Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Nicholas, Bertos"'
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Gertruda Evaristo, Amit Katz, José L. Ramírez-GarcíaLuna, Marianne S.M. Issac, Veena Sangwan, Duc-Vinh Thai, Nicholas Bertos, Marie-Christine Guiot, Sophie Camilleri-Broët, Victoria Marcus, Carmen Mueller, Jonathan Cools-Lartigue, Pierre O. Fiset, Lorenzo E. Ferri
Publikováno v:
Canadian Journal of Surgery. 66:E79-E87
Autor:
Salvador Flores-Torres, Tao Jiang, Jacqueline Kort-Mascort, Yun Yang, Omar Peza-Chavez, Sanjima Pal, Alisia Mainolfi, Lucas Antonio Pardo, Lorenzo Ferri, Nicholas Bertos, Veena Sangwan, Joseph M. Kinsella
Publikováno v:
ACS Biomaterials Science & Engineering. 9:542-561
Malignant tumor tissues exhibit inter- and intratumoral heterogeneities, aberrant development, dynamic stromal composition, diverse tissue phenotypes, and cell populations growing within localized mechanical stresses in hypoxic conditions. Experiment
Autor:
Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Catherine R. Dufour, Paul Savage, Nicholas Bertos, Radia M. Johnson, Tung Bui, Guillaume Bourque, Mark Basik, Vincent Giguère, Morag Park, William J. Muller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Histone modifications in cancer can contribute to pathogenesis. Here, the authors demonstrate that targeting epigenetic modifier Ezh2 hinders metastatic behaviour in Luminal B breast cancer models, and highlight a mechanism where Ezh2 contributes to
Externí odkaz:
https://doaj.org/article/08e7c695e7a0496dbcbb93d281626f1b
Soluble factors in malignant ascites promote the metastatic adhesion of gastric adenocarcinoma cells
Autor:
Luai Al-Marzouki, Vivian S. Stavrakos, Sanjima Pal, Betty Giannias, France Bourdeau, Roni Rayes, Nicholas Bertos, Sara Najmeh, Jonathan D. Spicer, Jonathan Cools-Lartigue, Swneke D. Bailey, Lorenzo Ferri, Veena Sangwan
Publikováno v:
Gastric Cancer. 26:55-68
Adenocarcinoma of the proximal stomach is the fastest rising malignancy in North America. It is commonly associated with peritoneal accumulation of malignant ascites (MA), a fluid containing cancer and inflammatory cells and soluble proteins. Periton
Autor:
Jose G. Teodoro, Morag Park, William Muller, Marie-Christine Guiot, Nahum Sonenberg, Michel L. Tremblay, Tina Gruosso, Bruno Gagnon, Trisha Rao, Isabelle Gamache, Owen J. Chen, Jieyi Yang, Harvey Smith, Ipshita Nandi, Wissal El-Assaad, Nicholas Bertos, Sung-Hoon Kim, Amro H. Mohammad
Figure S1. This figure compares ATP6AP2 expression in normal and tumour human prostate and breast tissues. Figure S2. This figure contains bright-field counterparts of LysoTracker images. This figure also contains HER2 immunostaining after PRR knockd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fefa12cb1790a53da8c9abda4294896
https://doi.org/10.1158/1541-7786.22515918
https://doi.org/10.1158/1541-7786.22515918
Autor:
Jose G. Teodoro, Morag Park, William Muller, Marie-Christine Guiot, Nahum Sonenberg, Michel L. Tremblay, Tina Gruosso, Bruno Gagnon, Trisha Rao, Isabelle Gamache, Owen J. Chen, Jieyi Yang, Harvey Smith, Ipshita Nandi, Wissal El-Assaad, Nicholas Bertos, Sung-Hoon Kim, Amro H. Mohammad
This figure contains clinical data that complement the observations made in Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e4035b49203341a9eb94c3694ec94
https://doi.org/10.1158/1541-7786.22515921.v1
https://doi.org/10.1158/1541-7786.22515921.v1
Autor:
Jose G. Teodoro, Morag Park, William Muller, Marie-Christine Guiot, Nahum Sonenberg, Michel L. Tremblay, Tina Gruosso, Bruno Gagnon, Trisha Rao, Isabelle Gamache, Owen J. Chen, Jieyi Yang, Harvey Smith, Ipshita Nandi, Wissal El-Assaad, Nicholas Bertos, Sung-Hoon Kim, Amro H. Mohammad
PTEN loss-of-function contributes to hyperactivation of the PI3K pathway and to drug resistance in breast cancer. Unchecked PI3K pathway signaling increases activation of the mechanistic target of rapamycin complex 1 (mTORC1), which promotes tumorige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3d7a1c6a2120a8c9ce068fb5795fc2b
https://doi.org/10.1158/1541-7786.c.6541218
https://doi.org/10.1158/1541-7786.c.6541218
Autor:
Jose G. Teodoro, Morag Park, William Muller, Marie-Christine Guiot, Nahum Sonenberg, Michel L. Tremblay, Tina Gruosso, Bruno Gagnon, Trisha Rao, Isabelle Gamache, Owen J. Chen, Jieyi Yang, Harvey Smith, Ipshita Nandi, Wissal El-Assaad, Nicholas Bertos, Sung-Hoon Kim, Amro H. Mohammad
Clinical parameters of patients from whom tissue microarrays were acquired for P-Akt staining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39dec0bc57c26071515692a4049c30aa
https://doi.org/10.1158/1541-7786.22515912
https://doi.org/10.1158/1541-7786.22515912
Autor:
Jose G. Teodoro, Morag Park, William Muller, Marie-Christine Guiot, Nahum Sonenberg, Michel L. Tremblay, Tina Gruosso, Bruno Gagnon, Trisha Rao, Isabelle Gamache, Owen J. Chen, Jieyi Yang, Harvey Smith, Ipshita Nandi, Wissal El-Assaad, Nicholas Bertos, Sung-Hoon Kim, Amro H. Mohammad
Sequence of qPCR, siRNA, and shRNA used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4a528b3501e402facc99159f4f96d9
https://doi.org/10.1158/1541-7786.22515906.v1
https://doi.org/10.1158/1541-7786.22515906.v1