Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Nicholas A Sinnott-Armstrong"'
Publikováno v:
Judgment and Decision Making, Vol 5, Pp 547-554 (2010)
As the study of moral judgments grows, it becomes imperative to compare results across studies in order to create unified theories within the field. These efforts are potentially undermined, however, by variations in wording used by different researc
Externí odkaz:
https://doaj.org/article/0cd2aea04d814b728e1306a5b71b667f
Autor:
Kristen E Wong, Jacqueline Fung, Andrea Lunardi, Kerry K. Brown, Pier Paolo Pandolfi, Andrew Ivanov, Yanbo Yin, Markus Reschke, Garrett T Wong, Nikolaos A. Patsopoulos, Robin E. Williamson, Ann E. Hickox, Sabina Signoretti, Kathleen S. Arnos, M. Charles Liberman, Ming Chen, Maura Bríd Cotter, Cynthia C. Morton, Nicholas A Sinnott-Armstrong, Tammy Kammin, Richard C Sallari, Benjamin Currall, Jun Shen, Nahid G. Robertson, Kathryn L. Penney, Cinthya J. Zepeda-Mendoza, Bradley J. Quade, Manolis Kellis, Alexander S. Banks
Publikováno v:
Human Molecular Genetics. 27:4194-4203
Great strides in gene discovery have been made using a multitude of methods to associate phenotypes with genetic variants, but there still remains a substantial gap between observed symptoms and identified genetic defects. Herein, we use the converge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81994d8447fdeb9d8f2e6038f4ffed0
https://doi.org/10.1093/hmg/ddy310
https://doi.org/10.1093/hmg/ddy310
Autor:
Morten Muhlig Nielsen, Tobias Madsen, Jakob Skou Pedersen, Torben F. Ørntoft, Michał P. Świtnicki, Malene Juul, Richard C Sallari, Asger Hobolth, Manolis Kellis, Nicholas A Sinnott-Armstrong, Henrik Hornshøj
Publikováno v:
npj Genomic Medicine, Vol 3, Iss 1, Pp 1-14 (2018)
Hornshøj, H, Nielsen, M M, Sinnott-Armstrong, N A, Świtnicki, M P, Juul, M, Madsen, T, Sallari, R, Kellis, M, Ørntoft, T, Hobolth, A & Pedersen, J S 2018, ' Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival ', npj Genomic Medicine, vol. 3, pp. 1 . https://doi.org/10.1038/s41525-017-0040-5
NPJ Genomic Medicine
Hornshøj, H, Nielsen, M M, Sinnott-Armstrong, N A, Świtnicki, M P, Juul, M, Madsen, T, Sallari, R, Kellis, M, Ørntoft, T, Hobolth, A & Pedersen, J S 2018, ' Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival ', npj Genomic Medicine, vol. 3, pp. 1 . https://doi.org/10.1038/s41525-017-0040-5
NPJ Genomic Medicine
Cancer develops by accumulation of somatic driver mutations, which impact cellular function. Mutations in non-coding regulatory regions can now be studied genome-wide and further characterized by correlation with gene expression and clinical outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d792becab13a20bb0d8d2954cac9ea3
http://link.springer.com/article/10.1038/s41525-017-0040-5
http://link.springer.com/article/10.1038/s41525-017-0040-5
Autor:
Aubhishek Zaman, Wenxue Tang, Collisson E, Jingeng Liu, Lei Sun, Snyder M, Yuanbo Cui, Han Xu, Wang J, Cao W, Pengju Lv, Lou Y, Xing Q, Pengli Han, Jiancheng Guo, Ming Yan, Trever G. Bivona, Sailani M, Chang J, Nicholas A Sinnott-Armstrong, Gundolf Schenk, Alan Hunter Shain, Jia-Yun Chen, Sean R. McCorkle, X B Sun, Fred G. Biddle, Gao Y, Hongya Guan, Hong-pyo Lee, Wesley Wu
Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bde219cea0153e564cdeecdd79c7184
Autor:
Anshul Kundaje, Georgi K. Marinov, Jan M. Skotheim, Nicholas A. Sinnott-Armstrong, William J. Greenleaf, Zohar Shipony, Matthew P. Swaffer
Publikováno v:
Nat Methods
Active regulatory elements in eukaryotes are typically characterized by an open, nucleosome-depleted chromatin structure; mapping areas of open chromatin has accordingly emerged as a widely used tool in the arsenal of modern functional genomics. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f250d52b466a26469f5f4d4e546c74a
https://pubmed.ncbi.nlm.nih.gov/32042188
https://pubmed.ncbi.nlm.nih.gov/32042188
Autor:
Rossanna C. Pezo, Trevor J. Pugh, Mark Dowar, David W. Cescon, Ken Kron, Jennifer Silvester, Tak W. Mak, Mathieu Lupien, Benjamin Haibe-Kains, Aislinn E. Treloar, S. Y. Cindy Yang, Philippe L. Bedard, Richard C Sallari, Parisa Mazrooei, Kinjal Desai, Kelsie L. Thu, Xue Wu, Nicholas A Sinnott-Armstrong, Swneke D. Bailey
