Výsledky vyhledávání - "Nicely, P. A."

Akademický článek

Opinion: Beyond global means – novel space-based approaches to indirectly constrain the concentrations of and trends and variations in the tropospheric hydroxyl radical (OH)

Autor: B. N. Duncan, D. C. Anderson, A. M. Fiore, J. Joiner, N. A. Krotkov, C. Li, D. B. Millet, J. M. Nicely, L. D. Oman, J. M. St. Clair, J. D. Shutter, A. H. Souri, S. A. Strode, B. Weir, G. M. Wolfe, H. M. Worden, Q. Zhu

Publikováno v: Atmospheric Chemistry and Physics, Vol 24, Pp 13001-13023 (2024)

The hydroxyl radical (OH) plays a central role in tropospheric chemistry, as well as influencing the lifetimes of some greenhouse gases. Because of limitations in our ability to observe OH, we have historically relied on indirect methods to constrain

Externí odkaz: https://doaj.org/article/c767d6d5559547558a930b70e7ed7c49

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Akademický článek

Trends and Interannual Variability of the Hydroxyl Radical in the Remote Tropics During Boreal Autumn Inferred From Satellite Proxy Data

Autor: Daniel C. Anderson, Bryan N. Duncan, Junhua Liu, Julie M. Nicely, Sarah A. Strode, Melanie B. Follette‐Cook, Amir H. Souri, Jerry R. Ziemke, Gonzalo González‐Abad, Zolal Ayazpour

Publikováno v: Geophysical Research Letters, Vol 51, Iss 8, Pp n/a-n/a (2024)

Abstract Despite its importance for the global oxidative capacity, spatially resolved trends and variability of the hydroxyl radical (OH) are poorly constrained. We demonstrate the utility of a tropospheric column OH (TCOH) product, created from mach

Externí odkaz: https://doaj.org/article/046f1030cdf6420eba0de81213908a34

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Akademický článek

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

Autor: Xavier Bonner, Amy Sondgeroth, Amelia McCue, Nathan Nicely, Ashutosh Tripathy, Ean Spielvogel, Matthew Moeser, Ruian Ke, Karin Leiderman, Sarah B. Joseph, Ronald Swanstrom

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTHuman immunodeficiency virus type 1 typically requires a high density of CD4 for efficient entry as a mechanism to target CD4+ T cells (T-tropic), with CCR5 being used most often as the coreceptor. When target T cells are limiting, the virus

Externí odkaz: https://doaj.org/article/02047abda3bb4f598e57b531a3a08f9d

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Akademický článek

Development and optimisation of in vitro sonodynamic therapy for glioblastoma

Autor: Andrew Keenlyside, Theodore Marples, Zifan Gao, Hong Hu, Lynden Guy Nicely, Joaquina Nogales, Han Li, Lisa Landgraf, Anna Solth, Andreas Melzer, Kismet Hossain-Ibrahim, Zhihong Huang, Sourav Banerjee, James Joseph

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Sonodynamic therapy (SDT) is currently on critical path for glioblastoma therapeutics. SDT is a non-invasive approach utilising focused ultrasound to activate photosensitisers like 5-ALA to impede tumour growth. Unfortunately, the molecular

Externí odkaz: https://doaj.org/article/ecd35743cba54280bef0d41c1a280ad8

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Akademický článek

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Akademický článek

Technical note: Constraining the hydroxyl (OH) radical in the tropics with satellite observations of its drivers – first steps toward assessing the feasibility of a global observation strategy

Autor: D. C. Anderson, B. N. Duncan, J. M. Nicely, J. Liu, S. A. Strode, M. B. Follette-Cook

Publikováno v: Atmospheric Chemistry and Physics, Vol 23, Pp 6319-6338 (2023)

Despite its importance in controlling the abundance of methane (CH4) and a myriad of other tropospheric species, the hydroxyl radical (OH) is poorly constrained due to its large spatial heterogeneity and the inability to measure tropospheric OH with

Externí odkaz: https://doaj.org/article/28c3d1cf29094be693723bd78feaa01e

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Akademický článek

Synthesis of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and in vitro anti-glioma activity

Autor: Ruturajsinh M. Vala, Vasudha Tandon, Lynden G. Nicely, Luxia Guo, Yanlong Gu, Sourav Banerjee, Hitendra M. Patel

Publikováno v: Annals of Medicine, Vol 54, Iss 1, Pp 2549-2561 (2022)

A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres. A collect

Externí odkaz: https://doaj.org/article/50ae6339b0b74d54bcfdd2363b0342d3

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