Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nicholas A, Honigschmidt"'
Autor:
Kumiko, Takeuchi, Todd J, Kohn, Nicholas A, Honigschmidt, Vincent P, Rocco, Patrick G, Spinazze, Daniel J, Koch, Steven T, Atkinson, Larry W, Hertel, David L, Nelson, D Bradley, Wainscott, Laura J, Ahmad, Janice, Shaw, Penny G, Threlkeld, David T, Wong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2393-2397
Potent 5-HT1A/SSRIs at low nanomolar and subnanomolar concentrations were identified in a series of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols. Incorporation of an alpha-Me group in the piperidine ring with its specific s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2415887eb761a5e60b2f6c86c07d36ec
https://doi.org/10.1016/s0960-894x(03)00392-5
https://doi.org/10.1016/s0960-894x(03)00392-5
Autor:
Kumiko Takeuchi, Todd J. Kohn, Nicholas A. Honigschmidt, Vincent P. Rocco, Patrick G. Spinazze, Susan K. Hemrick-Luecke, Linda K. Thompson, David C. Evans, Kurt Rasmussen, Deanna Koger, David Lodge, Laura J. Martin, Janice Shaw, Penny G. Threlkeld, David T. Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61281b6574f3b8c2cceccbc47e8fd960
https://pubmed.ncbi.nlm.nih.gov/16298130
https://pubmed.ncbi.nlm.nih.gov/16298130
Autor:
Vincent P. Rocco, Patrick G. Spinazze, Todd J. Kohn, Nicholas A. Honigschmidt, David L. Nelson, D. Bradley Wainscott, Laura J. Ahmad, Janice Shaw, Penny G. Threlkeld, David T. Wong, Kumiko Takeuchi
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(10)
A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f10f6b1df59c3ece005d1af7091cdaa
https://pubmed.ncbi.nlm.nih.gov/15109671
https://pubmed.ncbi.nlm.nih.gov/15109671
Autor:
Kumiko Takeuchi, Todd J Kohn, Nicholas A Honigschmidt, Vincent P Rocco, Patrick G Spinazze, Steven T Atkinson, Larry W Hertel, David L Nelson, D.Bradley Wainscott, Laura J Ahmad, Janice Shaw, Penny G Threlkeld, David T Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(22)
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1H-indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470085d4b8c94794f86762633f5876c1
https://pubmed.ncbi.nlm.nih.gov/14592479
https://pubmed.ncbi.nlm.nih.gov/14592479