Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nichelle Hairston"'
Autor:
Nichelle Hairston, Katherine Young, Artjohn Villafania, Milton L. Hammond, Nicholas Murgolo, Ronald E. Painter, Douglas Wisniewski, Mary Motyl, Daniel F. Sahm, Rumin Zhang, Carl J. Balibar, Fred Racine, Timothy A. Blizzard, Susan L. Raghoobar
Publikováno v:
BMC Microbiology
BMC Microbiology, Vol 19, Iss 1, Pp 1-14 (2019)
BMC Microbiology, Vol 19, Iss 1, Pp 1-14 (2019)
Background The prevalence of antibiotic resistance is increasing, and multidrug-resistant Pseudomonas aeruginosa has been identified as a serious threat to human health. The production of β-lactamase is a key mechanism contributing to imipenem resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa66d7281d6be8c3899743e477650e1e
https://doi.org/10.1186/s12866-019-1522-7
https://doi.org/10.1186/s12866-019-1522-7
Autor:
Timothy A. Blizzard, Nichelle Hairston, Jason E. Imbriglio, Young-Whan Park, Douglas Wisniewski, Paula M.D. Fitzgerald, Sookhee Ha, Nandini Sharma, Katherine Young, Jane Y. Wu, Giovanna Scapin, Aimie Ogawa, Susan L. Raghoobar, Jeff Hermes, Seongkon Kim, Ronald E. Painter, Rena Bodner, Jun Lu, Candido Gude, Helen Chen, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:780-785
β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C β-lactamase mediated antibiotic resistance. The pip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef95f2cd4732f80cdeca6fafc1d4dce
https://doi.org/10.1016/j.bmcl.2013.12.101
https://doi.org/10.1016/j.bmcl.2013.12.101
Autor:
Jane Y. Wu, Andrew S. Misura, Seongkon Kim, Ronald E. Painter, Nandini Sharma, Sookhee Ha, Amy Ogawa, Katherine Young, Jeff Hermes, Susan L. Raghoobar, Jun Lu, Sang Ho Lee, Young-Whan Park, T. Felcetto, Nichelle Hairston, Paula M.D. Fitzgerald, Timothy A. Blizzard, Helen Chen, Milton L. Hammond, Emily Hickey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:918-921
Bridged monobactam beta-lactamase inhibitors were prepared and evaluated as potential partners for combination with imipenem to overcome class C beta-lactamase mediated resistance. The (S)-azepine analog 2 was found to be effective in both in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321387328a1fea6b0d6c9d8da3fb3bce
https://doi.org/10.1016/j.bmcl.2009.12.069
https://doi.org/10.1016/j.bmcl.2009.12.069
Autor:
Edward DiNunzio, Fred Racine, Nicholas Murgolo, Lorraine D. Hernandez, Payal R. Sheth, Alex G. Therien, Li Xiao, Nichelle Hairston
Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrhea and primarily involve two exotoxins, TcdA and TcdB. Actoxumab and bezlotoxumab are human monoclonal antibodies that neutralize the cytotoxic/cytopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bebfd815a1e8a9a6e70b9c75b15551
https://europepmc.org/articles/PMC4335902/
https://europepmc.org/articles/PMC4335902/
Autor:
Douglas Wisniewski, Nichelle Hairston, Seongkon Kim, Timothy A. Blizzard, Aimie M. Ogawa, Jane Y. Wu, Young-Whan Park, Milton L. Hammond, Ronald E. Painter, Katherine Young, Jeff Hermes, Susan L. Raghoobar, Giovanna Scapin, Nandini Sharma, Helen Chen, Paula M.D. Fitzgerald, Jun Lu
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(14)
The bridged monobactam β-lactamase inhibitor MK-8712 (1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C β-lactamase media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0c4138f7c39ede92a29f86721a221d
https://pubmed.ncbi.nlm.nih.gov/21676616
https://pubmed.ncbi.nlm.nih.gov/21676616
Autor:
M A Powles, David B. Olsen, Katherine Young, Li Xiao, Nicholas Murgolo, Karen Dorso, Edward DiNunzio, Fred Racine, Gregory C. Adam, Douglas Wisniewski, Michael A. Goetz, Nichelle Hairston, Marta Arocho, Jing Su, Olga Genilloud, Ronald E. Painter, Robert G. K. Donald, Charles Gill, Bakela Nare, Francisca Vicente, Milton L. Hammond
Publikováno v:
Chemistry & Biology. (10):1362-1373
SummaryResistance to existing classes of antibiotics drives the need for discovery of novel compounds with unique mechanisms of action. Nargenicin A1, a natural product with limited antibacterial spectrum, was rediscovered in a whole-cell antisense a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523a3a9b2e7bed31dc33d30f1ca55803