/10.1182/blood-2022-166310
https://doi.org/10.1182/blood-2022-166310
Autor:
Nicholas T. Crump, Alastair Smith, Laura Godfrey, Nicole Jackson, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Thomas A. Milne
SummaryAberrant enhancer activation has been identified as a key mechanism driving oncogene expression in many cancers. Here we use TOPmentation (Transcription factor-OPtimized ChIPmentation) to probe enhancer usage in primary MLL-rearranged acute ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9be1a9880ea9bf4bea37b39ff662973
https://doi.org/10.1101/2022.05.27.493676
https://doi.org/10.1101/2022.05.27.493676
Autor:
Adam J. Mead, Jack Bartram, Natalina Elliott, Anindita Roy, Carryl Dryden, Christina Halsey, Siobhan Rice, Trisevgeni Crabb, Irene Roberts, Dilys Addy, Sorcha O’Byrne, Nicholas T. Crump, Nicholas Fordham, Gary Wright, Thomas Jackson, Dariusz Ladon, Thomas A. Milne, Philip Ancliff, Maria del Mar Lara Fanego, Sarah Inglott
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arises in utero: an MLL/KMT2A gene rearrangement (MLL-r). This is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f482cb0c7edcfa62aa38988a44fec1d
https://eprints.gla.ac.uk/258628/1/258628.pdf
https://eprints.gla.ac.uk/258628/1/258628.pdf
Autor:
Jim R. Hughes, Thomas A. Milne, Peng Hua, Doug Higgs, Lance Hentges, A. Marieke Oudelaar, James O.J. Davies, Nicholas T. Crump, Stephen Taylor, Mohsin Badat, Ron Schwessinger, Damien J. Downes, Lars L. P. Hanssen, Danuta M. Jeziorska
In higher eukaryotes, many genes are regulated by enhancers that are 104–106 base pairs (bp) away from the promoter. Enhancers contain transcription-factor-binding sites (which are typically around 7–22 bp), and physical contact between the promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab5bd6c8a32d66588d480180c494a7a
https://doi.org/10.1038/s41586-021-03639-4
https://doi.org/10.1038/s41586-021-03639-4