Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicholas A Popp"'
Autor:
John C. Rose, Nicholas A. Popp, Christopher D. Richardson, Jason J. Stephany, Julie Mathieu, Cindy T. Wei, Jacob E. Corn, Dustin J. Maly, Douglas M. Fowler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Numerous strategies exist to limit the off-target activity of CRISPR-Cas9 nucleases. Here the authors co-administer truncated gRNAs that block both Cas9 and high-fidelity Cas9 variants from cleaving at off-target sites.
Externí odkaz:
https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524
Autor:
Cindy T. Wei, Nicholas A. Popp, Omri Peleg, Rachel L. Powell, Elhanan Borenstein, Dustin J. Maly, Douglas M. Fowler
Publikováno v:
Nature Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f9b315b203b1dd47c6152f192f1d226
https://doi.org/10.1038/s41589-023-01278-6
https://doi.org/10.1038/s41589-023-01278-6
Autor:
Nicholas A Popp, Rachel L Powell, Brendan Zapp, Kerry Lannert, Jill M. Johnsen, Douglas M Fowler
Publikováno v:
Blood. 140:5582-5583
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a97cf357a83d0cd4af45ee29eaa3c00
https://doi.org/10.1182/blood-2022-164996
https://doi.org/10.1182/blood-2022-164996
Autor:
Julie Mathieu, Dustin J. Maly, Jacob E. Corn, Cindy T. Wei, Christopher D. Richardson, Nicholas A. Popp, Douglas M. Fowler, John C. Rose, Jason J. Stephany
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, 11 (1)
Nature Communications
Nature Communications, 11 (1)
Nature Communications
CRISPR-Cas9 nucleases are powerful genome engineering tools, but unwanted cleavage at off-target and previously edited sites remains a major concern. Numerous strategies to reduce unwanted cleavage have been devised, but all are imperfect. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be21945dce57cba53b0cd8e7294fb562
https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524
https://doaj.org/article/32953ad84ae148f1a96180fcc11e3524
Autor:
Taiji Mizoguchi, Bryan T MacDonald, Bidur Bhandary, Nicholas R Popp, Dylan Laprise, Alessandro Arduini, Daniel Lai, Qiuyu M Zhu, Yi Xing, Virendar K Kaushik, Sekar Kathiresan, Patrick T Ellinor
Publikováno v:
Circulation. 144
Background: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 is protective for atherosclerosis. ADAMTS7 (a disintegrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb9198568b6acf074ecdb460637fc06
https://doi.org/10.1161/circ.144.suppl_1.12121
https://doi.org/10.1161/circ.144.suppl_1.12121
Autor:
Shida Chen, Defen Shen, Nicholas A. Popp, Alexander J. Ogilvy, Jingsheng Tuo, Mones Abu-Asab, Ting Xie, Chi-Chao Chan
Publikováno v:
Journal of Ophthalmology, Vol 2015 (2015)
Purpose. To investigate how multipotent retinal stem cells (RSCs) isolated from mice respond to the proinflammatory signaling molecules, IL-1β, IL-18, and IL-17A. Materials and Methods. RSCs were cultured in a specific culture medium and were treate
Externí odkaz:
https://doaj.org/article/c93a33bba0cb4fe3bae59b497d050ba0
Autor:
Nicholas R Popp, Patrick T. Ellinor, Qiuyu Martin Zhu, Yi Xing, Alessandro Arduini, Taiji Mizoguchi, Daniel Lai, Dylan Laprise, Virendar K. Kaushik, Sekar Kathiresan, Bryan T. MacDonald, Bidur Bhandary
Publikováno v:
Circ Res
Rationale: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3955d330c41dd2893ed411cbafb6269e
https://europepmc.org/articles/PMC8349873/
https://europepmc.org/articles/PMC8349873/
Autor:
Dylan Laprise, Virendar K. Kaushik, Steven A. Carr, Karl R. Clauser, Kayla Bendinelli, Bryan T. MacDonald, Charles C Mundorff, Yi Xing, Hasmik Keshishian, Alessandro Arduini, Daniel Lai, Bidur Bhandary, Nicholas R Popp, Patrick T. Ellinor, Harrison Specht, Nadine H. Elowe
Publikováno v:
Molecular & Cellular Proteomics. 21:100223
Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs 7) are associated with protection for coronary artery disease (CAD). ADAMTS7 catalytic inhibition has been proposed as a therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2338f2edcdd9eb631849088510d94b3
https://doi.org/10.1016/j.mcpro.2022.100223
https://doi.org/10.1016/j.mcpro.2022.100223
Autor:
Nicholas A Popp, Alexandra E. Grier, Unja Martin, Kyle Jacoby, Julia G. Yang, Stephen Burleigh, Michael C. Jensen, Andrew M. Scharenberg, Michelle C Krutein, Kamila S. Gwiazda, Jaya Sahni, David J. Rawlings, Iram F. Khan
Many future therapeutic applications of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 and related RNA-guided nucleases are likely to require their use to promote gene targeting, thus necessitating development of methods that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980de1f2fa3c70eba0b91ff7585a9386
https://europepmc.org/articles/PMC5113096/
https://europepmc.org/articles/PMC5113096/