Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Nicholas A, Veldhuis"'
Autor:
Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 465-483 (2020)
Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment
Externí odkaz:
https://doaj.org/article/8f8f779f1b2f4f4d943c4c44b64c0667
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion channel expressed by various macrophage populations. Recent reports have characterized the role of TRPV4 in shaping the activity and phenotype of macrophages to
Externí odkaz:
https://doaj.org/article/9abfd3acf44443169e4fa151ace17e08
Autor:
Jeffri S. Retamal, Paulina D. Ramírez-García, Priyank A. Shenoy, Daniel P. Poole, Nicholas A. Veldhuis
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Peripheral and central neurons in the pain pathway are well equipped to detect and respond to extracellular stimuli such as pro-inflammatory mediators and neurotransmitters through the cell surface expression of receptors that can mediate rapid intra
Externí odkaz:
https://doaj.org/article/6c4549998de54b78bfc2d6ea2bed3f2a
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Publikováno v:
Journal of Materials Chemistry B.
In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments.
Autor:
Marc A. Dämgen, David M. Thal, Ron O. Dror, Arisbel B. Gondin, Julian A Harris, Yifan Cheng, Carl-Mikael Suomivuori, Nicholas A. Veldhuis, Bryan Faust, Aashish Manglik
Publikováno v:
Nature Chemical Biology. 18:109-115
The neuropeptide substance P (SP) is important in pain and inflammation. SP activates the neurokinin-1 receptor (NK1R) to signal via Gq and Gs proteins. Neurokinin A also activates NK1R, but leads to selective Gq signaling. How two stimuli yield dist
Autor:
Sadia Alvi, Daniel P. Poole, Peter McIntyre, Scott Peng, Arisbel B. Gondin, Paulina D. Ramírez-García, Pradeep Rajasekhar, Larissa K. Dill, Simona E. Carbone, Thomas P. Davis, Felix Bennetts, Jeffri S. Retamal, Megan S. Grace, Juhura G. Almazi, Nicholas A. Veldhuis, Nigel W. Bunnett
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) i
Autor:
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Alex R. B. Thomsen, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 119
G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and sign
Autor:
Arthur Christopoulos, Daniel P. Poole, Pradeep Rajasekhar, Celine Valant, Meritxell Canals, Vi Pham, Ayame Saito, Rhian Alice Ceredig, Nicholas A. Veldhuis, Dominique Massotte, Simona E. Carbone, Jesse J. DiCello
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 465-483 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, 9 (3), pp.465-483. ⟨10.1016/j.jcmgh.2019.11.006⟩
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, 9 (3), pp.465-483. ⟨10.1016/j.jcmgh.2019.11.006⟩
Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment
Autor:
Rocco, Latorre, Alan, Hegron, Chloe J, Peach, Shavonne, Teng, Raquel, Tonello, Jeffri S, Retamal, Rafael, Klein-Cloud, Diana, Bok, Dane D, Jensen, Lena, Gottesman-Katz, Jeanette, Rientjes, Nicholas A, Veldhuis, Daniel P, Poole, Brian L, Schmidt, Charalabos H, Pothoulakis, Carl, Rankin, Ying, Xie, Hon Wai, Koon, Nigel W, Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signal