Publikováno v:
Nature genetics
Sustained expression of the estrogen receptor-α (ESR1) drives two-thirds of breast cancer and defines the ESR1-positive subtype. ESR1 engages enhancers upon estrogen stimulation to establish an oncogenic expression program. Somatic copy number alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfd15af10ec905311dbe14152c627af
https://doi.org/10.1038/ng.3650
https://doi.org/10.1038/ng.3650
Autor:
Jun-Han Su, Xiaowei Zhuang, Alistair N. Boettiger, Bogdan Bintu, Seon Kinrot, Leslie J. Mateo, Nicholas A Sinnott-Armstrong, Kei Yamaya, Mirae Parker
Publikováno v:
Science. 362
Imaging chromatin spatial organization The genome is organized within the nucleus as three-dimensional domains that modulate DNA-templated processes. Bintu et al. used high-throughput Oligopaint labeling and imaging to observe chromatin dynamics insi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f334c16b7a82894d2427eb7f170ddc7
https://doi.org/10.1126/science.aau1783
https://doi.org/10.1126/science.aau1783
Autor:
Pcawg Drivers, Chris Sander, Todd A. Johnson, Jüri Reimand, Lina Wadi, Dimple Chakravarty, Claes Wadelius, Rory Johnson, Abel Gonzalez-Perez, Jing Zhang, Nicholas A Sinnott-Armstrong, Icgc, Abdullah Kahraman, Nicholas J. Haradhvala, Husen M. Umer, Priyanka Dhingra, Michael S. Lawrence, Inigo Martincorena, Ben Raphael, André Kahles, Chen Hong, Esther Rheinbay, Joana Carlevaro-Fita, Loris Mularoni, Tatsuhiko Tsunoda, Qianyun Guo, Andrés Arturo Lanzós Camaioni, Yosef E. Maruvka, Josh Stuart, Dong-Hoon Lee, Jakob Skou Pedersen, Jaegil Kim, Klev Diamanti, Nuno A. Fonseca, Julian M. Hess, Federico Abascal, Samir B. Amin, Kjong-Van Lehmann, Carl Herrmann, Ekta Khurana, Mark Gerstein, Mark A. Rubin, Mark P. Hamilton, Lars Feuerbach, Oriol Pich, Lincoln Stein, Keunchil Park, Keith A. Boroevich, Liis Uusküla-Reimand, Ciyue Shen, Lucas Lochovsky, David Tamborero, Gad Getz, Shimin Shuai, Randi Istrup Istrup Pedersen, Johanna Bertl, Lina Sieverling, Young-Wook Kim, Morten Muhlig Nielsen, Keren Isaev, Calvin Wing Yiu Chan, Asger Hobolth, Malene Juul, Eric Minwei Liu, Henrik Hornshøj, Jan Komorowski, Sushant Kumar, Nuria Lopez-Bigas, David A. Wheeler, Manolis Kellis, Peter J. Campbell, Radhakrishnan Sabarinathan, Grace Tiao, Gordon Saksena, Henrik Tobias Madsen
Publikováno v:
bioRxiv
pre
pre
Discovery of cancer drivers has traditionally focused on the identification of protein-coding genes. Here we present a comprehensive analysis of putative cancer driver mutations in both protein-coding and non-coding genomic regions across >2,500 whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaec91ebd7eaa8c5486f9e530572e585
https://doi.org/10.1101/237313
https://doi.org/10.1101/237313
Autor:
M. Ryan Corces, Alexandro E. Trevino, Emily G. Hamilton, Peyton G. Greenside, Nicholas A Sinnott-Armstrong, Sam Vesuna, Ansuman T. Satpathy, Adam J. Rubin, Kathleen S. Montine, Beijing Wu, Arwa Kathiria, Seung Woo Cho, Maxwell R. Mumbach, Ava C. Carter, Maya Kasowski, Lisa A. Orloff, Viviana I. Risca, Anshul Kundaje, Paul A. Khavari, Thomas J. Montine, William J. Greenleaf, Howard Y. Chang
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24465ee480a7f4aa6407b123b1a06d49
https://doi.org/10.1038/protex.2017.096
https://doi.org/10.1038/protex.2017.096
Autor:
Howard Y. Chang, Maxwell R. Mumbach, Anshul Kundaje, Maya Kasowski, Kathleen S. Montine, Viviana I. Risca, Beijing Wu, Ansuman T. Satpathy, Alexandro E. Trevino, M. Ryan Corces, Thomas J. Montine, Arwa Kathiria, Adam J. Rubin, Peyton Greenside, Paul A. Khavari, Emily G. Hamilton, William J. Greenleaf, Nicholas A Sinnott-Armstrong, Sam Vesuna, Ava C. Carter, Lisa A. Orloff, Seung Woo Cho
Publikováno v:
Nature methods. 14(10)
We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility profiling that works across multiple applications with substantial improvement of signal-to-background ratio and information content. The Omni-ATAC protocol enables chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5aa81fcd0a226ca0254156920fa514
https://pubmed.ncbi.nlm.nih.gov/28846090
https://pubmed.ncbi.nlm.nih.gov/28846090