Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Nichol E. Holodick"'
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107526- (2023)
Summary: The production and release of small phospholipid membrane vesicles, or extracellular vesicles (EVs), is a trait of most prokaryotic and eukaryotic cells. EVs display heterogeneity in content, size, biogenesis, activity, and function. B cells
Externí odkaz:
https://doaj.org/article/0d2bc1d3962a4d529f2b5b7edbaf261a
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionNatural antibody (NAb) derived from CD5+ B-1 cells maintains tissue homeostasis, controls inflammation, aids in establishing long-term protective responses against pathogens, and provides immediate protection from infection. CD5+ B-1 cell
Externí odkaz:
https://doaj.org/article/146f74f9a2dc4d50a61b8e248159c0e8
Autor:
Prasad Srikakulapu, Tanyaporn Pattarabanjird, Aditi Upadhye, Sai Vineela Bontha, Victoria Osinski, Melissa A. Marshall, James Garmey, Justine Deroissart, Thomas A. Prohaska, Joseph L. Witztum, Christoph J. Binder, Nichol E. Holodick, Thomas L. Rothstein, Coleen A. McNamara
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin M (IgM) to oxidation specific epitopes (OSE) are inversely associated with atherosclerosis in mice and humans. The B-1b subtype of B-1 cells secrete IgM to OSE, and unlike B-1a cells, are capable of long-lasting IgM memory. What attrib
Externí odkaz:
https://doaj.org/article/286501d5bfa64c20ac2f25408827ca76
Autor:
Monowar Aziz, Yasumasa Ode, Mian Zhou, Mahendar Ochani, Nichol E. Holodick, Thomas L. Rothstein, Ping Wang
Publikováno v:
Molecular Medicine, Vol 24, Iss 1, Pp 1-12 (2018)
Abstract Background Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and functionally unique sub-population of B cells, providing immediate p
Externí odkaz:
https://doaj.org/article/2d16342f825443bb97ea654ec6889b6f
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/a294905c42794c29bb0dcac16f6571bc
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The traditional definition of natural antibodies (NAbs) states that these antibodies are present prior to the body encountering cognate antigen, providing a first line of defense against infection thereby, allowing time for a specific antibody respon
Externí odkaz:
https://doaj.org/article/fbf62f0a84bb4f88ae41f35599785451
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the Aicda gene, plays a central role in class-switch recombination and somatic hypermutation in B cells. Although a role
Externí odkaz:
https://doaj.org/article/0ab3307d121340608f610d4b4196848f
Autor:
Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández
Publikováno v:
Journal of Immunology Research, Vol 2017 (2017)
P3 is a murine, germline, IgM mAb that recognizes N-glycolylated gangliosides and other self-antigens. This antibody is able to induce an anti-idiotypic IgG response and B-T idiotypic cascade, even in the absence of any adjuvant or carrier protein. P
Externí odkaz:
https://doaj.org/article/4bc5ddab6ff3485db5da05270d54eb98
Autor:
Joseph R. Tumang, Nichol E. Holodick, Teresa C. Vizconde, Hiroaki eKaku, Ruben eFrances, Thomas L Rothstein
Publikováno v:
Frontiers in Immunology, Vol 2 (2011)
B1 B cells defend against infectious microorganisms by spontaneous secretion of broadly reactive natural immunoglobulin that appears in the absence of immunization. Among many distinguishing characteristics, B1 B cells display evidence of activation
Externí odkaz:
https://doaj.org/article/603148fd441d4a4189b6d5541bba49d2
Publikováno v:
The Journal of Immunology. 208:1755-1771
Natural Abs are primarily produced by B-1 cells and are essential for protection against Streptococcus pneumoniae. The incidence and mortality rate for pneumococcal infection increases dramatically after age 65, disproportionately affecting males in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a319c9f8c60fab2225e0d657189e4ef8
https://doi.org/10.4049/jimmunol.2101150
https://doi.org/10.4049/jimmunol.2101150