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Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors.

Autor: Johnston AC; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Alicea GM; Institute for NanoBioTechnology, Johns Hopkins University., Lee CC; Department of Biomedical Engineering, Johns Hopkins University., Patel PV; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Hanna EA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Vaz E; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Forjaz A; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Wan Z; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University., Nair PR; Institute for NanoBioTechnology, Johns Hopkins University., Lim Y; Department of Biomedical Engineering, Johns Hopkins University., Chen T; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Du W; Department of Chemical & Biomolecular Engineering, Johns Hopkins University., Kim D; Department of Biomedical Engineering, Yale University., Nichakawade TD; Department of Chemical & Biomolecular Engineering, Johns Hopkins University.; Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins University., Rebecca VW; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University., Bonifant CL; Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins University., Fan R; Department of Biomedical Engineering, Yale University., Kiemen AL; Institute for NanoBioTechnology, Johns Hopkins University.; Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University.; Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins University., Wu PH; Department of Chemical & Biomolecular Engineering, Johns Hopkins University.; Institute for NanoBioTechnology, Johns Hopkins University., Wirtz D; Department of Chemical & Biomolecular Engineering, Johns Hopkins University.; Institute for NanoBioTechnology, Johns Hopkins University.; Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University.; Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins University.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 26. Date of Electronic Publication: 2024 Mar 26.