Výsledky vyhledávání - "Nicholas A Saunders"

Akademický článek

Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis.

Autor: Liliana Endo-Munoz, Na Cai, Andrew Cumming, Rebecca Macklin, Lilia Merida de Long, Eleni Topkas, Pamela Mukhopadhyay, Michelle Hill, Nicholas A Saunders

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133592 (2015)

Pulmonary metastasis is the major untreatable complication of osteosarcoma (OS) resulting in 10-20% long-term survival. The factors and pathways regulating these processes remain unclear, yet their identification is crucial in order to find new thera

Externí odkaz: https://doaj.org/article/659d63ddc58c40a2a08f5b9ea856210c

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Akademický článek

SIRPα Suppresses Response to Therapeutic Antibodies by Nurse Like Cells From Chronic Lymphocytic Leukemia Patients

Autor: Yu-Chen Enya Chen, Melinda Burgess, Sally Mapp, Peter Mollee, Devinder Gill, Antje Blumenthal, Nicholas A. Saunders

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Targeted antibody therapies improve outcomes for chronic lymphocytic leukemia (CLL) patients. However, resistance often develops. We have previously shown that resistance to therapeutic antibodies, by monocyte derived macrophages (referred to as nurs

Externí odkaz: https://doaj.org/article/b9578f6fa5824a12a011388f3633dbd1

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Resolution of Melanoma to Programmed Death-1 Blockade but Simultaneous Rapid Progression of Concomitant Chronic Lymphocytic Leukemia

Autor: Melinda Burgess, Colm Keane, Josh WD Tobin, Soi C. Law, Alison Griffin, Devinder Gill, Adam D. Ewing, Victoria Atkinson, Peter Mollee, Muhammed B. Sabdia, Nicholas A. Saunders, Maher K. Gandhi

Publikováno v: Acta Haematologica. 146:166-171

Here, we present a novel case of a patient with chronic lymphocytic leukemia (CLL) who received CTLA-4 and then PD-1 immune-checkpoint blockade (ICB) as treatment for concomitant metastatic melanoma. Whereas the metastatic melanoma was responsive to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::236388909d6060e3de27b01caed13bbf
https://doi.org/10.1159/000527631

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Data from A Novel E2F/Sphingosine Kinase 1 Axis Regulates Anthracycline Response in Squamous Cell Carcinoma

Autor: Nicholas A. Saunders, Liliana Endo-Munoz, Fiona Simpson, Pamela Mukhopadhyay, Marcin Dzienis, Ana Cristina Vargas, Samuel Boros, Eleni Topkas, Orla M. Gannon, Lilia Merida de Long, Mehlika Hazar-Rethinam

Purpose: Head and neck squamous cell carcinomas (HNSCC) are frequently drug resistant and have a mortality rate of 45%. We have previously shown that E2F7 may contribute to drug resistance in SCC cells. However, the mechanism and pathways involved re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0212cd25a1412b06361d4a95df861e97
https://doi.org/10.1158/1078-0432.c.6524655

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Data from Cisplatin Treatment Induces a Transient Increase in Tumorigenic Potential Associated with High Interleukin-6 Expression in Head and Neck Squamous Cell Carcinoma

Autor: Nicholas A. Saunders, Ibtissam A. Jabbar, Paul J. Leo, Gethin P. Thomas, Alexander D. Guminski, Kim J. Poth

Head and neck squamous cell carcinoma (HNSCC) is characterized by the 5-year survival rate of ∼50%. Despite aggressive surgical, radiation, and chemotherapeutic interventions, 30% to 40% of patients die from the development of recurrent or dissemin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440bc375e987e1a165431a507720f0ef
https://doi.org/10.1158/1535-7163.c.6532055.v1

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Supplementary Figure 2 from Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation

Autor: Nicholas A. Saunders, Mehlika Hazar-Rethinam, Liliana Endo-Munoz, Lilia Merida de Long, Orla M. Gannon

PDF file - 1290K, Supplementary Figure 2. siRNA against EZH2 does not induce apoptosis. Detroit 562 cells and primary keratinocytes (HEK) were treated with siRNA against EZH2 for 48 hours or 96 hours and stained with Annexin V/7 aminoactinomycin D an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dfb1520526312c749c5ca7bd29abc2
https://doi.org/10.1158/1078-0432.22454493.v1

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