Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicholas A. Castello"'
Autor:
Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah, Frank M. LaFerla
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/a8f7f613f4364215aed3a6cbb63b15c4
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 107-117 (2014)
Synapse number is the best indicator of cognitive impairment In Alzheimer's disease (AD), yet the respective contributions of Aβ and tau, particularly human wild-type tau, to synapse loss remain undefined. Here, we sought to elucidate the Aβ-depend
Externí odkaz:
https://doaj.org/article/32c7a40f41554946b8166cf2a6707d13
Autor:
Jeremy W. Linsley, Drew A. Linsley, Josh Lamstein, Gennadi Ryan, Kevan Shah, Nicholas A. Castello, Viral Oza, Jaslin Kalra, Shijie Wang, Zachary Tokuno, Ashkan Javaherian, Thomas Serre, Steven Finkbeiner
Publikováno v:
Science Advances
Science Advances, vol 7, iss 50
Science Advances, vol 7, iss 50
Description
High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.
Cellular events underlying neurodegenerative disease may be captured by longitudinal live microsco
High-throughput microscopy has outpaced analysis; biomarker-optimized CNNs are a generalizable, fast, and interpretable solution.
Cellular events underlying neurodegenerative disease may be captured by longitudinal live microsco
Autor:
Jeremy W. Linsley, Shijie Wang, Viral Oza, Steven Finkbeiner, Zak Doric, Wiktoria Leks, Jay Mancini, Nicholas A. Castello, David Kokel, Ashkan Javaherian, Michelle Chan, Kevan Shah, Ken Nakamura, Dominik Haddad
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Cell death is a critical process that occurs normally in health and disease. However, its study is limited due to available technologies that only detect very late stages in the process or specific death mechanisms. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b02a539fa127a0e9d78757ad7a412f
https://escholarship.org/uc/item/7cs8x20m
https://escholarship.org/uc/item/7cs8x20m
Publikováno v:
Neuromethods ISBN: 9781071615881
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbe97191376231e0b938bcf75d29390
https://doi.org/10.1007/978-1-0716-1589-8_5
https://doi.org/10.1007/978-1-0716-1589-8_5
Autor:
Aaron D. Gitler, Nicholas J. Brandon, Korrie L. Mack, Hana M. Odeh, Thomas A. Ollerhead, Bo Lim Lee, Stephen J. Moss, Bradley Class, Ashkan Javaherian, James Shorter, John Dunlop, Alice Flynn Ford, Mari Aikio, Steven Finkbeiner, Heike J. Wobst, Ryan R. Cupo, Lauren E. Drake, Dean G. Brown, Ashmita Baral, Nicholas A. Castello, Edward M. Barbieri
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a033b9c4422f431aa9088ab9b0181b
https://doi.org/10.1101/2021.08.04.455154
https://doi.org/10.1101/2021.08.04.455154
Autor:
Nicholas A Castello, Michael H Nguyen, Jenny D Tran, David Cheng, Kim N Green, Frank M LaFerla
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91453 (2014)
Augmenting BDNF/TrkB signaling has been demonstrated to be a promising strategy for reversing cognitive deficits in preclinical models of Alzheimer disease (AD). Although these studies highlight the potential of targeting BDNF/TrkB signaling, this st
Externí odkaz:
https://doaj.org/article/c45d67a75fb14daa9a9fb95748c3b81f
Autor:
Jeremy W. Linsley, Ashkan Javaherian, Josh Lamstein, Viral Oza, Steven Finkbeiner, Gennadi Ryan, Zachary Tokuno, Drew Linsley, Shijie Wang, Thomas Serre, Kevan Shah, Jaslin Kalra, Nicholas A. Castello
Cell death is an essential process in biology that must be accounted for in live microscopy experiments. Nevertheless, cell death is difficult to detect without perturbing experiments with stains, dyes or biosensors that can bias experimental outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b99f9521d2fa22b89e646e6c84bcbaed
https://doi.org/10.1101/2020.08.04.237032
https://doi.org/10.1101/2020.08.04.237032
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e39566 (2012)
Brain-derived neurotrophic factor (BDNF) is a neurotrophin critically involved in cell survival, synaptic plasticity, and memory. BDNF has recently garnered significant attention as a potential therapeutic target for neurodegenerative diseases such a
Externí odkaz:
https://doaj.org/article/bb53bf904fbf4799bf2030be42e40b24
Autor:
Izumi V. Hinkson, Jae K. Ryu, Eva Czirr, Katerina Akassoglou, Nicholas A. Castello, Sasha N. Farina, Nadia P. Belichenko, John R. Cirrito, Markus Britschgi, Kira I. Mosher, Lulin Li, Tony Wyss-Coray, Bernat Baeza-Raja, Joseph M. Castellano, Frank M. Longo, Kurt M. Lucin
Publikováno v:
The Journal of Experimental Medicine
Czirr et al. report that microglia lacking complement receptor 3 display increased extracellular Aβ degrading activity and that targeting the receptor with a small molecule increases Aβ clearance in vivo, thus identifying a microglial receptor as a