Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees

Autor: Bernard Gagné, Nicholas Barden, Mario Harvey, Michel Labbé

Publikováno v: Psychiatric Genetics. 17:17-22

Objective Tryptophan hydroxylase is the rate-limiting enzyme in the serotonin biosynthetic pathway and plays an important role in the regulation of serotonin levels. Recently, a brain-specific isoform, tryptophan hydroxylase 2 or n-tryptophan hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57da8f69c06f047ae6fd18e262a59229
https://doi.org/10.1097/ypg.0b013e3280111877

Behavioral and Endocrine Impact of Impaired Type II Glucocorticoid Receptor Function in a Transgenic Mouse Modela

Autor: Isabelle Rousse, Alain Gratton, Joseph Rochford, Serge Beaulieu, Nicholas Barden

Publikováno v: Annals of the New York Academy of Sciences. 746:388-391

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a166472987b5baf94c0973cbc48055
https://doi.org/10.1111/j.1749-6632.1994.tb39263.x

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Autor: Daria Salyakina, Manfred Uhr, Elisabeth B. Binder, Marcus Ising, Bertram Müller-Myhsok, Roselind Lieb, Florian Holsboer, Nicholas Barden, Marcelo Paez-Pereda, Susanne Lucae, Michel Labbé, Mario Harvey, Inge Sillaber, Bernard Gagné, Tanja Brückl

Publikováno v: Human Molecular Genetics. 15:2438-2445

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic ATP-binding calcium channel expressed in neurons as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f60a8f7103fa8ac6ab20f7688c9893
https://doi.org/10.1093/hmg/ddl166

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder

Autor: J. Raymond DePaulo, Martin Alda, S H Juo, Philip B. Mitchell, Peter P. Zandi, Peter M. Visscher, Melvin G. McInnis, Johannes Schumacher, Michael Gill, Jenny Ekholm, Howard J. Edenberg, Stylianos E. Antonarakis, Nelson B. Freimer, Cathryn M. Lewis, Peter R. Schofield, Tatiana Foroud, Victor I. Reus, Jennifer A. Donald, Henrik Ewald, Takeo Yoshikawa, Conrad T. Gilliam, Rolf Adolfsson, Alison Goate, Theodore Reich, William Byerley, Elliot S. Gershon, Andrew McQuillin, Jouko Lönnqvist, Phil Bennett, Hugh Gurling, Paul Grof, Francis J. McMahon, Christine Windemuth, Judith A. Badner, L. J. Adams, John P. Rice, Wolfgang Maier, Michael Escamilla, Gursharan Kalsi, John I. Nurnberger, Douglas F. Levinson, Douglas Blackwood, Gustavo Turecki, Virginia L. Willour, Uppala Radhakrishna, Miron Baron, Hermann Luebbert, Jianjun Liu, Stuart MacGregor, Lynn R. Goldin, Eric Shink, Walter J. Muir, Pedro León, Torben A Kruse, Wade H. Berrettini, Nicholas John Craddock, Jurgen Del-Favero, John R. Kelsoe, Hilary Coon, Julien Mendlewicz, Sevilla D. Detera-Wadleigh, Jean-Louis Blouin, Leena Peltonen, Nurten A. Akarsu, Marcella Rietschel, Jean Morissette, Markus M. Nöthen, Christine Van Broeckhoven, M. Anne Spence, Peter Propping, Sven Cichon, Ole Mors, Nicholas Barden, Renee F. Badenhop, Stephan Claes, L. Alison McInnes, Ricardo Segurado, Guy A. Rouleau

Publikováno v: ResearcherID
American Journal of Human Genetics, Vol. 73, No 1 (2003) pp. 49-62

PUBLISHED
PMID: 12802785
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90680cf9fa645871cd26143366cb38a3

Support for the presence of bipolar disorder susceptibility loci on chromosome 5

Autor: Denis Rochette, Eric Shink, M. Plante, A Villeneuve, Carmen Laprise, Bernard Gagné, L. Bordeleau, Jean Morissette, Nicholas Barden

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 26:1273-1277

A very large pedigree derived from the Saguenay-Lac-St-Jean region of Quebec contains a branch where a distal chromosome 5q haplotype seems to cosegregate with bipolar affective disorder. The authors used a diagnosis model where Bipolar Types I and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2604721337a5f900c6bebe9b5f3ce200
https://doi.org/10.1016/s0278-5846(02)00266-x