Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Autor: Nicholas W. Wood, Chris C. A. Spencer, Konrad Koss, Heike I. Grabsch, Ananth C. Viswanathan, Simon C. Potter, Thomas L. Vaughan, Brian J. Reid, Céline Bellenguez, Kimberley Howarth, Claire Brooks, Michael Gibbons, Geoffrey Liu, David Ferry, Ian Tomlinson, Chuka U. Nwokolo, John de Caestecker, Barrie Rathbone, Francesco Lescai, Anna Rautanen, Weimin Ye, Nicholas I. Church, Nigel C. Bird, Laura J. Hardie, Peter H. Watson, Ross McManus, Peter Donnelly, David Cunningham, Peter Sasieni, Aiden Corvin, Cisca Wijmenga, Sarah Edkins, Amy Strange, Sheldon C. Cooper, Audrey Duncanson, Harvey A. Risch, Ian Sargeant, Christopher Macdonald, Pradeep Bhandari, Sarah E. Hunt, Matthew D. Rutter, John V. Reynolds, Nigel Trudgill, Rebecca Harrison, Anna H. Wu, Scott Sanders, Christopher G. Mathew, Mark S. Anderson, Raf Bisschops, Cathryn Edwards, Avazeh Tashakkori-Ghanbaria, Praful Patel, Wong Ho Chow, Anouk Van Der Winkel, Panos Deloukas, Kishor Vaidya, Manoj Nanji, Nichola L. Gellatly, Leena Peltonen, Iain A. Murray, Matthew A. Brown, Deborah Glancy, Marilie D. Gammon, Robert Plomin, Julie Hapeshi, Elia Stupka, Janusz Jankowski, Liam J. Murray, Alan G. Casson, Hugh McMurtry, Haythem Ali, Douglas A. Corley, Kausila Krishnadath, Hugh Barr, David Johnston, Derek Alderson, Ruth E Langley, Elvira Bramon, Saj Wajed, Sharon Love, Peter D. Siersema, Ernst J. Kuipers, Simon Panter, Mark R. Middleton, Ian D. Penman, Peter Isaacs, Krish Ragunath, David K. Levine, Paul Atherfold, Maikel P. Peppelenbosch, Joost P.H. Drenth, Claire Palles, Art Tucker, Stephen Attwood, Cordelia Langford, Rui Zhang, Matti Pirinen, Colin Freeman, Stephen Sawcer, Stuart MacGregor, Hugh S. Markus, S Paterson, Anna M. Nicholson, M Griffin, Nicola Burch, Colin Rodgers, Helen Winter, Anjan Dhar, Zhan Su, Emma Gray, Jantine W. P. M. van Baal, Richard C. Trembath, David Monk, Paul Mullins, Danielle Morris, Ashref Tawil, Serge Dronov, Hans Prenen, Yeng Ang, Dermot Kelleher, Gavin Band, Leslie Bernstein, Weronica E. Ek, H Smart, Luc J. W. van der Laan, Colin N. A. Palmer, Jenefer M. Blackwell, Wilbert H.M. Peters, David C. Whiteman, Tore Lind, Gosia Trynka, Helen Dallal, Paul Moayyedi, Russell D. Petty, Richard S. Gillies, Nicholas J. Shaheen, Chris Haigh, Sue Cullen, Gareth E. Davies, Julia Brown, Jean-Baptiste Cazier, Juan P. Casas, Yvonne Romero

Publikováno v: Nature Genetics, 44, 1131-6
Nature genetics
Nature Genetics, 44, 10, pp. 1131-6
Nature genetics, 44(10), 1131-+. Nature Publishing Group
Su, Z, Gay, L J, Strange, A, Palles, C, Band, G, Whiteman, D C, Lescai, F, Langford, C, Nanji, M, Edkins, S, van der Winkel, A, Levine, D, Sasieni, P, Bellenguez, C, Howarth, K, Freeman, C, Trudgill, N, Tucker, A T, Pirinen, M, Peppelenbosch, M P, van der Laan, L J W, Kuipers, E J, Drenth, J P H, Peters, W H, Reynolds, J V, Kelleher, D P, McManus, R, Grabsch, H, Prenen, H, Bisschops, R, Krishnadath, K, Siersema, P D, van Baal, J W P M, Middleton, M, Petty, R, Gillies, R, Burch, N, Bhandari, P, Paterson, S, Edwards, C, Penman, I, Vaidya, K, Ang, Y, Murray, I, Patel, P, Ye, W, Mullins, P, Wu, A H, Bird, N C, Lind, T & Esophageal Adenocarcinoma Genetics Consortium 2012, ' Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus ', Nature Genetics, vol. 44, no. 10, pp. 1131-6 . https://doi.org/10.1038/ng.2408
Nature Genetics, 44(10), 1131-+. Nature Publishing Group

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8117915f712f09f81ec147e0ad2843
http://ora.ox.ac.uk/objects/uuid:89f39572-3941-4dbb-b208-14af73dbc475

T1217 A Novel Population of CD56+ HLA-DR+ Colonic Lamina Propria Cells Is Associated with Inflammation in Ulcerative Colitis

Autor: Nicholas R. English, Nichola L. Gellatly, Andrew J. Stagg, Michael A. Kamm, Stella C. Knight, Siew C. Ng, Sophie Plamondon, Hafid O. Al-Hassi

Publikováno v: Gastroenterology. 134:A-509

INTRODUCTION: The immunopathology of ulcerative colitis (UC) relates to an inappropriate mucosal immune response to constituents of the intestinal microbiota in genetically susceptible individuals. HLA-DR+ lin-/dim (lin = anti-CD3,14,16,19,34) cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d117b10adf6869e984146339aa4dd71
https://doi.org/10.1016/s0016-5085(08)62374-4