C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

Autor: Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 584-597 (2020)

NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is availab

Externí odkaz: https://doaj.org/article/5d409e0254d546e4bebeb4a36d0593e8

Berberine Derivatives as Pseudomonas aeruginosa MexXY-OprM Inhibitors: Activity and In Silico Insights

Autor: Giorgia Giorgini, Gianmarco Mangiaterra, Nicholas Cedraro, Emiliano Laudadio, Giulia Sabbatini, Mattia Cantarini, Cristina Minnelli, Giovanna Mobbili, Emanuela Frangipani, Francesca Biavasco, Roberta Galeazzi

Publikováno v: Molecules, Vol 26, Iss 21, p 6644 (2021)

The natural alkaloid berberine has been demonstrated to inhibit the Pseudomonas aeruginosa multidrug efflux system MexXY-OprM, which is responsible for tobramycin extrusion by binding the inner membrane transporter MexY. To find a structure with impr

Externí odkaz: https://doaj.org/article/0260bdc7601d46bcb7d1ad71a4ced2cb

The Natural Alkaloid Berberine Can Reduce the Number of Pseudomonas aeruginosa Tolerant Cells

Autor: Barbara Citterio, Roberta Galeazzi, Emiliano Laudadio, Nicholas Cedraro, Francesca Andreoni, Gianmarco Mangiaterra, Francesca Biavasco, Cristina Minnelli, Giovanna Mobbili

Publikováno v: Journal of Natural Products. 84:993-1001

The eradication of recurrent Pseudomonas aeruginosa (PA) lung infection in cystic fibrosis (CF) patients may be hampered by the development of persistent bacterial forms, which can tolerate antibiotics through efflux pump overexpression. After demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5688452651eab34cec4429b55e7dcb19
https://doi.org/10.1021/acs.jnatprod.0c01151

Zooplankton as a Transitional Host for Escherichia coli in Freshwater

Autor: Andrea Di Cesare, Francesco Riva, Noemi Colinas, Giulia Borgomaneiro, Sara Borin, Pedro J. Cabello-Yeves, Claudia Canale, Nicholas Cedraro, Barbara Citterio, Elena Crotti, Gianmarco Mangiaterra, Francesca Mapelli, Vincenzo Mondino, Carla Vignaroli, Walter Quaranta, Gianluca Corno, Diego Fontaneto, Ester M. Eckert

Publikováno v: Applied and Environmental Microbiology. 88

This study shows that Escherichia coli can be temporarily enriched in zooplankton in natural conditions and that these bacteria can belong to different phylogroups and sequence types including environmental as well as clinical and animal isolates. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3ccee312120a7eaf6652f6b5cd1d2f
https://doi.org/10.1128/aem.02522-21

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

Autor: Maria Letizia Barreca, Stefano Sabatini, Gianmarco Mangiaterra, Andrea Astolfi, Francesca Biavasco, Violetta Cecchetti, Tommaso Felicetti, Oriana Tabarrini, Giuseppe Manfroni, Rolando Cannalire, Serena Massari, Donatella Pietrella, Nicholas Cedraro

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 584-597 (2020)

NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is availab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e49eec3bcb3aeef3c30cb29ee4f9e77
http://europepmc.org/articles/PMC7034129