Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Nicholas A, Bright"'
Autor:
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from
Externí odkaz:
https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f
Autor:
Elena V. Pavlova, Dorit Lev, Marina Michelson, Keren Yosovich, Hila Gur Michaeli, Nicholas A. Bright, Paul T. Manna, Veronica Kane Dickson, Karen L. Tylee, Heather J. Church, J. Paul Luzio, Timothy M. Cox
Publikováno v:
Human Mutation. 43:2265-2278
BackgroundA rare and fatal disease resembling mucopolysaccharidosis in infants, is caused by impaired intracellular endocytic trafficking due to deficiency of core components of the intracellular membrane-tethering protein complexes, HOPS and CORVET.
Autor:
Sophia Y. Breusegem, Jack Houghton, Raquel Romero-Bueno, Adrián Fragoso-Luna, Katherine A. Kentistou, Ken K. Ong, Anne F. J. Janssen, Nicholas A. Bright, Christian G. Riedel, John R. B. Perry, Peter Askjaer, Delphine Larrieu
Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report the first whole genome, multiparametric CRISPR anti-aging screen, identifying 43 new genes that can reverse multiple aging phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc91607169fdddf132b61efa64688b96
https://doi.org/10.2139/ssrn.4332061
https://doi.org/10.2139/ssrn.4332061
Autor:
J. Paul Luzio, Brett M. Collins, Nicholas A. Bright, Joel B. Dacks, James S. Swarbrick, Lena Wartosch, Harriet Crawley-Snowdon, Ji-Chun Yang, Luther J. Davis, Nathan R. Zaccai, Lauren P. Jackson, David J. Owen, Matthew N.J. Seaman, David Neuhaus, Emily K. Herman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Funder: Discovery Grants from the Natural Sciences and Engineering Research Council of Canada (RES0043758, RES0046091)
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-r
Autor:
Michael D.J. Parkinson, Luther J. Davis, Andrew A. Peden, J. Paul Luzio, Lena Wartosch, Nicholas A. Bright, Judith Mantell, James R. Edgar
Publikováno v:
Davis, L J, Bright, N A, Edgar, J R, Parkinson, M D J, Wartosch, L, Mantell, J M, Pedan, A A & Luzio, J P 2021, ' Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway ', Journal of Cell Science, vol. 134, no. 10, jcs255463 . https://doi.org/10.1242/jcs.255463
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science
article-version (VoR) Version of Record
To provide insights into the kiss-and-run and full fusion events resulting in endocytic delivery to lysosomes, we investigated conditions causing increased tethering and pore formation between late endocytic organelles in HeLa cells. Knockout of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a83b6f9f1fc8c7e1f1f0a750cf1e98
https://hdl.handle.net/1983/42c57471-e32d-4a11-a5b1-16a7d167d1cc
https://hdl.handle.net/1983/42c57471-e32d-4a11-a5b1-16a7d167d1cc
Autor:
Andrea Ballabio, Aleksey Shatunov, Lena E Nikolaeva, Elena Pavlova, J. Paul Luzio, Alena I Moskvina, Timothy M. Cox, Lena Wartosch, Karen Tylee, Nicholas A. Bright, Heather J. Church
Publikováno v:
Human Molecular Genetics
A rare lysosomal disease resembling a mucopolysaccharidosis with unusual systemic features, including renal disease and platelet dysfunction, caused by the defect in a conserved region of the VPS33A gene on human chromosome 12q24.31, occurs in Yakuts
Publikováno v:
Progress in molecular and subcellular biology. 57
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The c
Publikováno v:
Endocytosis and Signaling ISBN: 9783319967035
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b430d589331af0f82f12acf4b873e9
https://doi.org/10.1007/978-3-319-96704-2_6
https://doi.org/10.1007/978-3-319-96704-2_6
Autor:
Daniel J. Driscoll, Terry R. Willson, Subrayal M. Reddy, Roger P. Webb, Melanie J. Bailey, Nicholas J. Bright, Stephen M. Bleay, Neil I. Ward, Karen J. Kirkby
Publikováno v:
Forensic Science International. 230:81-86
The effect of vacuum exposure on latent fingerprint chemistry has been evaluated. Fingerprints were analysed using a quartz crystal microbalance to measure changes in mass, gas chromatography mass spectrometry to measure changes in lipid composition
Autor:
Brian N. Jones, Benjamin Jones, Ruth Croxton, Rosalind Wolstenholme, Simona Francese, Stephen Hinder, Sergei G. Kazarian, Roger P. Webb, Jesus J. Ojeda, Nicholas J. Bright, Leesa Susanne Ferguson, Sue Jickells, Stephen M. Bleay, Melanie J. Bailey
Publikováno v:
Analytical Chemistry. 84:8514-8523
The first analytical intercomparison of fingerprint residue using equivalent samples of latent fingerprint residue and characterized by a suite of relevant techniques is presented. This work has never been undertaken, presumably due to the perishable