Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Nicholas, Coleman"'
Autor:
Sara Benlhachemi, Redouane Abouqal, Nicholas Coleman, Matthew Jonathan Murray, Mohammed Khattab, Elmostafa El fahime
Publikováno v:
Non-coding RNA Research, Vol 8, Iss 3, Pp 413-425 (2023)
Background: Wilms tumour (WT) is caused by aberrant embryonic kidney development and associated with dysregulated expression of short, non-protein-coding RNAs termed microRNAs (miRNAs). At present, there is no reliable circulating biomarker of WT, an
Externí odkaz:
https://doaj.org/article/150ab7be41774d96b33902741428f2c7
Autor:
John T. Lafin, Cinzia G. Scarpini, Armon Amini, Bendu Konneh, Jeffrey M. Howard, Thomas Gerald, Michelle Nuno, Jin Piao, Anna Savelyeva, Zhaohui Wang, Jeffrey Gagan, Liwei Jia, Cheryl M. Lewis, Sarah Murray, Yun C. Sawa, Vitaly Margulis, Solomon L. Woldu, Douglas W. Strand, Nicholas Coleman, James F. Amatruda, A. Lindsay Frazier, Matthew J. Murray, Aditya Bagrodia
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Circulating miR-371a-3p has excellent performance in the detection of viable (non-teratoma) germ cell tumor (GCT) pre-orchiectomy; however, its ability to detect occult disease is understudied. To refine the serum miR-371a-3p assay in the mi
Externí odkaz:
https://doaj.org/article/8f30f5097b144b91a537ae6cb38b1d83
Autor:
Thomas R. W. Oliver, Lia Chappell, Rashesh Sanghvi, Lauren Deighton, Naser Ansari-Pour, Stefan C. Dentro, Matthew D. Young, Tim H. H. Coorens, Hyunchul Jung, Tim Butler, Matthew D. C. Neville, Daniel Leongamornlert, Mathijs A. Sanders, Yvette Hooks, Alex Cagan, Thomas J. Mitchell, Isidro Cortes-Ciriano, Anne Y. Warren, David C. Wedge, Rakesh Heer, Nicholas Coleman, Matthew J. Murray, Peter J. Campbell, Raheleh Rahbari, Sam Behjati
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal the
Externí odkaz:
https://doaj.org/article/a04dee3f9628403093fe2d0a118a0411
Autor:
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the li
Externí odkaz:
https://doaj.org/article/c14b563faf084d9f9abf9b953d1b62bf
Autor:
Paul McCrone, Hazel Everitt, Sabine Landau, Paul Little, Felicity L. Bishop, Gilly O’Reilly, Alice Sibelli, Rachel Holland, Stephanie Hughes, Sula Windgassen, Kim Goldsmith, Nicholas Coleman, Robert Logan, Trudie Chalder, Rona Moss-Morris
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Telephone therapist delivered CBT (TCBT) and web-based CBT (WCBT) have been shown to be significantly more clinically effective than treatment as usual (TAU) at reducing IBS symptom severity and impact at 12 months in adults with
Externí odkaz:
https://doaj.org/article/27aced6f4c414617999ca786ee29ac38
Autor:
Angela M. Araujo, Andrea Abaurrea, Peio Azcoaga, Joanna I. López-Velazco, Sara Manzano, Javier Rodriguez, Ricardo Rezola, Leire Egia-Mendikute, Fátima Valdés-Mora, Juana M. Flores, Liam Jenkins, Laura Pulido, Iñaki Osorio-Querejeta, Patricia Fernández-Nogueira, Nicola Ferrari, Cristina Viera, Natalia Martín-Martín, Alexandar Tzankov, Serenella Eppenberger-Castori, Isabel Alvarez-Lopez, Ander Urruticoechea, Paloma Bragado, Nicholas Coleman, Asís Palazón, Arkaitz Carracedo, David Gallego-Ortega, Fernando Calvo, Clare M. Isacke, María M. Caffarel, Charles H. Lawrie
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 19 (2022)
Externí odkaz:
https://doaj.org/article/3d06a870071548a9a083041ef64b61ed
Autor:
Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Del Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost, Karin Straathof, Sam Behjati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dediff
Externí odkaz:
https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
Autor:
John T. Lafin, Alexander P. Kenigsberg, Xiaosong Meng, Dreaux Abe, Anna Savelyeva, Nirmish Singla, Solomon L. Woldu, Yair Lotan, Ryan J. Mauck, Cheryl M. Lewis, Vitaly Margulis, Daniel Wong, Liwei Jia, Payal Kapur, Lin Xu, Ryan W. Speir, Gregory T. Chesnut, A. Lindsay Frazier, Douglas W. Strand, Nicholas Coleman, Matthew J. Murray, James F. Amatruda, Aditya Bagrodia
Publikováno v:
European Urology Open Science, Vol 26, Iss , Pp 83-87 (2021)
Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma ti
Externí odkaz:
https://doaj.org/article/1e906041cff244ba8e0c12744972018d
Autor:
Ian J Groves, Emma L A Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009875 (2021)
Development of cervical cancer is directly associated with integration of human papillomavirus (HPV) genomes into host chromosomes and subsequent modulation of HPV oncogene expression, which correlates with multi-layered epigenetic changes at the int
Externí odkaz:
https://doaj.org/article/c2ebaa15d87542a8b9191e3a5a74e587
Autor:
Matthew J. Murray, Stephen Smith, Dawn Ward, Lorena Verduci, James C. Nicholson, Cinzia G. Scarpini, Nicholas Coleman
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100904- (2021)
Germ-cell-tumours (GCTs) are heterogeneous and management is complex. The current conventional biomarkers, alpha-fetoprotein and human-chorionic-gonadotropin (HCG), have limited utility for diagnosis/follow-up as secretion is restricted to specific m
Externí odkaz:
https://doaj.org/article/c9fa24cf691747698283b390291289c1