Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Nicholas A, Stella"'
Autor:
Robert M. Q. Shanks, Sarah Atta, Nicholas A. Stella, Chollapadi V. Sundar-Raj, John E. Romanowski, Arman S. Grewal, Hazel Q. Shanks, Sonya M. Mumper, Deepinder K. Dhaliwal, Alex Mammen, Jake D. Callaghan, Rachel C. Calvario, Eric G. Romanowski, Regis P. Kowalski, Michael E. Zegans, Vishal Jhanji
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionPseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa isolates with lasR mut
Externí odkaz:
https://doaj.org/article/8ec495ac464e460e8c137979a0a63935
Autor:
Nathaniel S. Harshaw, Mitchell D. Meyer, Nicholas A. Stella, Kara M. Lehner, Regis P. Kowalski, Robert M. Q. Shanks
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT The Enterobacterial Rcs stress response system reacts to envelope stresses through a complex two-component phosphorelay system to regulate a variety of environmental response genes, such as capsular polysaccharide and flagella biosynthesis g
Externí odkaz:
https://doaj.org/article/3cecc05ef64f40a0af91b6ca977e23ea
Publikováno v:
BMC Ophthalmology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration. It is known that aut
Externí odkaz:
https://doaj.org/article/397e994854b34052a1982b97e387828f
Autor:
Nathaniel S. Harshaw, Nicholas A. Stella, Kara M. Lehner, Eric G. Romanowski, Regis P. Kowalski, Robert M. Q. Shanks
Publikováno v:
Antibiotics, Vol 10, Iss 9, p 1033 (2021)
The Rcs phosphorelay is a bacterial stress response system that responds to envelope stresses and in turn controls several virulence-associated pathways, including capsule, flagella, and toxin biosynthesis, of numerous bacterial species. The Rcs syst
Externí odkaz:
https://doaj.org/article/edfa77668cfc4d45911baaaeec365449
Autor:
Kimberly M Brothers, Jake D Callaghan, Nicholas A Stella, Julianna M Bachinsky, Mohammed AlHigaylan, Kara L Lehner, Jonathan M Franks, Kira L Lathrop, Elliot Collins, Deanna M Schmitt, Joseph Horzempa, Robert M Q Shanks
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007825 (2019)
Medical devices, such as contact lenses, bring bacteria in direct contact with human cells. Consequences of these host-pathogen interactions include the alteration of mammalian cell surface architecture and induction of cellular death that renders ti
Externí odkaz:
https://doaj.org/article/1729cb2794644a3098fcc774c40683f1
Autor:
Eric G. Romanowski, Nicholas A. Stella, Bryn L. Brazile, Kira L. Lathrop, Jonathan M. Franks, Ian A. Sigal, Tami Kim, Mennat Elsayed, Daniel E. Kadouri, Robert M.Q. Shanks
Publikováno v:
bioRxiv
PurposePseudomonas aeruginosakeratitis is a severe ocular infection that can lead to perforation of the cornea. In this study we evaluated the role of bacterial quorum sensing in generating corneal perforation and bacterial proliferation and tested w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e5ce963b2728532195ce7f384a3744
https://europepmc.org/articles/PMC10055036/
https://europepmc.org/articles/PMC10055036/
Autor:
Nicholas A. Stella, Eric G. Romanowski, Kimberly M. Brothers, Rachel C. Calvario, Robert M. Q. Shanks
Publikováno v:
Infect Immun
Bacterial stress response signaling systems, like the Rcs system are triggered by membrane and cell wall damaging compounds, including antibiotics and immune system factors. These regulatory systems help bacteria survive envelope stress by altering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1906d9f4403c13c1168e2c0c62430d32
https://europepmc.org/articles/PMC9671016/
https://europepmc.org/articles/PMC9671016/
Autor:
Kathleen A. Yates, Nicholas A. Stella, John E Romanowski, Deepinder K. Dhaliwal, Sanya Yadav, Robert M. Q. Shanks, Eric G. Romanowski
Publikováno v:
Curr Eye Res
PURPOSE: Females and males respond differently to a number of systemic viral infections. Differences between females and males with respect to the severity of keratitis caused by Gram-negative bacteria such as Serratia marcescens are less well establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3564881a4600b1a95e962f0ece7dcaf3
https://europepmc.org/articles/PMC9156527/
https://europepmc.org/articles/PMC9156527/
Autor:
Jes K. Klarlund, Regis P. Kowalski, Nancy A. McNamara, Robert M. Q. Shanks, Jake D. Callaghan, Nicholas A. Stella
Publikováno v:
J Ocul Pharmacol Ther
Purpose: The combined activity of the tear film and blinking is remarkably efficient at removal of foreign materials from the ocular surface. This has prevented the use of certain classes of drugs for the treatment of ocular surface problems. We prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb12db6ab6e3b107f60ff86c41b8fc09
https://doi.org/10.1089/jop.2019.0065
https://doi.org/10.1089/jop.2019.0065
Autor:
Kriya R. Patel, Nicholas A. Stella, Kara M. Lehner, Natalie C. Martin, Robert M. Q. Shanks, Jake D. Callaghan, Eric G. Romanowski
Publikováno v:
Polish Journal of Microbiology. 68:43-50
Several biotypes of the Gram-negative bacterium Serratia marcescens produce the tri-pyrole pigment and secondary metabolite prodigiosin. The biological activities of this pigment have therapeutic potential. For over half a century it has been known t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f255294e673eba4206b72b23ec9e7fd3
https://doi.org/10.21307/pjm-2019-005
https://doi.org/10.21307/pjm-2019-005