Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nicholas A Bayley"'
Autor:
Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
Publikováno v:
eLife, Vol 8 (2019)
GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoprotei
Externí odkaz:
https://doaj.org/article/c9e3de5bd1f74f16b0b5035d702b97d3
Autor:
Elizabeth G. Fernandez, Wilson X. Mai, Kai Song, Nicholas A. Bayley, Jiyoon Kim, Henan Zhu, Marissa Pioso, Pauline Young, Cassidy L. Andrasz, Dimitri Cadet, Linda M. Liau, Gang Li, William H. Yong, Fausto J. Rodriguez, Scott J. Dixon, Andrew J. Souers, Jingyi Jessica Li, Thomas G. Graeber, Timothy F. Cloughesy, David A. Nathanson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynam
Externí odkaz:
https://doaj.org/article/448c7d25de1847ae879892038cc09dad
Autor:
Junhui Hu, Ping Tan, Moe Ishihara, Nicholas A. Bayley, Shiruyeh Schokrpur, Jeremy G. Reynoso, Yangjun Zhang, Raymond J. Lim, Camelia Dumitras, Lu Yang, Steven M. Dubinett, Parmjit S. Jat, Jacques Van Snick, Jiaoti Huang, Arnold I. Chin, Robert M. Prins, Thomas G. Graeber, Hua Xu, Lily Wu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact
Externí odkaz:
https://doaj.org/article/7fbb896806994806aeb3daa83568734f
Autor:
Jenna K. Minami, Danielle Morrow, Nicholas A. Bayley, Elizabeth G. Fernandez, Jennifer J. Salinas, Christopher Tse, Henan Zhu, Baolong Su, Rhea Plawat, Anthony Jones, Alessandro Sammarco, Linda M. Liau, Thomas G. Graeber, Kevin J. Williams, Timothy F. Cloughesy, Scott J. Dixon, Steven J. Bensinger, David A. Nathanson
Publikováno v:
Cancer Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a444e1faec9ea0f7bfdb27e1c0ee72b
https://doi.org/10.1016/j.ccell.2023.05.001
https://doi.org/10.1016/j.ccell.2023.05.001
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
This file contains supplemental figures: Supplemental Figure S1. HK2 ASOs selectively inhibit the proliferation of HK1-HK2+ MM cells. Supplemental Figure S2. The HK2-ASO1/DPI/PER combination causes synthetic lethality in HK1-HK2+ cells. Supplemental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e269c3863ca8a09ffd8d38c0cef8040b
https://doi.org/10.1158/0008-5472.22418646
https://doi.org/10.1158/0008-5472.22418646
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
This file contains supplemental materials and methods used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0bcbb63e2460070b4a06cf04376e3b
https://doi.org/10.1158/0008-5472.22418643
https://doi.org/10.1158/0008-5472.22418643
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
Metabolite measurement in OPM2 cells treated with HK2-ASO1, DPI, MET, PER, and their combinations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fba10c6f92b5e3c3c4d19929ad225f5
https://doi.org/10.1158/0008-5472.22418640
https://doi.org/10.1158/0008-5472.22418640
Autor:
Harvey R. Herschman, Sherie L. Morrison, A. Robert MacLeod, Youngsoo Kim, Sarah M. Larson, John M. Timmerman, Joshua P. Sasine, Alex Vasuthasawat, Reiko E. Yamada, Nicholas A. Bayley, Daniel Braas, Jason T. Lee, Art Catapang, K Ryan Trinh, Hanna M. Doh, Tianyuan Zhou, Shili Xu
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many coexpress HK1 and HK2. In contrast to HK1+HK2+ cancers, HK1−HK2+ cancer subsets are sensitive to cytostasis indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c808dbea3036f46e88ee0faf6e3ec0a
https://doi.org/10.1158/0008-5472.c.6510183
https://doi.org/10.1158/0008-5472.c.6510183
Autor:
Shili, Xu, Tianyuan, Zhou, Hanna M, Doh, K Ryan, Trinh, Art, Catapang, Jason T, Lee, Daniel, Braas, Nicholas A, Bayley, Reiko E, Yamada, Alex, Vasuthasawat, Joshua P, Sasine, John M, Timmerman, Sarah M, Larson, Youngsoo, Kim, A Robert, MacLeod, Sherie L, Morrison, Harvey R, Herschman
Publikováno v:
Cancer Res
Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many co-express HK1 and HK2. In contrast to HK1(+)HK2(+) cancers, HK1(−)HK2(+) cancer subsets are sensitive to cytost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecf1e4323701d38f9eff11fb3887814b
https://pubmed.ncbi.nlm.nih.gov/30885978
https://pubmed.ncbi.nlm.nih.gov/30885978