Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nicholas A. Courtney"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and
Externí odkaz:
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
Autor:
Zhenyong Wu, Lu Ma, Nicholas A. Courtney, Jie Zhu, Ane Landajuela, Yongli Zhang, Edwin R. Chapman, Erdem Karatekin
Publikováno v:
J Neurosci
Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release, composed of a single-pass transmembrane domain linked to two C2 domains (C2A and C2B) that bind calcium, acidic lipids, and SNARE proteins that dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5996c790fc882ac8fd68430f94d89b
https://doi.org/10.1523/jneurosci.1385-21.2022
https://doi.org/10.1523/jneurosci.1385-21.2022
Autor:
William E. Carson, Stephen V. Liu, Michael A. Caligiuri, John C. Byrd, Susheela Tridandapani, Panos Savvides, Theodoros N. Teknos, Thomas Olencki, Bonnie Paul, Sarvani Uppati, Akaansha Ganju, Tiffany Noel, Gonzalo N. Olaverria Salavaggione, Kala Levine, Kyle Martin, Kallan Williams, Megan C. Duggan, Amanda R. Campbell, Melanie E. Davis, Xiaokui Mo, Nicholas B. Courtney, Lakhvir S. Atwal, Brooke Benner, Elizabeth L. McMichael
Supplemental Figure S1. Levels of serum cytokines in patients over the course of treatment. Serum levels of the cytokines IFN-γ (A), IP-10 (B), TNF-α (C) MIP-1α (D), MIP-1β (E), RANTES (F), GM CSF (G), and IL-8 (H) were measured at baseline and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8119893f10dcaa84d086ec6e94a7d410
https://doi.org/10.1158/1078-0432.22473654.v1
https://doi.org/10.1158/1078-0432.22473654.v1
Autor:
William E. Carson, Stephen V. Liu, Michael A. Caligiuri, John C. Byrd, Susheela Tridandapani, Panos Savvides, Theodoros N. Teknos, Thomas Olencki, Bonnie Paul, Sarvani Uppati, Akaansha Ganju, Tiffany Noel, Gonzalo N. Olaverria Salavaggione, Kala Levine, Kyle Martin, Kallan Williams, Megan C. Duggan, Amanda R. Campbell, Melanie E. Davis, Xiaokui Mo, Nicholas B. Courtney, Lakhvir S. Atwal, Brooke Benner, Elizabeth L. McMichael
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b64ca0fa43e0f3983071c3c1c40f659
https://doi.org/10.1158/1078-0432.22473657.v1
https://doi.org/10.1158/1078-0432.22473657.v1
Autor:
William E. Carson, Stephen V. Liu, Michael A. Caligiuri, John C. Byrd, Susheela Tridandapani, Panos Savvides, Theodoros N. Teknos, Thomas Olencki, Bonnie Paul, Sarvani Uppati, Akaansha Ganju, Tiffany Noel, Gonzalo N. Olaverria Salavaggione, Kala Levine, Kyle Martin, Kallan Williams, Megan C. Duggan, Amanda R. Campbell, Melanie E. Davis, Xiaokui Mo, Nicholas B. Courtney, Lakhvir S. Atwal, Brooke Benner, Elizabeth L. McMichael
Purpose:mAbs including cetuximab can induce antibody-dependent cellular cytotoxicity (ADCC) and cytokine production mediated via innate immune cells with the ability to recognize mAb-coated tumors. Preclinical modeling has shown that costimulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ffeabc0c1eb9b4a77c33bc87dcefcf
https://doi.org/10.1158/1078-0432.c.6528570
https://doi.org/10.1158/1078-0432.c.6528570
Autor:
William E. Carson, Stephen V. Liu, Michael A. Caligiuri, John C. Byrd, Susheela Tridandapani, Panos Savvides, Theodoros N. Teknos, Thomas Olencki, Bonnie Paul, Sarvani Uppati, Akaansha Ganju, Tiffany Noel, Gonzalo N. Olaverria Salavaggione, Kala Levine, Kyle Martin, Kallan Williams, Megan C. Duggan, Amanda R. Campbell, Melanie E. Davis, Xiaokui Mo, Nicholas B. Courtney, Lakhvir S. Atwal, Brooke Benner, Elizabeth L. McMichael
Supplementary Table 1. Toxicities; Supplementary Table 2. Patient characteristics and response evaluation; Supplementary Table 3. Patient Correlative Study Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5557c5dd079ea9de46f510ea6a57cb1e
https://doi.org/10.1158/1078-0432.22473651.v1
https://doi.org/10.1158/1078-0432.22473651.v1
Autor:
Elizabeth L. McMichael, Nicholas B. Courtney, Megan C. Duggan, Robert Wesolowski, Dionisia Quiroga, Sri Vidya Kondadasula, Lakhvir S. Atwal, Neela Bhave, Eric Luedke, Alena Cristina Jaime-Ramirez, Amanda R. Campbell, Xiaokui Mo, John C. Byrd, William E. Carson
Publikováno v:
OncoImmunology, Vol 6, Iss 5 (2017)
Natural killer (NK) cells are innate immune effector cells that play a crucial role in immune surveillance and the destruction of cancer cells. NK cells express a low-affinity receptor for the Fc or constant region of immunoglobulin G (FcγRIIIa) and
Externí odkaz:
https://doaj.org/article/1f7632a522fa45dabefa4cefcfb62a4f
Autor:
William E. Carson, Isaac Rampersaud, Casey Ren, Vedat O. Yildiz, Charles E. Moritz, David Albertson, Steven Sun, Nicholas B. Courtney, Tiffany Noel, Arfaan Rampersaud, Nathaniel J Buteyn, Jonathan P. Butchar, Lorena P. Suarez-Kelly, Lianbo Yu, Megan C. Duggan, Susheela Tridandapani
Publikováno v:
ACS Appl Nano Mater
Background fluorescent nanodiamonds (FND) are nontoxic, infinitely photostable nanoparticles that emit near-infrared fluorescence and have a modifiable surface allowing for the generation of protein-FND conjugates. FND-mediated immune cell targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cbf9b77ee0aeb354ce10fb3f6a03be
https://doi.org/10.1021/acsanm.1c00256
https://doi.org/10.1021/acsanm.1c00256
Autor:
Erdem Karatekin, Nicholas A. Courtney, J. Zhu, Lu Ma, Yongli Zhang, Edwin R. Chapman, Zhenyong Wu
Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release. It is composed of a single-pass transmembrane domain linked to two tandem C2 domains (C2A and C2B) that bind calcium, acidic lipids, and SNARE pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250099e3e4a554c22237c165ba87fe0e
https://doi.org/10.1101/2021.07.05.451149
https://doi.org/10.1101/2021.07.05.451149
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs are constitutively active, so a major focus has been to identify fusion clamps that regulate their activity in synapses: the primary candidates are synaptotagmin (sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5626bd386a67b7cd684b84357a68fc
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1