Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Nicholas A Shackel"'
Autor:
Christine Yee, Nathan M Main, Alexandra Terry, Igor Stevanovski, Annette Maczurek, Alison J Morgan, Sarah Calabro, Alison J Potter, Tina L Iemma, David G Bowen, Golo Ahlenstiel, Fiona J Warner, Geoffrey W McCaughan, Susan V McLennan, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0215557 (2019)
BackgroundChronic inflammation is the driver of liver injury and results in progressive fibrosis and eventual cirrhosis with consequences including both liver failure and liver cancer. We have previously described increased expression of the highly m
Externí odkaz:
https://doaj.org/article/d0940ab7fa584a72b7bc28e44329defd
Autor:
Magdalena A Budzinska, Thomas Tu, William M H d'Avigdor, Geoffrey W McCaughan, Fabio Luciani, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162586 (2016)
In hepatocellular carcinoma (HCC), somatic genome-wide DNA mutations are numerous, universal and heterogeneous. Some of these somatic mutations are drivers of the malignant process but the vast majority are passenger mutations. These passenger mutati
Externí odkaz:
https://doaj.org/article/40cffdb6863b47efb94ccf60efa57b74
Autor:
Sarah R Calabro, Annette E Maczurek, Alison J Morgan, Thomas Tu, Victoria W Wen, Christine Yee, Auvro Mridha, Maggie Lee, William d'Avigdor, Stephen A Locarnini, Geoffrey W McCaughan, Fiona J Warner, Susan V McLennan, Nicholas A Shackel
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e90571 (2014)
The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulat
Externí odkaz:
https://doaj.org/article/5fb65a4f64194cb481221ea58bfb0859
Autor:
Helen Vidot, Nicholas A. Shackel
Publikováno v:
Current Hepatology Reports. 20:53-60
Malnutrition is common in patients with decompensated cirrhosis and portal hypertension and is associated with impaired health-related quality of life and reduced survival. This review aims to explore the outcomes of specific nutritional intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2ad466c699035450a2406093531706b
https://doi.org/10.1007/s11901-021-00561-1
https://doi.org/10.1007/s11901-021-00561-1
Autor:
Geoffrey W. McCaughan, David G. Bowen, Varan Perananthan, Simone I. Strasser, Ken Liu, Nicholas A. Shackel, Helen Vidot, Avik Majumdar, Edwin Arthur Shores
Publikováno v:
GastroHep. 3:50-57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e283d5b026a9481069f4ee2c1f721a14
https://doi.org/10.1002/ygh2.439
https://doi.org/10.1002/ygh2.439
Publikováno v:
Clinical Science
Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the renin–angiotensin system (RAS). The classical RAS is driven by its key enzyme ACE and is pivotal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d066d22b96bd76032f915063937e1e0
https://doi.org/10.1042/cs20201268
https://doi.org/10.1042/cs20201268
Autor:
Chandana B Herath, Harinda Rajapaksha, Peter W Angus, Lakmie S Gunarathne, Nicholas A. Shackel
The most common cause of morbidity and mortality in cirrhotic patients is portal hypertension and bleeding from gastroesophageal varices.Portal hypertension is initiated by increased intrahepatic vascular resistance and a hyperdynamic circulatory sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93f2b4a59223203bb4d1965c69e73efe
https://doi.org/10.9734/bpi/hmms/v13/9900d
https://doi.org/10.9734/bpi/hmms/v13/9900d
Autor:
Marion G. Peters, Joe Sasadeusz, Seng Lee Lim, Andrew Grigg, Peter Hughes, Monica A. Slavin, Geoff McColl, Joseph Doyle, James A Rickard, Kumar Visvanathan, Sue-Anne McLachlan, Peter De Cruz, Michaela Lucas, Vijaya Sundararajan, Nicholas A. Shackel, Robert G. Gish, Alexander J. Thompson
Publikováno v:
Clinics in Liver Disease. 23:493-509
Current recommendations concerning hepatitis C virus (HBV) reactivation are limited, with nearly all guidelines focused on its occurrence in patients with hematological malignancies or some solid tumors, who are treated with immunosuppressive therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef90b8362e9563a720332e47c33ff40
https://doi.org/10.1016/j.cld.2019.04.010
https://doi.org/10.1016/j.cld.2019.04.010
Autor:
Geoffrey C. Farrell, W. d’Avigdor, Susan V. McLennan, M Stapelberg, M. Lee, Geoffrey W. McCaughan, Thomas Tu, Magdalena A. Budzinska, James G. Kench, Nicholas A. Shackel, R Lam, Jacob George
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Despite advances in antiviral therapy, molecular drivers of Hepatitis C Virus (HCV)-related liver disease remain poorly characterised. Chronic infection with HCV genotypes (1 and 3) differ in presentation of liver steatosis and virological response t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5141aa3e4088ee8f7c2e63c1830ec9d8
http://link.springer.com/article/10.1038/s41598-019-46664-0
http://link.springer.com/article/10.1038/s41598-019-46664-0
Autor:
Jennifer Philip, John S Lubel, Miriam T. Levy, Simone I. Strasser, Nicholas A. Shackel, Stephen Clarke, Alexander Jv Thompson, Darrell H. G. Crawford, Stuart K. Roberts, Mark D Goodwin
Publikováno v:
The Medical journal of Australia. 214(10)
Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths both globally and in Australia. Surveillance for HCC in at-risk populations allows diagnosis at an early stage, when potentially curable. However, most Australians diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4096344399d767e739179b9d516d8b60
https://pubmed.ncbi.nlm.nih.gov/34510464
https://pubmed.ncbi.nlm.nih.gov/34510464