Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nicholas A. Cilfone"'
Autor:
Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson, David S. DeLuca, Katherine C. Saunders, Dimitrios A. Pappas, Jeffrey D. Greenberg, Joel M. Kremer, Anthony M. Manning, Leona E. Ling, Ishan Capila
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders and non-responders
Externí odkaz:
https://doaj.org/article/3e82234a9ea54de3a35f19b6cf0f9913
Autor:
Joël R Pradines, Victor Farutin, Nicholas A Cilfone, Abouzar Ghavami, Elma Kurtagic, Jamey Guess, Anthony M Manning, Ishan Capila
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007684 (2020)
Identification of differentially expressed genes (DEGs) is well recognized to be variable across independent replications of genome-wide transcriptional studies. These are often employed to characterize disease state early in the process of discovery
Externí odkaz:
https://doaj.org/article/a5837b3677574c63bff19aa90422c1f7
Autor:
Jay D. Humphrey, Nicholas A. Cilfone, Mo Wang, Pei-Yu Chen, Bo Jiang, George Tellides, Arina Korneva, Arnar Geirsson, Jeffrey R. Gulcher, Lingfeng Qin, Guilin Wang, Sameet Mehta, Michael Simons, Thomas Chittenden, Yang Jiao, Alexander W. Caulk, Matthew R. Bersi, Guangxin Li, Zehua Chen, Chang-Shun He, Sameh Yousef, Xinran Liu, Sharvari Gujja
Publikováno v:
J Clin Invest
Smooth muscle cell (SMC) proliferation has been thought to limit the progression of thoracic aortic aneurysm and dissection (TAAD) because loss of medial cells associates with advanced disease. We investigated effects of SMC proliferation in the aort
Autor:
David S. DeLuca, Jan Hillson, Katherine C. Saunders, Jamey Guess, Joel M. Kremer, Patrick Halvey, Kristen Getchell, Carol J. Etzel, Anthony M. Manning, Robin Meccariello, Nicholas A. Cilfone, Victor Farutin, Ishan Capila, Kevin Mcconnell, Jay Duffner, Christopher M. Honan, Thomas Prod’homme, Bryan Gutierrez, Dimitrios A. Pappas, Leona E. Ling, Jeff Greenberg, Nur Sibel Gunay, Nathaniel Washburn, Ganlin Zhao
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-14 (2019)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders and non-responders in rheuma
Autor:
Carlos Fernández-Hernando, James E. Dahlman, Yang Jiao, Guangxin Li, Esther Lutgens, Jordan S. Pober, Michael Simons, Pascal J. H. Kusters, Binod Aryal, Daniel G. Anderson, Hongye Sun, Alberto Canfrán-Duque, Nicholas A. Cilfone, Jeffrey R. Gulcher, George Tellides, Sharvari Gujja, Pei-Yu Chen, Lele Sun, Rebecca Liu, Alfica Sehgal, Xinbo Zhang, Zheng Wang, Jose Malagon-Lopez, Martin A. Schwartz, Kevin J. Kauffman, Thomas Chittenden, Lingfeng Qin
Publikováno v:
Nature Metabolism, 1(9), 912-926. Springer Berlin
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal shear stress and endothelial lipid retention. A combination of these and, potentially, other factors leads to a chronic inflammatory response in the vessel wall
Autor:
Jeffrey R. Gulcher, Nicholas A. Cilfone, Carmen J. Booth, Heino Velazquez, Nicolas Ricard, Susan E. Quaggin, Michael Simons, Rizaldy P. Scott, Thomas Chittenden, Javier L. Baylon
Publikováno v:
The Journal of Experimental Medicine
Suppression of endothelial ERK1/1 pathways results in multi-organ failure, similar to what is observed in patients treated with anti-VEGF therapies.
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
The mechanism of maintaining vascular endothelial identity and integrity is largely unknown. In
Autor:
Leona E. Ling, James B. Streisand, Nicholas A. Cilfone, Anthony M. Manning, Renger G. Tiessen, Mattheus Paulus (Thijs) van Iersel, Jay Duffner, Darrell Nix, Santiago Arroyo, Lynn Markowitz, Jan Hillson, Tjerk Bosje
Publikováno v:
Clinical Pharmacology and Therapeutics
M281 is a fully human, anti-neonatal Fc receptor (FcRn) antibody that inhibits FcRn-mediated immunoglobulin G (IgG) recycling to decrease pathogenic IgG while preserving IgG production. A randomized, double-blind, placebo-controlled, first-in-human s
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68680 (2013)
Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) are key anti- and pro-inflammatory mediators elicited during the host immune response to Mycobacterium tuberculosis (Mtb). Understanding the opposing effects of these mediators is difficult
Externí odkaz:
https://doaj.org/article/3cb8e704931e46388d1a29b2ffb9222d
Autor:
Jennifer J. Linderman, Denise E. Kirschner, Nicholas A. Cilfone, Louis R. Joslyn, Caitlin Hult, Simeone Marino, Jess A. Millar, Joshua T. Mattila, Joseph M. Cicchese, Stephanie Evans, Timothy Wessler
Publikováno v:
Immunological Reviews. 285:147-167
Immune responses to pathogens are complex and not well understood in many diseases, and this is especially true for infections by persistent pathogens. One mechanism that allows for long-term control of infection while also preventing an over-zealous
Autor:
Richard Li, Omar Gamel, Jeffrey R. Gulcher, Sharvari Gujja, Daniel A. Lidar, Thomas Chittenden, Sweta R. Bajaj, Nicholas A. Cilfone
Publikováno v:
Patterns, Vol 2, Iss 6, Pp 100246-(2021)
Patterns
Patterns
Summary Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex molecular underpinnings of human disease from a genome-wide perspective. W